Search results for "acting"
showing 10 items of 338 documents
Deformation and mixing of coexisting shapes in neutron-deficient polonium isotopes
2015
Coulomb-excitation experiments are performed with postaccelerated beams of neutron-deficient Po196,198,200,202 isotopes at the REX-ISOLDE facility. A set of matrix elements, coupling the low-lying states in these isotopes, is extracted. In the two heaviest isotopes, Po200,202, the transitional and diagonal matrix elements of the 2+1 state are determined. In Po196,198 multistep Coulomb excitation is observed, populating the 4+1,0+2, and 2+2 states. The experimental results are compared to the results from the measurement of mean-square charge radii in polonium isotopes, confirming the onset of deformation from Po196 onwards. Three model descriptions are used to compare to the data. Calculati…
Noise-induced behavioral change driven by transient chaos
2022
We study behavioral change in the context of a stochastic, non-linear consumption model with preference adjusting, interdependent agents. Changes in long-run consumption behavior are modelled as noise induced transitions between coexisting attractors. A particular case of multistability is considered: two fixed points, whose immediate basins have smooth boundaries, coexist with a periodic attractor, with a fractal immediate basin boundary. If a trajectory leaves an immediate basin, it enters a set of complexly intertwined basins for which final state uncertainty prevails. The standard approach to predicting transition events rooted in the stochastic sensitivity function technique due to Mil…
A systematic review and combined analysis of therapeutic drug monitoring studies for longacting risperidone
2017
Introduction: This systematic review of therapeutic drug monitoring (TDM) identifies three long-acting injectable (LAI) risperidone formulations. Areas covered: Limited data is available on two formulations (RBP-7000 and in Situ Microparticle), but 20 TDM articles on the microsphere formulation were found. Risperidone TDM includes the serum concentrations of risperidone and its active metabolite, 9-hydroxyrisperidone, used for calculating: 1) the risperidone/9-hydroxyrisperidone (R/9-OH-R) ratio (a measure of CYP2D6; values >1 are indicative of a CYP2D6 poor metabolizer) and 2) the total risperidone concentration-to-dose (C/D) ratio (a measure of risperidone clearance with a normal value…
Prioritization of high-cost new drugs for HCV: making sustainability ethical
2016
Hepatitis C virus (HCV) infection is a major health problem worldwide. Chronic HCV infection may in the long run cause cirrhosis, hepatic decompensation and hepatocellular carcinoma, with an ultimate disease burden of at least 350,000 deaths per year worldwide. The new generation of highly effective direct acting antivirals (DAA) to treat HCV infection brings major promises to infected patients in terms of exceedingly high rates of sustained virological response (SVR) but also of tolerability, allowing even the sickest patients to be treated. Even in the face of the excellent safety and efficacy and wide theoretical applicability of these regimens, their introduction is currently facing cos…
High expression of QSOX1 reduces tumorogenesis, and is associated with a better outcome for breast cancer patients.
2012
International audience; ABSTRACT: INTRODUCTION: The gene quiescin/sulfhydryl oxidase 1, QSOX1, encodes an enzyme directed to the secretory pathway and excreted into the extracellular space. QSOX1 participates in the folding and stability of proteins and thus could regulate the biological activity of its substrates in the secretory pathway and/or outside the cell. The involvement of QSOX1 in oncogenesis has been studied primarily in terms of its differential expression in systemic studies. QSOX1 is overexpressed in prostate cancers and in pancreatic adenocarcinoma. In contrast, QSOX1 gene expression is repressed in endothelial tumors. In the present study, we investigated the role of QSOX1 i…
Pumice powder as filler of self-compacting concrete
2015
Abstract An experimental study on the rheological and mechanical properties of self-compacting concrete with pumice powder used as filler additive is presented. Self-compacting concrete (SCC) shows its peculiar characteristics in the fresh state and many researches have been developed with reference to its rheological characteristics paying attention to the techniques of self-compacting properties assessment. One of the most important aspect in concrete mix-design is the type and the amount of fillers with respect to water and cement: this amount has great influence not only on self-compacting properties (fluidity, segregation, etc.), but also on the mechanical properties of the mixture. Vo…
Molecular evidence for the inverse comorbidity between central nervous system disorders and cancers detected by transcriptomic meta-analyses.
2014
There is epidemiological evidence that patients with certain Central Nervous System (CNS) disorders have a lower than expected probability of developing some types of Cancer. We tested here the hypothesis that this inverse comorbidity is driven by molecular processes common to CNS disorders and Cancers, and that are deregulated in opposite directions. We conducted transcriptomic meta-analyses of three CNS disorders (Alzheimer's disease, Parkinson's disease and Schizophrenia) and three Cancer types (Lung, Prostate, Colorectal) previously described with inverse comorbidities. A significant overlap was observed between the genes upregulated in CNS disorders and downregulated in Cancers, as wel…
Una postilla su una delle novità introdotte dall’art. 84 del codice dei contratti pubblici (d.lgs. n. 50/2016). L’obbligo delle stazioni appaltanti d…
2016
A NOTE ON ONE OF THE NEW MEASURES INTRODUCED BY ARTICLE 84 OF THE ITALIAN PUBLIC PROCUREMENTS CODE (LEGISLATIVE DECREE NO 50/2016). THE OBLIGATION OF CONTRACTING AUTHORITIES TO VERIFY THE QUALIFICATION CERTIFICATE OF CONTRACTORS ISSUED BY SOA Article 84 of the new Italian Public Procurements Code, which (along with other provisions) sets out the qualification system for economic operators offering the execution of works for an amount equal to or over 150,000 Euro, introduces several new provisions. In addition to the widely publicised and certainly significant one attributing broad regulatory powers to ANAC (the Italian Independent Authority supervising public procurements), Article 84 impo…
Nonmonotonic behavior of spatiotemporal pattern formation in a noisy Lotka-Volterra system
2004
The noise-induced pattern formation in a population dynamical model of three interacting species in the coexistence regime is investigated. A coupled map lattice of Lotka-Volterra equations in the presence of multiplicative noise is used to analyze the spatiotemporal evolution. The spatial correlation of the species concentration as a function of time and of the noise intensity is investigated. A nonmonotonic behavior of the area of the patterns as a function of both noise intensity and evolution time is found.
Numerical and Experimentical Study of Motion Control Using Pressure Feedback
2013
This paper is concerned with the inherent oscillatory nature of pressure compensated motion control of a hydraulic cylinder subjected to a negative load and suspended by means of an overcenter valve. A pressure feedback scheme that indirectly eliminates the oscillations is investigated. The indirect control scheme utilizes pressure feedback to electronically compensate the metering-out allowing for the removal of the compensator and, subsequently, elimination of the oscillations. The suggested electronic compensation scheme is implemented and examined in a single degree-of-freedom test rig actuated by means of a double acting hydraulic cylinder. The control scheme is compared with other con…