Search results for "aRR"
showing 10 items of 10185 documents
Buccal drug delivery: what's new and what does the future hold?
2014
The buccal mucosa is the stratified squamous epithelial tissue inside lining of the cheeks. It is a favorable site of drug absorption since the tissue is non-keratinized, relatively immobile and strongly supplied with blood by a dense capillary-vessel network; moreover, it is highly tolerant to allergens, resistant to potentially harmful agents and has a relatively low enzymatic activity. The tissue consents quick onset of effect, offers an easily accessible and generally well-accepted site for drug delivery, is a useful route of administration in patients in an unconscious state (e.g., when swallowing is impaired), and is suitable for retentive dosage forms of administration. Buccal mucosa…
COMBINATION OF ARGAN OIL AND PHOSPHOLIPIDS FOR THE DEVELOPMENT OF AN EFFECTIVE LIPOSOME-LIKE FORMULATION ABLE TO IMPROVE SKIN HYDRATION AND ALLANTOIN…
2016
Allantoin is traditionally employed in the treatment of skin ulcers and hypertrophic scars. In the present work, to improve its local deposition in the skin and deeper tissues, allantoin was incorporated in conventional liposomes and in new argan oil enriched liposomes. In both cases, obtained vesicles were unilamellar, as confirmed by cryo-TEM observation, but the addition of argan oil allowed a slight increase of the mean diameter (∼130nm versus ∼85nm). The formulations, especially those containing argan oil, favoured the allantoin accumulation in the skin, in particular in the dermis (∼8.7μg/cm(2)), and its permeation through the skin (∼33μg/cm(2)). The performances of vesicles as skin d…
Gold nanostar–polymer hybrids for siRNA delivery: Polymer design towards colloidal stability and in vitro studies on breast cancer cells
2017
To overcome the low bioavailability of siRNA (small interfering RNA) and to improve their transfection efficiency, the use of non-viral delivery carriers is today a feasible approach to transform the discovery of these incredibly potent and versatile drugs into clinical practice. Polymer-modified gold nanoconstructs (AuNCs) are currently viewed as efficient and safe intracellular delivery carriers for siRNA, as they have the possibility to conjugate the ability to stably entrap and deliver siRNAs inside cells with the advantages of gold nanoparticles, which can act as theranostic agents and radiotherapy enhancers through laser-induced hyperthermia. In this study, AuNCs were prepared by coat…
Educatio siglo XXI : revista de la Facultad de Educación
2015
La presencialidad obligatoria en Educación Superior y el creciente número de estudiantes con compromisos familiares justifican la necesidad de conocer las opiniones del alumnado con respecto a la conciliación estudiantil-familiar en el contexto universitario. Se adopta una metodología cualitativa mediante narrativas. Participan de la investigación 27 estudiantes de la Universitat de València y 46 de la Universidad de Alicante, del Grado en Maestro de Educación Primaria. Los resultados evidencian limitaciones, dificultades y demandas ante las nuevas exigencias metodológicas y evaluativas, si se tienen cargas familiares. Se concluye con propuestas académicas, legislativas y de implementación …
The New "Maximum Yield Grid" (MYG) Array in Full 3D Resistivity Tomography
2008
Over the past few years geoelectrical prospecting has experienced many innovations, ranging from instrumental refinements to improvement of data interpretation. The consequence of this has been a strong increase in the method s resolution power and, therefore, its field of application has broadened. Nevertheless, the diffusion of 3D surveys in electrical resistivity tomography has been very much limited by the long acquisition time required by this kind of investigation, as compared to 2D ERT or other geophysical exploration methods like GPR. However, 3D ERT has a great advantage in terms of resolution power, that is very important in many applications, such as archeological or cultural her…
Integrated CGH/WES Analyses Advance Understanding of Aggressive Neuroblastoma Evolution: A Case Study
2021
Neuroblastoma (NB) is the most common extra-cranial malignancy in preschool children. To portray the genetic landscape of an overly aggressive NB leading to a rapid clinical progression of the disease, tumor DNA collected pre- and post-treatment has been analyzed. Array comparative genomic hybridization (aCGH), whole-exome sequencing (WES), and pharmacogenetics approaches, respectively, have identified relevant copy number alterations (CNAs), single nucleotide variants (SNVs), and polymorphisms (SNPs) that were then combined into an integrated analysis. Spontaneously formed 3D tumoroids obtained from the recurrent mass have also been characterized. The results prove the power of combining C…
A Geometrical Three-Ring-Based Model for MIMO Mobile-to-Mobile Fading Channels in Cooperative Networks
2011
Published version of an article published in the journal: Eurasip Journal on Advances in Signal Processing. Also available from the publisher at: http://dx.doi.org/10.1155/2011/892871. OA This paper deals with the modeling and analysis of narrowband multiple-input multiple-output (MIMO) mobile-to-mobile (M2M) fading channels in relay-based cooperative networks. In the transmission links from the source mobile station to the destination mobile station via the mobile relay, non-line-of-sight (NLOS) propagation conditions are taken into account. A stochastic narrowband MIMO M2M reference channel model is derived from the geometrical three-ring scattering model, where it is assumed that an infi…
Managing archaeological excavations with an Archeaological Information System (SIDGEIPA)
2003
Se analizan diferentes aspectos del proceso que hemos seguido para desarrollar e implementar un software completamente nuevo para gestionar excavaciones arqueológicas. El software llamado SIDGEIPA (Sistema Distribuido para la Gestión Integrada de excavaciones arqueológicas) incluye diferentes módulos que permiten a los usuarios almacenar datos arqueológicos de diferentes fuentes (excavaciones, prospecciones, literatura científica, colecciones de museos ...) y procesarlos automáticamente para simplificar la investigación arqueológica. Técnicamente, Sidgeipa está construido en código Java, utilizando Postgres como SGBD y con las bibliotecas VTK y GEF para visualizar los datos. La arquitectura…
Polyphony in the classroom: reporting narrative action research reflexively
2010
In this article we will present a reflexive way of producing a narrative analysis on teaching and learning that involves all participants of the pedagogical process. Our theoretical contribution rests on the concept ‘lived pedagogy’, adapted from Max van Manen's term ‘lived experience’. Like van Manen, we start by asking the key question of phenomenological–hermeneutical research: what is the nature of the phenomenon as meaningfully experienced? For us, the phenomenon is the pedagogical relationship; the interaction between the people involved in the pedagogical process. Thus, we will present how lived pedagogy is researched through the narratives told by the teacher‐researcher, the student…
"Table 2" of "Charm-quark fragmentation fractions and production cross section at midrapidity in pp collisions at the LHC"
2022
Fragmentation fractions of charm quark to open-charm hadrons $f(\mathrm{c \rightarrow H_c})$ in pp collisions at $\sqrt{s} = 5.02$ TeV.