Search results for "agents"

Pyrazolo[3,4-h]quinolin-2-ones with photobiological properties

2012

Physical Agent Modalities in Early Osteoarthritis: A Scoping Review

2021

Early osteoarthritis (EOA) still represents a challenge for clinicians. Although there is no consensus on its definition and diagnosis, a prompt therapeutic intervention in the early stages can have a significant impact on function and quality of life. Exercise remains a core treatment for EOA; however, several physical modalities are commonly used in this population. The purpose of this paper is to investigate the role of physical agents in the treatment of EOA. A technical expert panel (TEP) of 8 medical specialists with expertise in physical agent modalities and musculoskeletal conditions performed the review following the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and …

Deepening Inside the Pictorial Layers of Etruscan Sarcophagus of Hasti Afunei: An Innovative Micro-Sampling Technique for Raman/SERS Analyses

2019

The Hasti Afunei sarcophagus is a large Etruscan urn, made up of two chalky alabaster monoliths. Dated from the last quarter of the third century BC, it was found in 1826 in the small town of Chiusi (Tuscany- Il Colle place) by a landowner, Pietro Bonci Casuccini, who made it part of his private collection. The noble owner&rsquo

Complex formation of copper(II) and cadmium(II) with pectin and polygalacturonic acid in aqueous solution. An ISE-H + and ISE-Me 2+ electrochemical s…

2012

The acid-base properties of pectin and its ability to complex with copper(II) or cadmium(II) were quantitatively determined in order to define the ability of this natural polyelectrolyte to sequester metal ions. Potentiometric measurements carried out at different ionic strengths (0.1 - 0.7 mol L-1, in Na+ ionic medium) allowed us to define the acid-base properties of pectin together with the dependence of the protonation constants on ionic strength and to calculate the protonation constant at infinite dilution. The formation of complex species between pectin and copper(II) or cadmium(II) was investigated potentiometrically (using H+, Cu2+ and Cd2+ Ion Selective Electrodes, ISEs) in NaNO3 a…

Étude et modélisation des impacts des pratiques agricoles sur la dynamique de la distribution des communautés microbiennes des sols à l’échelle du pa…

2021

National audience; Les micro-organismes telluriques, de par leur abondance et leur richesse, jouent un rôle centraldans le fonctionnement des écosystèmes et sont des bioindicateurs intéressants pour évaluerl’impact des pratiques agricoles sur la qualité des sols. L’enjeu est de favoriser leur utilisationpour accompagner l’innovation dans le monde agricole. Cette thèse a pour objectif de permettreune meilleure compréhension des dynamiques spatiales et temporelles des communautésmicrobiennes du sol à l’échelle du paysage. Pour cela, nous proposons de modéliser cesdynamiques et de partager les connaissances aux acteurs du monde agricole via un OAD (outild’aide à la décision). Le paysage de Fén…

Prenatal exposure to diazepam and alprazolam, but not to zolpidem, affects behavioural stress reactivity in handling-naïve and handling-habituated ad…

2002

A gentle long-lasting handling produces persistent neurochemical and behavioural changes and attenuates the impairment in the behavioural reactivity to novelty induced by the prenatal exposure to diazepam (DZ) in adult male rat progeny. This study investigated the consequences of a late prenatal treatment with three GABA/BDZ R agonists (DZ) alprazolam (ALP) and zolpidem (ZOLP)), on different stress-related behavioural patterns, in non-handled (NH), short-lasting handled (SLH) and long-lasting handled (LLH) adult male rats exposed to forced swim test (FST), acoustic startle reflex (ASR) and Vogel test (VT). The effects on motor activity were evaluated in the open field and in the Skinner box…

Estar al otro lado de la mesa. Profesionales de los servicios públicos de empleo ante los dilemas de la activación laboral

2019

Under the paradigm of activation, the Public Employment Services has been reshaped by two levels of contractualization. On one hand, the collaboration of the administration with a network of agents on the programme scheme that make up the active policies of employment. On the other hand, the unemployed person?s access to a compartmentalized offer of services and individually taking responsibility for finding work. This double contractualization reveals redefinition of lowering public responsibility faced with the problem of unemployment that this activation supposes. This paper analyses how this redesign has an impact on how professionals serve the unemployed population. This lays bare, in …

Explainable Fuzzy AI Challenge 2022 : Winner’s Approach to a Computationally Efficient and Explainable Solution

2022

An explainable artificial intelligence (XAI) agent is an autonomous agent that uses a fundamental XAI model at its core to perceive its environment and suggests actions to be performed. One of the significant challenges for these XAI agents is performing their operation efficiently, which is governed by the underlying inference and optimization system. Along similar lines, an Explainable Fuzzy AI Challenge (XFC 2022) competition was launched, whose principal objective was to develop a fully autonomous and optimized XAI algorithm that could play the Python arcade game “Asteroid Smasher”. This research first investigates inference models to implement an efficient (XAI) agent using rule-based …

Aplidin® induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 ph…

2006

Aplidin® is an antitumor agent in phase II clinical trials that induces apoptosis through the sustained activation of Jun N-terminal kinase (JNK). We report that Aplidin® alters glutathione homeostasis increasing the ratio of oxidized to reduced forms (GSSG/GSH). Aplidin® generates reactive oxygen species and disrupts the mitochondrial membrane potential. Exogenous GSH inhibits these effects and also JNK activation and cell death. We found two mechanisms by which Aplidin® activates JNK: rapid activation of Rac1 small GTPase and downregulation of MKP-1 phosphatase. Rac1 activation was diminished by GSH and enhanced by L-buthionine (SR)-sulfoximine, which inhibits GSH synthesis. Downregulatio…

Rac1 protein signaling is required for DNA damage response stimulated by topoisomerase II poisons.

2012

To investigate the potency of the topoisomerase II (topo II) poisons doxorubicin and etoposide to stimulate the DNA damage response (DDR), S139 phosphorylation of histone H2AX (γH2AX) was analyzed using rat cardiomyoblast cells (H9c2). Etoposide caused a dose-dependent increase in the γH2AX level as shown by Western blotting. By contrast, the doxorubicin response was bell-shaped with high doses failing to increase H2AX phosphorylation. Identical results were obtained by immunohistochemical analysis of γH2AX focus formation, comet assay-based DNA strand break analysis, and measuring the formation of the topo II-DNA cleavable complex. At low dose, doxorubicin activated ataxia telangiectasia m…