Yeast mRNA cap-binding protein Cbc1/Sto1 is necessary for the rapid reprogramming of translation after hyperosmotic shock.

6533b85bfe1ef96bd12ba2b3

RESEARCH PRODUCT

Yeast mRNA cap-binding protein Cbc1/Sto1 is necessary for the rapid reprogramming of translation after hyperosmotic shock.

Lorena Romero-santacreu Paula Alepuz Elena Garre Nikki De Clercq Per Sunnerhagen Nati Blasco-angulo

subject

Cell Physiology Saccharomyces cerevisiae Proteins Osmotic shock RNA Stability Saccharomyces cerevisiae Cycloheximide Biology 03 medical and health sciences chemistry.chemical_compound Gene Knockout Techniques Eukaryotic translation Osmotic Pressure Stress Physiological Polysome Gene Expression Regulation Fungal Protein biosynthesis RNA Messenger Molecular Biology 030304 developmental biology Cell Nucleus 0303 health sciences Microbial Viability Osmotic concentration 030302 biochemistry & molecular biology EIF4E Nuclear Proteins Translation (biology)Cell Biology Articles Adaptation Physiological Protein Transport Eukaryotic Initiation Factor-4E chemistry Biochemistry RNA Cap-Binding Proteins Polyribosomes Protein Biosynthesis Protein Binding

description

Global translation is inhibited in Saccharomyces cerevisiae cells under osmotic stress; nonetheless, osmostress-protective proteins are synthesized. We found that translation mediated by the mRNA cap-binding protein Cbc1 is stress-resistant and necessary for the rapid translation of osmostress-protective proteins under osmotic stress.

year	journal	country	edition	language
2011-11-11	Molecular biology of the cell

10.1091/mbc.e11-05-0419 https://pubmed.ncbi.nlm.nih.gov/22072789

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