Search results for "active"
showing 10 items of 5361 documents
Osoby będące pod wpływem działania substancji psychoaktywnych a bezradność
2022
The chapter discusses the main concepts related to addiction and its diagnosis. The definition of addiction and diagnostic criteria for substance and behavior addiction will be discussed. Formal criteria enabling professional treatment and social understanding of the phenomenon are important for systematising knowledge and clearly presenting the profiles of addicts. The text describes separately the problem of addictions to behavior, listing those most common in the literature. In addition, a discussion is initiated on behaviors that formally do not meet the definition of addiction, although they are associated with some compulsion. In addition, the issues of the experience of the disease a…
Estar al otro lado de la mesa. Profesionales de los servicios públicos de empleo ante los dilemas de la activación laboral
2019
Under the paradigm of activation, the Public Employment Services has been reshaped by two levels of contractualization. On one hand, the collaboration of the administration with a network of agents on the programme scheme that make up the active policies of employment. On the other hand, the unemployed person?s access to a compartmentalized offer of services and individually taking responsibility for finding work. This double contractualization reveals redefinition of lowering public responsibility faced with the problem of unemployment that this activation supposes. This paper analyses how this redesign has an impact on how professionals serve the unemployed population. This lays bare, in …
Aplidin® induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 ph…
2006
Aplidin® is an antitumor agent in phase II clinical trials that induces apoptosis through the sustained activation of Jun N-terminal kinase (JNK). We report that Aplidin® alters glutathione homeostasis increasing the ratio of oxidized to reduced forms (GSSG/GSH). Aplidin® generates reactive oxygen species and disrupts the mitochondrial membrane potential. Exogenous GSH inhibits these effects and also JNK activation and cell death. We found two mechanisms by which Aplidin® activates JNK: rapid activation of Rac1 small GTPase and downregulation of MKP-1 phosphatase. Rac1 activation was diminished by GSH and enhanced by L-buthionine (SR)-sulfoximine, which inhibits GSH synthesis. Downregulatio…
Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis.
2005
Objective— Sedentary lifestyle is associated with increased cardiovascular events. The underlying molecular mechanisms are incompletely understood. Reactive oxygen species (ROS) contribute to endothelial dysfunction and atherosclerosis. An important source of vascular ROS is the NADPH oxidase. Methods and Results— C57BL6 mice were subjected to regular housing (physical inactivity) or voluntary training on running wheels (6 weeks). Inactivity increased vascular lipid peroxidation to 148±9% and upregulated superoxide release to 176±17% (L-012 chemiluminescence) and 188±29% (cytochrome C reduction assay), respectively. ROS production was predominantly increased in the endothelium and the medi…
Durcissement aux radiations de fibres optiques dopées terres rares et d'amplificateurs 'a fibres optiques
2011
National audience; Cette étude vise à comprendre les effets d'une irradiation Ȗ sur les propriétés optiques et structurales des fibres dopées aux Terres Rares en vue de leur utilisation dans des amplificateurs à fibre réalisés pour des applications spatiales. L'enjeu majeur de durcissement de ces composants est abordé via des techniques telles que le chargement en hydrogène et/ou le co-dopage au Cérium du cœur des fibres optiques. L'identification des centres responsables de l'atténuation induite par irradiation et la compréhension des mécanismes de dégradation mis en jeu sont des étapes indispensables au développement de ces fibres.
Healthy mistrust or complacent confidence? : Civic vigilance in the reporting by leading newspapers on nuclear waste disposal in Finland and France
2021
Trust and confidence have been identified as crucial for efforts at solving the conundrum of high-level radioactive waste management (RWM). However, mistrust has its virtues, especially in the form of “civic vigilance”—healthy suspicion towards the powers that be. This article examines civic vigilance in the form of “watchdog journalism,” as practiced by the leading Finnish and French newspapers—Helsingin Sanomat (HS) and Le Monde (LM)—in their RWM reporting. Although both countries are forerunners in RWM, Finland constitutes a Nordic “high-trust society” while France has been characterized as a “society of mistrust.” Employing the methods of frame analysis, key RWM-related news frames were…
Using Talking Books to Support Early Reading Development
2009
This chapter explores the question of how interactive multimedia talking books can promote young children’s literacy development. Whilst commercially available talking books can motivate young children to read, there is little evidence that they are linked to the development of skills known to promote reading itself. The ‘Bangers and Mash’ talking books (Chera, 2000), were designed to address this issue, and we review studies that evaluated their effectiveness as classroom resources that could promote reading-related skills and abilities. We then consider the various barriers to collaborative learning in Early Years classrooms, and describe how resources like talking books could address som…
A GEM-TPC in twin configuration for the Super-FRS tracking of heavy ions at FAIR
2018
The GEM-TPC [1] described herein will be part of the standard beam-diagnostics equipment of the Super-FRS [2] . This chamber will provide tracking information for particle identification at rates up to 1 MHz on an event-by-event basis. The key requirements of operation for these chambers are: close to 100% tracking efficiency under conditions of high counting rate, spatial resolution below 1 mm and a superb large dynamic range covering projectiles from Z=1 up to Z=92. The current prototype consists of two GEM-TPCs inside a single vessel, which are operating independently and have electrical drift fields in opposite directions. The twin configuration is done by flipping one of the GEM-TPCs o…
Transport and extraction of radioactive ions stopped in superfluid helium
2003
A new approach to convert a high energy beam to a low energy one, which is essential for the next generation radioactive ion beam facilities, has been proposed and tested at Jyvaskyla, Finland. An open Ra-223 alpha-decay-recoil source has been used to produce radioactive ions in superfluid helium. The alpha spectra demonstrate that the recoiling Rn-219 ions have been extracted out of liquid helium. This first observation of the extraction of heavy positive ions across the superfluid helium surface was possible thanks to the high sensitivity of radioactivity detection. An efficiency of 36% was obtained for the ion extraction out of liquid helium. (C) 2003 Elsevier Science B.V. All rights res…
Use of fragmentation beams at LNS with CHIMERA detector
2012
The recent intensity upgrade of the LNS fragmentation beam is discussed. The available beams, the tagging procedures and details on the beam quality are reported. The experimental program started with the CHIMERA detector using such beams is also discussed with preliminary results and future perspectives. © Owned by the authors, 2012.