Search results for "accumulation"
showing 10 items of 240 documents
Risk of chemotherapy-associated liver injury (CALI) in PNPLA3 p.148M allele carriers: Preliminary results of a transient elastography-based study
2019
Liver steatosis is one of the side effects of chemotherapy. The PNPLA3 p.I148M, TM6SF2 p.E167K and MBOAT7 p.G17E variants represent genetic determinants for progressive liver diseases. Here, we investigate their association with chemotherapy-associated steatosis.Prospectively, we recruited 87 patients undergoing systemic chemotherapy for gastrointestinal cancers. Hepatic fat (controlled attenuation parameter, CAP) and liver stiffness (LSM) were measured non-invasively before the initiation of chemotherapy (T0) and after at least two (T1) and four cycles (T2). Genetic variants were genotyped using allelic discrimination assays.In the final dataset (n = 60) patients demonstrated the following…
Is metal accumulation in Pomphorhynchus laevis dependent on parasite sex or infrapopulation size?
2010
SUMMARYConcentrations of the elements As, Cd, Co, Cu, Fe, Mn, Mo, Ni, Pb, Sn, V, Zn were analysed by inductively coupled plasma mass spectrometry (ICP-MS) in the acanthocephalan Pomphorhynchus laevis and its fish host Barbus barbus. A total of 27 barbels were collected from the Danube River in autumn 2006 close to the town Kozloduy (685 river kilometer) on the Bulgarian river bank. Fish were divided into 3 groups. According to their P. laevis infrapopulation size hosts were considered as heavily infected (>100 worms per fish) and lightly infected (<20 worms per fish). The third group was used to compare heavy metal concentrations between male and female P. laevis. The 5 elements As, C…
The control of the residual lifetimes of carbon fibre-reinforced composite pressure vessels
2015
International audience; The understanding of the degradation of carbon fibre composites, with emphasis on the use of these composites in filament-wound pressure vessels, is explored. Earlier studies by many researchers have led to a general appreciation of the mechanisms involved; however, only recently have both computational power and experimental techniques become sufficiently developed to allow for the use of quantitative analyses. It is shown that damage is controlled by fibre failure, and that initially this occurs randomly within the structure. In monotonic loading, the development of clusters of fibre breaks causes rapid failure; however, under maintained loads the kinetics of damag…
Sample building orientation effect on porosity and mechanical properties in Selective Laser Melting of Ti6Al4V titanium alloy
2022
Abstract In recent decades, the focus of research has shifted towards new production technologies with the aim of optimizing production and reducing costs. These innovative technologies include additive manufacturing processes as Selective Laser Melting (SLM). The analysis of the literature on the identification of optimal building orientation to maximize the mechanical properties and minimize porosity of the final products highlights contrasting results, denoting that the thermomechanical complexity of the process, as associated with the variation of the building orientation, has not been fully clarified. A study in which the building orientation effect was evaluated together with the geom…
Investigation on fracture of epoxy-filled composites by acoustic emission
2016
Acoustic emission (AE) technique is widely used to monitor failure processes in composite materials includ-ing development of cracks and plastic deformations within the polymer matrix, fracture and debonding of inclusions, etc. In this study, the AE technique was applied investigating failure character of epoxy polymers with different content of nanofiller – fine polyethersulfone (PES) powder. Variation of material properties of the epoxy with 0, 5%, 7.5%, 10%, and 12.5% concentration (by weight) of the PES was assessed experimentally. Correlation between the PES content and the modulus of elasticity was found negligible. The same was characteristic for the tensile strength. Whereas, such a…
Targeted tumor imaging of anti-CD20-polymeric nanoparticles developed for the diagnosis of B-cell malignancies
2015
Sara Capolla,1 Chiara Garrovo,2 Sonia Zorzet,1 Andrea Lorenzon,3 Enrico Rampazzo,4 Ruben Spretz,5 Gabriele Pozzato,6 Luis N&uacute;&ntilde;ez,7 Claudio Tripodo,8 Paolo Macor,1,9 Stefania Biffi2 1Department of Life Sciences, University of Trieste, 2Institute for Maternal and Child Health &ndash; IRCCS &ldquo;Burlo Garofolo&rdquo;, Trieste, 3Animal Care Unit, Cluster in Biomedicine (CBM scrl), Trieste, Italy; 4Department of Chemistry &ldquo;G. Ciamician&rdquo;, University of Bologna, Bologna, Italy; 5LNK Chemsolutions LLC, Lincoln, NE, USA; 6Department of Medical, Surgery and Health Sciences, University of Trieste, Trieste, Italy; 7Bio-Target, Inc., University of C…
The Mediterranean diet and its individual components: Linking with obesity in Italy
2020
Abstract A prolonged positive energy balance may contribute to fat accumulation and obesity development. It was observed several years ago that population resident in southern Italy consumed a particular diet and was less obese and lived significantly longer, and it was referred as the Mediterranean diet. The Mediterranean diet is a dietary plan based on fruits, vegetables, olive oil, and low intake of saturated fatty acids. A large body of literature suggested that the Mediterranean diet is effective in preventing obesity. Both observational and intervention studies clearly demonstrated that a higher adherence to Mediterranean diet is associated with a reduced risk of being obese and that …
The biogeochemical cycle of mercury in the Augusta Bay
2014
Mercurial, the metaphor for volatile unpredictable behavior, aptly reflects the complexities of one of the most insidiously interesting and scientifically challenging biogeochemical cycles at the Earth’s surface. At the base of this toxic metal cycle there is the conversion between the different Hg chemical species, in which the balance between the reduced and oxidized forms depends primary on redox system conditions. The potential risks of human exposure to Hg, especially in the form of monomethylmercury (MMHg), particularly prenatally, and the potential deleterious ecological consequences from localized to global scale Hg pollution, have given much impetus to mercury studies and regulator…
Uncontrolled methane emissions from a MSW landfill surface: Influence of landfill features and side slopes
2013
Sanitary landfills for Municipal Solid Waste (MSW) disposal have been identified as one of the most important anthropogenic sources of methane (CH4) emissions; in order to minimize its negative effects on the environment, landfill gas (LFG) recovery is a suitable tool to control CH4 emissions from a landfill site; further, the measurement of CH4 emissions can represent a good way to evaluate the effectiveness of LFG recovering systems. In general, LFG will escape through any faults in the landfill capping or in the LFG collection system. Indeed, some areas of the capping can be more permeable than others (e.g. portions of a side slope), especially when considering a temporarily capped zone …
Evaluation of methane emissions from Palermo municipal landfill: Comparison between field measurements and models
2010
Methane (CH(4)) diffuse emissions from Municipal Solid Waste (MSW) landfills represent one of the most important anthropogenic sources of greenhouse gas. CH(4) is produced by anaerobic biodegradation of organic matter in landfilled MSW and constitutes a major component of landfill gas (LFG). Gas recovery is a suitable method to effectively control CH(4) emissions from landfill sites and the quantification of CH(4) emissions represents a good tool to evaluate the effectiveness of a gas recovery system in reducing LFG emissions. In particular, LFG emissions can indirectly be evaluated from mass balance equations between LFG production, recovery and oxidation in the landfill, as well as by a d…