Search results for "acute respiratory distress syndrome"

showing 10 items of 30 documents

Rationale and evidence on the use of tocilizumab in COVID-19: a systematic review

2020

Abstract Background Tocilizumab is an IL-6 receptor-blocking agent proposed for the treatment of severe COVID-19. The aim of this systematic review was to describe the rationale for the use of tocilizumab for the treatment of COVID-19 and to summarize the available evidence regarding its efficacy and safety. Methods MEDLINE, PubMed, EMBASE, pre-print repositories (bioRxiv and medRxiv) and two trial Registries were searched for studies on the use of tocilizumab in COVID-19 or SARS-CoV-2 infection, viral pneumonia, and/or sepsis until 20th June 2020. Results We identified 3 indirect pre-clinical studies and 28 clinical studies including 5776 patients with COVID-19 (13 with a comparison group,…

Coronavirus COVID-19 Pneumonia SARS-CoV-2 TocilizumabGCA Giant cell arteritispJIA Pediatric juvenile idiopathic arthritislaw.inventionchemistry.chemical_compound0302 clinical medicineRandomized controlled triallawMedicine030212 general & internal medicineClinical efficacyCPAP Continuous positive airway pressureCOVID-19 Coronavirus disease 2019IDSA Infectious Diseases Society of AmericaRA Rheumatoid arthritisTocilizumabIMV Invasive mechanical ventilationsJIA Juvenile idiopathic arthritisAIFA Agenzia Italiana del FarmacoPulmonary and Respiratory Medicinemedicine.medical_specialtyCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)MEDLINEAntibodies Monoclonal HumanizedNIH U.S. National Institutes of HealthArticleWHO World Health OrganizationSIMIT Italian Society of Infectious and Tropical disease03 medical and health sciencesTocilizumabARDS Acute respiratory distress syndromeAnimalsHumansIn patientIntensive care medicineTocilizumab ; COVID-19 ; Pneumonia ; SARS-CoV-2 ; Coronaviruslcsh:RC705-779business.industryCRS CAR-T cell-induced cytokine release syndromeInterleukin-6SARS-CoV-2NIV Noninvasive mechanical ventilationTNF Tumor necrosis factorCOVID-19Pneumonialcsh:Diseases of the respiratory systemCOVID-19 Drug TreatmentClinical trialCoronavirus030228 respiratory systemchemistrybusinessICTRP International Clinical Trials Registry PlatformPulmonology
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Nanomedicine: A Diagnostic and Therapeutic Approach to COVID-19

2021

The SARS-CoV-2 virus is causing devastating morbidity and mortality worldwide. Nanomedicine approaches have a high potential to enhance conventional diagnostics, drugs and vaccines. In fact, lipid nanoparticle/mRNA vaccines are already widely used to protect from COVID-19. In this review, we present an overview of the taxonomy, structure, variants of concern, epidemiology, pathophysiology and detection methods of SARS-CoV-2. The efforts of repurposing, tailoring, and adapting pre-existing medications to battle COVID-19 and the state of vaccine developments are presented. Next, we discuss the broad concepts and limitations of how nanomedicine could address the COVID-19 threat. Nanomaterials …

DrugMedicine (General)Coronavirus disease 2019 (COVID-19)nanotechnologyComputer scienceSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)media_common.quotation_subjectDiagnostic testNanotechnologySARS-CoV-2 virusReviewGeneral Medicineacute respiratory distress syndromesepsisdrug delivery systemsR5-920vaccineMedicineNanomedicineInorganic materialsRepurposingmedia_commonAir filterFrontiers in Medicine
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Lung injury does not aggravate mechanical ventilation-induced early cerebral inflammation or apoptosis in an animal model.

2018

INTRODUCTION:The acute respiratory distress syndrome is not only associated with a high mortality, but also goes along with cognitive impairment in survivors. The cause for this cognitive impairment is still not clear. One possible mechanism could be cerebral inflammation as result of a "lung-brain-crosstalk". Even mechanical ventilation itself can induce cerebral inflammation. We hypothesized, that an acute lung injury aggravates the cerebral inflammation induced by mechanical ventilation itself and leads to neuronal damage. METHODS:After approval of the institutional and state animal care committee 20 pigs were randomized to one of three groups: lung injury by central venous injection of …

MaleARDSCritical Care and Emergency MedicinePulmonologySwinePhysiologymedicine.medical_treatmentVentilator-Induced Lung InjuryInterleukin-1betalcsh:MedicineApoptosisPathology and Laboratory MedicineHippocampusPositive-Pressure RespirationRandom Allocation0302 clinical medicineAnimal CellsImmune PhysiologyMedicine and Health Scienceslcsh:ScienceImmune ResponseAcute Respiratory Distress SyndromeTidal volumeCerebral CortexNeuronsCognitive ImpairmentRespiratory Distress SyndromeInnate Immune SystemMultidisciplinarymedicine.diagnostic_testCognitive NeurologyBrainGeneral MedicineLung InjuryNeurologyAnesthesiaBreathingCytokinesTumor necrosis factor alphamedicine.symptomAnatomyCellular TypesGeneral Agricultural and Biological SciencesResearch ArticleHistologyCognitive NeuroscienceImmunology10208 Institute of NeuropathologyInflammation610 Medicine & healthGenetics and Molecular BiologyGlial Cells1100 General Agricultural and Biological SciencesLung injury03 medical and health sciencesSigns and SymptomsRespiratory Failure1300 General Biochemistry Genetics and Molecular BiologyDiagnostic MedicinemedicineAnimalsMicroglial CellsMechanical ventilationInflammation1000 Multidisciplinarybusiness.industryInterleukin-6Tumor Necrosis Factor-alphalcsh:RBiology and Life Sciences030208 emergency & critical care medicineCell BiologyMolecular Developmentmedicine.diseaseRespiration ArtificialBronchoalveolar lavage030228 respiratory systemImmune SystemCellular NeuroscienceGeneral Biochemistry570 Life sciences; biologyCognitive Sciencelcsh:QbusinessDevelopmental BiologyNeurosciencePloS one
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Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries

2018

Background: To better understand the epidemiology and patterns of tracheostomy practice for patients with acute respiratory distress syndrome (ARDS), we investigated the current usage of tracheostomy in patients with ARDS recruited into the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG-SAFE) study. Methods: This is a secondary analysis of LUNG-SAFE, an international, multicenter, prospective cohort study of patients receiving invasive or noninvasive ventilation in 50 countries spanning 5 continents. The study was carried out over 4 weeks consecutively in the winter of 2014, and 459 ICUs participated. We evaluated the clinical characteris…

MaleARDSInternationality[SDV]Life Sciences [q-bio]humanoslnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]traqueostomíaCritical Care and Intensive Care MedicineSeverity of Illness IndexCohort StudiesPropensity-matched analysi0302 clinical medicineTracheostomyestudios prospectivosEpidemiologyAcute respiratory distress syndrome (ARDS)030212 general & internal medicineProspective Studiespuntuación de propensión10. No inequalityProspective cohort studyestudios de cohortesmediana edadancianoRespiratory Distress SyndromerespiraciónRespirationlcsh:Medical emergencies. Critical care. Intensive care. First aidMiddle Aged3. Good healthIntensive Care UnitsCohortArtificialCritical IllneFemaleAcute respiratory distress syndrome (ARDS); ICU; Propensity-matched analysis; Tracheostomy; Ventilation; Aged; Cohort Studies; Critical Illness; Female; Humans; Intensive Care Units; Internationality; Male; Middle Aged; Propensity Score; Prospective Studies; Respiration Artificial; Respiratory Distress Syndrome Adult; Severity of Illness Index; TracheostomyCohort studyHumanAdultmedicine.medical_specialtyCritical IllnessIntensive Care UnitSocio-culturaleunidades de cuidados intensivosenfermedad críticaPropensity-matched analysis03 medical and health sciencesAcute respiratory distress syndrome (ARDS); ICU; Propensity-matched analysis; Tracheostomy; VentilationSeverity of illnessSettore MED/41 - ANESTESIOLOGIAmedicineHumansíndice de gravedad de la enfermedadPropensity ScoreAgedbusiness.industryResearchRespiratory Distress Syndrome Adultinternacionalidadlcsh:RC86-88.9medicine.diseaseR1Respiration ArtificialVentilationProspective Studie030228 respiratory systemPropensity score matchingEmergency medicineICUObservational studyCohort Studiebusiness
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Death in hospital following ICU discharge: insights from the LUNG SAFE study

2021

Abstract Background To determine the frequency of, and factors associated with, death in hospital following ICU discharge to the ward. Methods The Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE study was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted across 459 ICUs from 50 countries globally. This study aimed to understand the frequency and factors associated with death in hospital in patients who survived their ICU stay. We examined outcomes in the subpopulation discharged with no limitations of life sustaining treatments (‘treatment limitations’), and the subpopulations with tre…

MaleARDSLUNG SAFEhealth care facilities manpower and servicesAcute hypoxemic respiratory failure; Acute respiratory distress syndrome; Hospital survival; ICU discharge; LUNG SAFEKaplan-Meier EstimateCritical Care and Intensive Care MedicineAcute hypoxemic respiratory failure; Acute respiratory distress syndrome; Hospital survival; ICU discharge; LUNG SAFE;0302 clinical medicineRisk Factors030212 general & internal medicineProspective StudiesProspective cohort studyAcute hypoxemic respiratory failureCOPDAcute respiratory distress syndromeICU dischargeMedical emergencies. Critical care. Intensive care. First aidMiddle AgedPatient DischargeLUNG SAFE.Intensive Care Unitsmedicine.anatomical_structureLung safeSOFA scoreFemaleRespiratory InsufficiencyAdultmedicine.medical_specialtyNOHospital survival03 medical and health sciencesSettore MED/41 - ANESTESIOLOGIAmedicineHumansddc:610Risk factorMortalityAgedLungRC86-88.9business.industryResearch030208 emergency & critical care medicinemedicine.diseaseLogistic Modelslnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4]Respiratory failureEmergency medicineObservational studybusiness
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Impact of Early Acute Kidney Injury on Management and Outcome in Patients With Acute Respiratory Distress Syndrome: A Secondary Analysis of a Multice…

2019

Contains fulltext : 208648.pdf (Publisher’s version ) (Closed access) OBJECTIVES: To understand the impact of mild-moderate and severe acute kidney injury in patients with acute respiratory distress syndrome. DESIGN: Secondary analysis of the "Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure", an international prospective cohort study of patients with severe respiratory failure. SETTING: Four-hundred fifty-nine ICUs from 50 countries across five continents. SUBJECTS: Patients with a glomerular filtration rate greater than 60 mL/min/1.73 m prior to admission who fulfilled criteria of acute respiratory distress syndrome on day 1 and day 2 of acute …

MaleARDSmedicine.medical_treatmentComorbidityCritical Care and Intensive Care MedicineSeverity of Illness Indexchemistry.chemical_compound0302 clinical medicineacute kindey faliureRisk FactorsOdds Ratio80 and overHospital MortalityProspective StudiesAged 80 and overRespiratory Distress SyndromeRespirationAcute kidney injuryMiddle Agedacute kidney injury acute respiratory distress syndrome invasive mechanical ventilation mortality renal replacement therapyIntensive Care Unitsacute kidney injuryCreatinineArtificialFemaleGlomerular Filtration RateAdultinvasive mechanical ventilationrenal replacement therapy.medicine.medical_specialtySocio-culturaleRenal functionard03 medical and health sciencesInternal medicineSettore MED/41 - ANESTESIOLOGIASeverity of illnessmedicineHumansacute kidney injury acute respiratory distress syndromeRenal replacement therapyAgedCreatinineRenal replacement therapybusiness.industry030208 emergency & critical care medicineCarbon Dioxideacute respiratory distress syndromemedicine.diseaseRespiration Artificialmortalitylnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4]030228 respiratory systemchemistryRespiratory failurebusinessRespiratory minute volume
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Noninvasive Ventilation of Patients with Acute Respiratory Distress Syndrome: Insights from the LUNG SAFE Study

2016

Rationale: Noninvasive ventilation (NIV) is increasingly used in patients with acute respiratory distress syndrome (ARDS). The evidence supporting NIV use in patients with ARDS remains relatively sparse.Objectives: To determine whether, during NIV, the categorization of ARDS severity based on the PaO2/FiO2 Berlin criteria is useful.Methods: The LUNG SAFE (Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure) study described the management of patients with ARDS. This substudy examines the current practice of NIV use in ARDS, the utility of the PaO2/FiO2 ratio in classifying patients receiving NIV, and the impact of NIV on outcome.Measurements and Main…

MaleARDSprocedureblood oxygen tensionCritical Care and Intensive Care MedicineSeverity of Illness Indexlaw.invention0302 clinical medicinelawHospital MortalityRespiratory Distress SyndromeAcute respiratory distress syndromeadult respiratory distress syndromeMiddle AgedIntensive care unitIntensive Care Unitsmedicine.anatomical_structureTreatment Outcomepriority journalpositive end expiratory pressureNoninvasive ventilationdisease severityFemaletreatment outcome AgedNoninvasive ventilationprospective studyHumanAdultPulmonary and Respiratory Medicinemedicine.medical_specialtycohort analysiIntensive Care Unitdisease classificationAcute respiratory distressArticleNO03 medical and health sciencesacute respiratory distress syndrome; noninvasive ventilationlength of staySeverity of illnessSettore MED/41 - ANESTESIOLOGIAmedicineSequential Organ Failure Assessment ScoreHumansIn patientAcute respiratory distress syndrome; Noninvasive ventilation; Aged; Female; Hospital Mortality; Humans; Intensive Care Units; Male; Middle Aged; Respiratory Distress Syndrome Adult; Severity of Illness Index; Treatment Outcome; Noninvasive Ventilation; Pulmonary and Respiratory Medicine; Critical Care and Intensive Care MedicineIntensive care medicineoutcome assessmentAgedLungbusiness.industryRespiratory Distress Syndrome Adult030208 emergency & critical care medicinemedicine.diseasemajor clinical studymortalityrespiratory tract diseasesbreathing ratemulticenter study030228 respiratory systemincidenceObservational studyobservational studybusinessAcute respiratory distress syndrome; Noninvasive ventilation;
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SARS CoV2 infection _The longevity study perspectives

2021

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MaleAgingssRNA single-stranded RNARFLP restriction fragment length polymorphismHSPs heat shock proteinsReviewPTMs post-translational modificationsSevere Acute Respiratory SyndromeBiochemistryHIV-1 human immunodeficiency virus-1TNF-α tumor necrosis factor-αEC endothelial cells0302 clinical medicineFluAV influenza A virusI insertionMedicineIFN-γ interferon-γDIC disseminated intravascular coagulationPCR Polymerase Chain Reactionmedia_commonAged 80 and overLongevityRBD receptor-binding domainNeurologyLongevity modelMI myocardial infarctionNK natural killerhPIV2 human parainfluenza virus type 2media_common.quotation_subjectResearching genetic basis of resistance and potential pharmacological targetsLongevityDBP diastolic blood pressureNF-Kb nuclear transcription factor kBRANTES regulated upon activation normal T cell expressed and secretedMphi human macrophages03 medical and health sciencesCox 2 cyclooxygenase 2ORF open reading framePT prothrombin timeSettore MED/05 - Patologia ClinicaHumansMolecular BiologyInflammatory genesARDS acute respiratory distress syndromeNO nitric oxideD deletionCpGIs CpG islandsT2DM type 2 diabetes mellitusmedicine.diseaseFDP fibrin degradation products030104 developmental biologySARS CoV2 severe acute respiratory syndrome Coronavirus 2 virusImmunologyBMI body max indexItalian nonagenarians/centenariansRSV respiratory syncytial virusComplication030217 neurology & neurosurgeryMAPK mitogen-activated protein kinaseIP-10 IFN-γ -Inducible Protein 1040301 basic medicineAT1R activity of angiotensin 1 receptorsDCs dentritic cellsSSCP single strand conformation polymorphismACE/DD polymorphism of the angiotensin converting enzymeFGF21 fibroblast growth factor 21TLR4 toll-like receptor 4NAD nicotinamide adenine dinucleotideACE angiotensin-I converting enzymeAT2R activity of angiotensin 2 receptorsCOVID-19 Coronavirus disease 2019Respiratory distressACE2 angiotensin converting enzyme 2MKP-1 mitogen-activated protein kinase phosphatase-1 ()PD protease domainSNP single nucleotide polymorphismEH essential hypertensionTNFR tumor necrosis factor receptorINR international normalized ratio of the prothrombin timePAI-1 plasminogen activator inhibitor-1Ang angiotensinLPS lipopolysaccharideMCP1 monocyte chemoattractant protein-1medicine.symptomaPTT partial thromboplastin timeBiotechnologyDUSP1 dual specificity phosphatase 1Coronavirus disease 2019 (COVID-19)PC prostate cancerRAS renin-angiotensin aldosterone systemCCR5Δ32 genetic variant of chemokine receptorCOVID-19 Researching genetic basis of resistance and potential pharmacological targets Italian nonagenarians/centenarians Longevity modelAsymptomaticSARS-1 severe acute respiratory syndrome virus 1SIRT-1 Sirtuin 1Th1 t-helper lymphocyte type 1Immune systemROS reactive oxygen speciesTGF-β transforming growth factor betaET-1 endothelin-1ComputingMethodologies_COMPUTERGRAPHICSADAM-17 metallopeptidase domain 17business.industrySARS-CoV-2SBP systolic blood pressureCOVID-19HDACs histone deacetylasesComorbidityImmune Systembusiness5-LO lipoxygenase 5Ageing Research Reviews
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Outcomes of Patients Presenting with Mild Acute Respiratory Distress Syndrome: Insights from the LUNG SAFE Study

2019

Editor's Perspective What We Already Know about This Topic Hospital mortality in acute respiratory distress syndrome is approximately 40%, but mortality and trajectory in "mild" acute respiratory distress syndrome (classified only since 2012) are unknown, and many cases are not detected What This Article Tells Us That Is New Approximately 80% of cases of mild acute respiratory distress syndrome persist or worsen in the first week; in all cases, the mortality is substantial (30%) and is higher (37%) in those in whom the acute respiratory distress syndrome progresses Background: Patients with initial mild acute respiratory distress syndrome are often underrecognized and mistakenly considered …

MaleInternationalityRespiratory Distress Syndrome Adultadult respiratory distress syndromeMiddle AgedSeverity of Illness IndexPatient Outcome AssessmentProspective StudieAnesthesiology and Pain MedicineSettore MED/41 - ANESTESIOLOGIAARDSFemaleHospital MortalityAcute Respiratory Distress SyndromeHuman
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Epidemiological characteristics, practice of ventilation, and clinical outcome in patients at risk of acute respiratory distress syndrome in intensiv…

2016

Background Scant information exists about the epidemiological characteristics and outcome of patients in the intensive care unit (ICU) at risk of acute respiratory distress syndrome (ARDS) and how ventilation is managed in these individuals. We aimed to establish the epidemiological characteristics of patients at risk of ARDS, describe ventilation management in this population, and assess outcomes compared with people at no risk of ARDS. Methods PRoVENT (PRactice of VENTilation in critically ill patients without ARDS at onset of ventilation) is an international, multicentre, prospective study undertaken at 119 ICUs in 16 countries worldwide. All patients aged 18 years or older who were rece…

MalePediatricsARDSmedicine.medical_treatmentlaw.inventionPositive-Pressure Respiration0302 clinical medicinelawRisk FactorsPrevalenceventilator–induced lung injuryProspective StudiesHospital MortalityProspective cohort studyTidal volumeeducation.field_of_studyRespiratory Distress SyndromeAcute respiratory distress syndrometidal volumeARDS critically ill ventilationMiddle AgedIntensive care unitIntensive Care UnitsCritical IllneFemaleHumanPulmonary and Respiratory Medicinemedicine.medical_specialtyCritical IllnessPopulationIntensive Care UnitLung injurymechanical ventilationNO03 medical and health sciencesIntensive caremedicineAcute respiratory distress syndrome mechanical ventilation ventilator–induced lung injury tidal volume positive end–expiratory pressureHumansMED/41 - ANESTESIOLOGIAeducationAgedMechanical ventilationbusiness.industryRisk FactorRespiratory Distress Syndrome Adult030208 emergency & critical care medicinemedicine.diseaseRespiration ArtificialMechanical ventilation Acute respiratory failure Acute respiratory distress syndromeProspective Studie030228 respiratory systemEmergency medicinepositive end–expiratory pressurebusiness
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