Search results for "adaptation"

Et si la crise COVID-19 était une opportunité pour les centres de soin et de santé ? La résilience hospitalière à l’ère de télémédecine et de la télé…

2022

La pandémie de la COVID-19 a mis sous tension l’ensemble des secteurs d’activités. Les établissements de soin et de santé ont été extrêmement touchés et particulièrement en Alsace lors de la première vague. Les managers hospitaliers et les professionnels de santé en général ont dû s’adapter pour faire face à cette crise exceptionnelle et inédite. A notre connaissance, très peu de recherches ont étudié la résilience du point de vue des nouvelles pratiques et innovations digitales et ce particulièrement dans les établissements de soin et de santé alsaciens. Afin de comprendre si la crise COVID-19 était une opportunité pour les centres de soin et de santé alsaciens, nous avons mené des entreti…

Downscaling climate change impacts, socio-economic implications and alternative adaptation pathways for islands and outermost regions

2021

Questo libro fornisce una panoramica completa degli scenari futuri del cambiamento climatico e delle problematiche di gestione associate all'impatto del cambiamento climatico sull'economia blu delle isole e delle regioni ultraperiferiche europee. La pubblicazione raccoglie i principali risultati dei risultati della ricerca del progetto Soclimpact, con l'obiettivo di aumentare la consapevolezza sociale tra i responsabili politici e l'industria sulle conseguenze dei cambiamenti climatici a livello locale e fornire informazioni basate sulla conoscenza nella progettazione delle politiche di sostegno, dal livello locale a quello nazionale. This book provides a comprehensive overview of the futur…

Localization of quantitative trait loci for diapause and other photoperiodically regulated life history traits important in adaptation to seasonally …

2015

Seasonally changing environments at high latitudes present great challenges for the reproduction and survival of insects, and photoperiodic cues play an important role in helping them to synchronize their life cycle with prevalent and forthcoming conditions. We have mapped quantitative trait loci (QTL) responsible for the photoperiodic regulation of four life history traits, female reproductive diapause, cold tolerance, egg-to-eclosion development time and juvenile body weight in Drosophila montana strains from different latitudes in Canada and Finland. The F2 progeny of the cross was reared under a single photoperiod (LD cycle 16:8), which the flies from the Canadian population interpret a…

Tumor Hypoxia: Causative Factors, Compensatory Mechanisms, and Cellular Response

2004

Abstract Learning Objectives After completing this course, the reader will be able to: Explain the effect of hypoxia on resistance to treatment. Describe the causes of tumor hypoxia. Characterize cellular response to hypoxia. Access and take the CME test online and receive 1 hour of AMA PRA category 1 credit at CME.TheOncologist.com Hypoxia is a characteristic feature of locally advanced solid tumors resulting from an imbalance between oxygen (O2) supply and consumption. Major causative factors of tumor hypoxia are abnormal structure and function of the microvessels supplying the tumor, increased diffusion distances between the nutritive blood vessels and the tumor cells, and reduced O2 tra…

Comparison of inter- and intraspecies variation in humans and fruit flies

2015

AbstractVariation is essential to species survival and adaptation during evolution. This variation is conferred by the imperfection of biochemical processes, such as mutations and alterations in DNA sequences, and can also be seen within genomes through processes such as the generation of antibodies. Recent sequencing projects have produced multiple versions of the genomes of humans and fruit flies (Drosophila melanogaster). These give us a chance to study how individual gene sequences vary within and between species. Here we arranged human and fly genes in orthologous pairs and compared such within-species variability with their degree of conservation between flies and humans. We observed …

Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload

2012

AIMS: The optic atrophy 1 (OPA1) protein is an essential protein involved in the fusion of the mitochondrial inner membrane. Despite its high level of expression, the role of OPA1 in the heart is largely unknown. We investigated the role of this protein in Opa1(+/-) mice, having a 50% reduction in OPA1 protein expression in cardiac tissue. METHODS AND RESULTS: In mutant mice, cardiac function assessed by echocardiography was not significantly different from that of the Opa1(+/+). Electron and fluorescence microscopy revealed altered morphology of the Opa1(+/-) mice mitochondrial network; unexpectedly, mitochondria were larger with the presence of clusters of fused mitochondria and altered c…

Ion conductance changes associated with spike adaptation in the rapidly adapting stretch receptor of the crayfish.

1975

The time course of the repetitive impulse discharges has been investigated for two high intensities of maintained depolarizing currents, 30 nA and 50 nA, for which the receptor adaptation was complete within 70 msec. The changes in sodium and potassium conductance associated with the decline in spike activity have been analyzed at different instances of time by interrupting in successive experiments the various action potentials in the pulse trains either at the early phase by holding the potential at about -60 mV and recording the inward current (upstroke-gNa) or by evaluating the delayed outward current flowing as the result of a depolarizing voltage pulse which at the end of the action p…

Yeast mRNA cap-binding protein Cbc1/Sto1 is necessary for the rapid reprogramming of translation after hyperosmotic shock.

2011

Global translation is inhibited in Saccharomyces cerevisiae cells under osmotic stress; nonetheless, osmostress-protective proteins are synthesized. We found that translation mediated by the mRNA cap-binding protein Cbc1 is stress-resistant and necessary for the rapid translation of osmostress-protective proteins under osmotic stress.

Role of RCAN1 in stress induced cell adaptation

2012

Exercise and antioxidant supplements in the elderly

2013

Abstract Both exercise and aging increase reactive oxygen species (ROS), which can result in damage to cells. Aging is the result of damage caused by ROS to the mitochondrial genome in post mitotic cells and numerous studies have demonstrated an increase in ROS or their byproducts with exercise. ROS can cause oxidative stress as they overwhelm the antioxidant cellular defenses. Therefore interventions aimed at limiting or inhibiting ROS production, such as supplementation with antioxidant vitamins, should be able to reduce fatigue during muscle contraction and the rate of formation of aging changes with a consequent reduction of the aging rate and disease pathogenesis. However, it has been …