Search results for "actions"
showing 10 items of 2898 documents
Interactions, spillovers de connaissance et croissance des économies modernes. Faut-il préférer la globalisation ou la proximité géographique ?
2009
Globalisation and metropolisation in modern economies induce some locational strategies of knowledge based activities towards cities and deeply increase trade and move of ideas across cities. In that context, we study the way knowledge spillovers have influenced the economic growth of 82 European Metropolises over the 1990-2005 period. We model knowledge spillovers across cities according to three specific interaction patterns depending either on geography or on global advanced services or thought a combination of these patterns. We show that the mixed pattern matters the best for economic growth of cities in Europe.
Identification et caractérisation de candidats d’origine naturelle à action herbicide pour contrôler les adventices
2016
EASPEIPMGESTADAGROSUPINRA; The use of herbicides to control weeds is very common. However, some herbicides are both environmentally detrimental and human unhealthy. The use of microorganisms acting as natural herbicide could be an alternative control method. Symptomatic weeds will be collected in field. Microorganisms will be isolated from symptomatic weeds, purified, identified and inoculated on weeds to confirm Koch’s postulates. The identified pathogenic microorganisms will be tested against a selection of weeds and crops to characterize the host range and the specificity of these microorganisms. In parallel, the diversity of endophytic microorganisms of symptomatic weeds will be charact…
Case-specific performance of MM-PBSA, MM-GBSA, and SIE in virtual screening.
2015
In drug discovery the reliable prediction of binding free energies is of crucial importance. Methods that combine molecular mechanics force fields with continuum solvent models have become popular because of their high accuracy and relatively good computational efficiency. In this research we studied the performance of molecular mechanics generalized Born surface area (MM-GBSA), molecular mechanics Poisson-Boltzmann surface area (MM-PBSA), and solvated interaction energy (SIE) both in their virtual screening efficiency and their ability to predict experimentally determined binding affinities for five different protein targets. The protein-ligand complexes were derived with two different app…
Relations between teacher-child interactions and children's learning and motivation in Finnish kindergartens
2012
Sustainability Development in Mathematics Education : A Case Study of What Kind of Meanings Do Prospective Class Teachers Find for the Mathematical S…
2019
In this article, our focus is on sustainable development in mathematics education from the point of view of teacher training. The aim was to develop prospective teachers’ content knowledge and pedagogical content knowledge of school mathematics. As a case study, we chose the mathematical symbol “a/b”, and examined how prospective class teachers in Finland connect it to the concepts of fraction, ratio, division, rational number or probability. Mathematics textbooks often have a central role in lessons, and they affect strongly how pupils understand concepts and the relationships between them. We chose languaging as a multi-semiotic approach to interpreting what kind of meanings the prospecti…
Evidence of Partial Seniority Conservation in the pi g9/2 Shell for the N=50 Isotones
2022
The reduced transition probabilities for the 4-> and 2->0 transitions in 92Mo and 94Ru and for the 4->2 and 6->4 transitions in 90Zr have been determined in this experiment making use of a multinucleon transfer reaction. These results have been interpreted on the basis of realistic shell-model calculations in the f5/2, p3/2, p1/2, and g9/2 proton valence space. Only the combination of extensive lifetime information and large scale shell-model calculations allowed the extent of the seniority conservation in the N=50 g9/2 orbital to be understood. The conclusion is that seniority is largely conserved in the first πg9/2 orbital.
Practical Considerations for the Daratumumab Management in Portuguese Routine Clinical Practice: Recommendations From an Expert Panel of Hematologists
2022
The recent therapeutic progress in multiple myeloma (MM) has led to the introduction of novel and highly potent drug classes. Daratumumab was the first CD38-targeting antibody showing to be effective and safe in MM patients as monotherapy and in combination regimens, which led to its rapid implementation in clinical practice. Considering that treatment discontinuation for drug-related adverse events can impact patients’ quality of life and outcomes, the treatment decision should consider different factors and be weighted for each patient individually. Here, we aimed to guide clinicians using daratumumab treatment for MM by addressing practical real-world considerations based on an expert pa…
Conceptualizing ecosystem tipping points within a physiological framework
2017
Connecting the nonlinear and often counterintuitive physiological effects of multiple environmental drivers to the emergent impacts on ecosystems is a fundamental challenge. Unfortunately, the disconnect between the way “stressors” (e.g., warming) is considered in organismal (physiological) and ecological (community) contexts continues to hamper progress. Environmental drivers typically elicit biphasic physiological responses, where performance declines at levels above and below some optimum. It is also well understood that species exhibit highly variable response surfaces to these changes so that the optimum level of any environmental driver can vary among interacting species. Thus, specie…
Exercise medicine for cancer cachexia: targeted exercise to counteract mechanisms and treatment side effects.
2022
Abstract Purpose Cancer-induced muscle wasting (i.e., cancer cachexia, CC) is a common and devastating syndrome that results in the death of more than 1 in 5 patients. Although primarily a result of elevated inflammation, there are multiple mechanisms that complement and amplify one another. Research on the use of exercise to manage CC is still limited, while exercise for CC management has been recently discouraged. Moreover, there is a lack of understanding that exercise is not a single medicine, but mode, type, dosage, and timing (exercise prescription) have distinct health outcomes. The purpose of this review was to examine the effects of these modes and subtypes to identify the most opt…
Interaction of allopurinol with phenprocoumon in man.
1977
Conditions in two patients on long-term phenprocoumon (Marcumar®) treatment are reported who had signs of phenprocoumon overdosage when given simultaneously allopurinol. The determination of phenprocoumon plasma concentrations in one patient showed that phenprocoumon accumulates for several weeks during treatment with allopurinol. Signs of phenprocoumon overdosage thus can appear long time after starting allopurinol treatment.