Search results for "actors"
showing 10 items of 11323 documents
Endoderm development requires centrioles to restrain p53-mediated apoptosis in the absence of ERK activity
2021
Centrioles comprise the heart of centrosomes, microtubule-organizing centers. To study the function of centrioles in lung and gut development, we genetically disrupted centrioles throughout the mouse endoderm. Surprisingly, removing centrioles from the endoderm did not disrupt intestinal growth or development but blocked lung branching. In the lung, acentriolar SOX2-expressing airway epithelial cells apoptosed. Loss of centrioles activated p53, and removing p53 restored survival of SOX2-expressing cells, lung branching, and mouse viability. To investigate how endodermal p53 activation specifically killed acentriolar SOX2-expressing cells, we assessed ERK, a prosurvival cue. ERK was active t…
Association between socioeconomic factors and origin of hospital referrals among patients with oral cancer.
2022
The Brazilian Unified Health System (SUS) is responsible for offering free assistance to more than 100 million Brazilians, including treatment of oral cancer lesions. Considering that the Brazilian public system aids the most vulnerable population, this study analyzed whether the origin of hospital referrals of patients with oral cancer is associated with socioeconomic factors. A cross-sectional study was carried out from cancer hospital records of the National Cancer Institute (RHC-INCA), considering the primary locations (C00 to C06) diagnosed between 2016 and 2019. Data on gender, skin color (white and non-white), education (no schooling, incomplete or complete elementary education; high…
The Spatial Extent of Pain Is Associated with Pain Intensity, Catastrophizing and Some Measures of Central Sensitization in People with Frozen Should…
2021
The aim of this cross-sectional study was to explore the spatial extent of pain and its association with clinical symptoms, psychological features, and pain sensitization in people with frozen shoulder (FS). Forty-eight individuals with FS completed pain drawings (PDs) and reported their clinical symptoms including pain intensity (Visual Analogue Scale) and shoulder disability (Shoulder Pain and Disability Index). Moreover, pain sensitization measurements (pressure pain thresholds, temporal summation, conditioned pain modulation, and Central Sensitization Inventory (CSI)) were assessed. Psychological features were assessed by Pain Catastrophizing Scale (PCS) and Pain Vigilance and Awareness…
Evolutionary Dynamics of Pathoadaptation Revealed by Three Independent Acquisitions of the VirB/D4 Type IV Secretion System in Bartonella
2017
The α-proteobacterial genus Bartonella comprises a group of ubiquitous mammalian pathogens that are studied as a model for the evolution of bacterial pathogenesis. Vast abundance of two particular phylogenetic lineages of Bartonella had been linked to enhanced host adaptability enabled by lineage-specific acquisition of a VirB/D4 type IV secretion system (T4SS) and parallel evolution of complex effector repertoires. However, the limited availability of genome sequences from one of those lineages as well as other, remote branches of Bartonella has so far hampered comprehensive understanding of how the VirB/D4 T4SS and its effectors called Beps have shaped Bartonella evolution. Here, we repor…
Additional file 1: of An SNP-based saturated genetic map and QTL analysis of fruit-related traits in Zucchini using Genotyping-by-sequencing
2017
Phenotyped traits in the RIL population. (DOCX 13 kb)
Additional file 2 of Interleukin-25-mediated resistance against intestinal trematodes does not depend on the generation of Th2 responses
2020
Additional file 2: Fig. S1. Treatment of mice with rIL-4 or rIL-13 induces a Th2 response and RELM-β overexpression in response to primary Echinostoma caproni and infection but not resistance to infection. (A) expression of cytokine mRNA in the intestinal tissue of rIL-4-treated or rIL-13-treated mice at 2 weeks post-primary infection with E. caproni; (B) expression of RELM-β mRNA in the intestinal tissue (F) of naïve mice, non-infected rIL-4- or rIL-13-treated mice and infected rIL-4- or rIL-13-treated mice at 2 weeks post-primary infection. The relative quantities (RQ) of cytokine genes are shown after normalization with β-actin and standardization of the relative amount against day 0 sam…
The parental bond, resistance to peer influence and risky driving in adolescence
2014
The present study examined the relations between gender, the parental bond, resistance to peer influence, and risky driving. In particular, the mediating role of resistance to peer pressure in the relationship between parental bond and risky driving was examined. The moderating role of gender on these associations was also investigated. The sample comprised 322 adolescents (136 males and 186 females), aged from 16 to 20 years, who were living in northern Italy. Path analysis results showed that the maternal bond only indirectly influenced adolescents’ risky driving, via resistance to peer influence. On the contrary, the paternal bond was neither directly nor indirectly associated with risky…
The lived experience of rescuing people who have driven into floodwater: Understanding challenges and identifying areas for providing support.
2018
Background: Drowning is a major public health issue, with risk increasing during times of flood. Driving into floodwater is a major risk factor for flood-related drowning and injury, and despite widespread public health campaigns, many people continue to undertake this risky behaviour and require rescue. Purpose: We aimed to identify key challenges faced by emergency services personnel when rescuing those who have driven into floodwater, and to identify strategies for supporting rescuers in this important role. Methods: Australian flood rescue operators (N = 8) who had previously rescued a driver who had driven into floodwater participated in semi-structured interviews. Data were analysed u…
Tourism product/ service attribute influence on overall tourist satisfaction level in Riga
2019
Tourist satisfaction is significant for successful destination marketing as it affects the choice of destination, consumption of tourism products and services as well as the decision to return to the destination and intentions to recommend the destination to other potential tourists. The mutual positive influence of customer satisfaction and loyalty is indisputably proven by empirical research studies carried out in different economic fields and industries, including tourism. The aim of the research was to study the satisfaction level of foreign tourists as consumers with various tourism product attributes in Riga and its influence on overall satisfaction and further consumer behaviour of t…
La Aceptación Familiar y la Conducta Prosocial: el Rol de los Factores de Personalidad en Menores con Medidas de Internamiento Judicial
2021
espanolEn la presente investigacion se analiza la relacion entre el sentimiento de aceptacion familiar y las distintas dimensiones de la conducta prosocial en menores infractores en regimen de internamiento. El interes esta tambien en determinar el rol mediador y moderador que tienen los factores de personalidad (modelo de los “cinco grandes”) en la relacion entre el sentimiento de aceptacion familiar y la conducta prosocial. La muestra esta formada por 162 menores infractores con edades entre los 14 y los 22 anos (M = 17.10, DT = 1.41), con medida judicial de internamiento en centros de la Comunidad Autonoma de Madrid (Espana). Los resultados obtenidos indican que no hay una relacion direc…