Search results for "Zen"

Efficacy and safety of ezetimibe added to atorvastatin versus atorvastatin uptitration or switching to rosuvastatin in patients with primary hypercho…

2013

Hypercholesterolemic patients (n = 1,547) at high atherosclerotic cardiovascular disease risk with low-density lipoprotein cholesterol (LDL-C) levels ≥100 and ≤160 mg/dl while treated with atorvastatin 10 mg/day entered a multicenter, randomized, double-blind, active-controlled, clinical trial using two 6-week study periods. Period I compared the efficacy/safety of (1) adding ezetimibe 10 mg (ezetimibe) to stable atorvastatin 10 mg, (2) doubling atorvastatin to 20 mg, or (3) switching to rosuvastatin 10 mg. Subjects in the latter 2 groups who persisted with elevated LDL-C levels (≥100 and ≤160 mg/dl) after period I, entered period II; subjects on atorvastatin 20 mg had ezetimibe added to th…

Targeted use of intraoperative frozen-section analysis lowers the frequency of completion thyroidectomy

2021

Abstract Background The impact of intraoperative frozen section (iFS) analysis on the frequency of completion thyroidectomy for the management of thyroid carcinoma is controversial. Although specialized endocrine centres have published their respective results, there are insufficient data from primary and secondary healthcare levels. The aim of this study was to analyse the utility of iFS analysis. Methods In the Prospective Evaluation Study Thyroid Surgery (PETS) 2 study, 22 011 operations for benign and malignant thyroid disease were registered prospectively in 68 European hospitals from 1 July 2010 to 31 December 2012. Group 1 consisted of 569 patients from University Medical Centre (UMC…

Three-year (2017-2019) activity report of the Replantation Service for hand amputations in Poland

2021

W pracy przedstawiono podsumowanie działalności Serwisu Replantacyjnego dla amputacji rąk w Polsce w latach 2017-2019. W analizowanym okresie, do Serwisu zgłoszono 551 przypadków amputacji i innych rozległych urazów kończyn górnych, z czego 330 zaakceptowano do operacji, a w 221 przypadkach, z różnych powodów odmówiono przyjęcia. Wśród 330 przyjętych było 165 (50%) amputacji całkowitych, 131 (40%) prawie całkowitych i 34 (10%) inne, ciężkie, zagrażające utratą kończyny urazy. W przeważającej liczbie ofiarami byli mężczyźni w młodym i średnim wieku. Najwięcej było amputacji kilku palców i kciuków - 251 (76%), następnie amputacji na poziomie śródręcza - 30 (9%), przedramienia - 23 (7%) i nadg…

Protection against 2,4,6-trinitrobenzenesulphonic acid-induced colonic inflammation in mice by the marine products bolinaquinone and petrosaspongioli…

2005

Proinflammatory mediators, namely eicosanoids, reactive oxygen and nitrogen species and cytokines, are clearly involved in the pathogenesis of intestinal bowel disease. bolinaquinone (BQ) and petrosaspongiolide M (PT), two marine products with potent anti-inflammatory action, have been shown to control the production of mediators in acute and chronic inflammatory processes. Hence, we have tested here the hypothesis that BQ and PT could ameliorate inflammation and oxidative stress parameters in 2,4,6-trinitrobenzenesulphonic acid (TNBS)-induced colitis in Balb/c mice. BQ and PT were given orally in doses of 10 or 20mg/kg/day. Treatment of the animals with BQ or PT at the highest dose signifi…

Prognostic Impact of Frozen Section Investigation and Extent of Proximal Safety Margin in Gastric Cancer Resection

2020

Background and aims Guidelines propose different extents of macroscopic proximal margin for gastric cancer and frozen margin investigation in selected cases, but data is lacking. This study was to evaluate the necessary extent of macroscopic proximal margin, accuracy of frozen margin investigation, and prognostic impact of tumor-free proximal margin length in pT2-pT4 gastric cancer. Study design Proximal and distal frozen margins were routinely investigated intraoperatively in all pT2-pT4 gastric cancers resected between 2011 and 2017. Macroscopic and microscopic proximal margin lengths were correlated. For R0-resections, survival analysis was performed for distal gastrectomy (DG) with micr…

CITIZEN SCIENCE: A SUCCESSFUL TOOL FOR MONITORING MARINE BIODIVERSITY

2019

The Mediterranean Sea, considered as a true hotspot of biodiversity, is currently experiencing a decline in the number of species and a deterioration of habitats, as a consequence of different anthropogenic pressures, which are predicted to increase in the future. Among these pressures, the increase of human population, habitat modification and loss, pollution, coastal urbanization, overexploitation, the intentional or indirect introduction of Non-Indigenous Species (NIS, i.e. organisms introduced outside of their natural range) and climate changes (i.e. acidification and warming) have been pointed out as the major threats to biodiversity. Therefore, biodiversity monitoring and surveillance…

New Challenges of Economic and Business Development – 2012 : Conference Proceedings (May 10 - 12, 2012, Riga, University of Latvia)

2012

Support for Conference Proceedings by ERAF Project "Support for the international cooperation projects and other international cooperation activities in research and technology at the University of Latvia" No. 2010/0202/2DP/2.1.1.2.0/10/APIA/VIAA/013

Can goal setting and performance feedback enhance organizational citizenship behavior?

2008

Political Skills in Organizations: Do Personality and Reputation Play a Role?

2008

between altruistic behavior (goodwill toward co workers) and compliance behavior (attitude to ward the firm and its regulations, mission, etc.). It turned out that job satisfaction was related to formal performance and compliance behavior, but not to altruistic behavior. Job commitment was also related to formal performance. Finally, goal setting was related to formal performance and altruistic behavior but was not connected to com pliance behavior. In the second stage of the study, supervisors who had participated in earlier evaluations reas sessed employees' performance and feedback. The feedback included information about formal goal attainment as well as informal behaviors such as suppo…

Internal employability as a strategy for key employee retention

2014

Las economías alrededor del mundo, en especial en países delsur de Europa, están sufriendo los paralizantes efectos de la extremadamentecompleja crisis económica y financiera. Este estudio examina el impactode ciertas políticas de recursos humanos enfocadas a incrementarla empleabilidad interna como un medio para retener a los empleados valiososy para promover la flexibilidad laboral dentro de la empresa, asícomo para incrementar las actitudes positivas hacia la ciudadanía organizacional.Se proponen la satisfacción y el compromiso como variables queintermedian la relación entre la empleabilidad interna percibida y la intenciónde abandonar la empresa y sobre el desarrollo de comportamientode…