Search results for "activity"

SYNTHESIS AND ANTITUMOR ACTIVITY OF NEW PYRROLO[2,1-c][1,4]BENZOXAZINES

2009

Stabilized Naked Sub-nanometric Cu Clusters within a Polymeric Film Catalyze C-N, C-C, C-O, C-S, and C-P Bond-Forming Reactions

2015

[EN] Sub-nanometric Cu clusters formed by endogenous reduction of Cu salts and Cu nanoparticles are active and selective catalysts for C−N, C−C, C−O, C−S, and C−P bond-forming reactions. Sub-nanometric Cu clusters have also been generated within a polymeric film and stored with full stability for months. In this way, they are ready to be used on demand and maintain high activity (TONs up to 104 ) and selectivity for the above reactions. A potential mechanism for the formation of the sub-nanometric clusters and their electronic nature is presented.

Nitensidine A, a guanidine alkaloid from Pterogyne nitens, is a novel substrate for human ABC transporter ABCB1.

2014

The Pterogyne nitens (Fabaceae) tree, native to South America, has been found to produce guanidine alkaloids as well as bioactive flavonols such as kaempferol, quercetin, and rutin. In the present study, we examined the possibility of interaction between human ATP-binding cassette (ABC) transporter ABCB1 and four guanidine alkaloids isolated from P. nitens (i.e., galegine, nitensidine A, pterogynidine, and pterogynine) using human T cell lymphoblast-like leukemia cell line CCRF-CEM and its multi-drug resistant (MDR) counterpart CEM/ADR5000. In XTT assays, CEM/ADR5000 cells were resistant to the four guanidine alkaloids compared to CCRF-CEM cells, although the four guanidine alkaloids exhibi…

AZAINDOLO-FUSED HETEROCYCLES: SYNTHESIS AND ANTITUMOR ACTIVITY

2008

Low temperature rate coefficients of the H + CH+ → C+ + H2 reaction: New potential energy surface and time-independent quantum scattering

2015

The observed abundances of the methylidyne cation, CH(+), in diffuse molecular clouds can be two orders of magnitude higher than the prediction of the standard gas-phase models which, in turn, predict rather well the abundances of neutral CH. It is therefore necessary to investigate all the possible formation and destruction processes of CH(+) in the interstellar medium with the most abundant species H, H2, and e(-). In this work, we address the destruction process of CH(+) by hydrogen abstraction. We report a new calculation of the low temperature rate coefficients for the abstraction reaction, using accurate time-independent quantum scattering and a new high-level ab initio global potenti…

La educación para la salud en la escuela en la adquisicion de estilos de vida saludables

2013

ABSTRACT: The main objective of ESP is to develop activities and encourage the students to achieve the highest attainable standard of health, through the acquisition of knowledge and skills that promote choice and adoption of healthy lifestyles, seeking the participation, the interaction and social integration and the ability to work critically and creatively, and the search for solutions. Promotion and Health Education developed from Schools is one of the key tools of health interventions. Access to children and young people is almost complete because of the obligatory education. In the period of the obligatory people education are more receptive for the learning, being the period of the v…

La Promoción y Educación para la Salud desarrollada desde los centros educativos como herramienta clave de las intervenciones de salud

2012

ABSTRACT Promotion and Health Education developed from Schools is one of the key tools of health interventions. Access to children and young people is almost complete because of the obligatory education. In the period of the obligatory people education are more receptive for the learning, being the period of the vital development in which acquire major life habits that are consolidated with the years (physical activity, food, etc.) It also is an area of social intervention that counts with health workers who have high qualifications from the pedagogical point of view. In this context, the main objective of ESP is to develop activities and encourage the students to achieve the highest attain…

La educación para la salud en la escuela como intervención social

2013

ABSTRACT Schools with families are socializing areas where it takes place the development of people in their early stages, exerting an important role in the configuration of behavior and social values of children and adolescents. When we consider the health as understood by the WHO, that is, as a state of complete physical, mental and social wellness and not only as the absence of disease we see that the attainment of good educational results by a school save a very close relationship with the attainment of optimal levels of health within the educational community. According to this fact schools that incorporate the health promotion as part of its educational are building the bases that wil…

Estimation of ADME Properties in Drug Discovery: Predicting Caco-2 Cell Permeability Using Atom-Based Stochastic and Non-stochastic Linear Indices

2007

The in vitro determination of the permeability through cultured Caco-2 cells is the most often-used in vitro model for drug absorption. In this report, we use the largest data set of measured P(Caco-2), consisting of 157 structurally diverse compounds. Linear discriminant analysis (LDA) was used to obtain quantitative models that discriminate higher absorption compounds from those with moderate-poorer absorption. The best LDA model has an accuracy of 90.58% and 84.21% for training and test set. The percentage of good correlation, in the virtual screening of 241 drugs with the reported values of the percentage of human intestinal absorption (HIA), was greater than 81%. In addition, multiple …

Synthesis, structural diversity, inter-conversion and reactivity of Cu(II) complexes of hydroxy-rich molecules

2002

Tetranuclear Cu(II) complexes having linear, cubane and pseudodouble-cubane cores were synthesized using hydroxy-rich molecules possessing amine and imine groups. The products were structurally characterized and were studied for their ability to oxidize catechol as well as for their inter-conversion between mono- and tetra-nuclear complexes.