Search results for "aggregate"

Views from the boundaries: Music streaming revisited

2021

This article explores how Norwegian record label managers understand their current positions and future possibilities in a market that is increasingly driven by on-demand subscription-based streaming. It adds to a growing body of research by adopting a qualitative approach, seeking to describe issues at a personal or company level, and provide nuance and dynamics in a discourse that is often described in dichotomies and on aggregate levels. The article argues that stakeholders have more varied attitudes than simply being for or against the innovation, the new economic models and their eff ects on their own business, and the market in general. It also demonstrates that perceptions change as …

Automatic Counting of Intra-Cellular Ribonucleo-Protein Aggregates in Saccharomyces cerevisiae Using a Textural Approach.

2019

AbstractIn the context of microbiology, recent studies show the importance of ribonucleo-protein aggregates (RNPs) for the understanding of mechanisms involved in cell responses to specific environmental conditions. The assembly and disassembly of aggregates is a dynamic process, the characterization of the stage of their evolution can be performed by the evaluation of their number. The aim of this study is to propose a method to automatically determine the count of RNPs. We show that the determination of a precise count is an issue by itself and hence, we propose three textural approaches: a classical point of view using Haralick features, a frequency point of view with generalized Fourier…

Studio teorico dell’interazione host-guest fra un sistema tubolare ciclopeptidico e la cesio azide

2006

Mapping and holistic design of natural hydraulic lime mortars

2020

Supplementary data to this article can be found online at https://doi.org/10.1016/j.cemconres.2020.106167.

Discretionary fiscal policy over the cycle: new evidence based on the ESCB Disaggregated Approach

2009

This paper explores how discretionary fiscal policies on the revenue side of the government budget have reacted to economic fluctuations in European Union countries. For this purpose, it uses data on legislated revenue changes and structural indicators provided twice per year by National Central Banks of European Union countries in the ESCB framework for analysing fiscal policy. The analysis is based on the estimation of fiscal policy rules linking these measures of legislated fiscal policy changes to the output gap and other control variables. Then, baseline results are compared with regression estimates where variations of cyclically-adjusted indicators are used as proxy for discretionary…

Blue autofluorescence in protein aggregates “lighted on” by UV induced oxidation

2019

Oxidation of amino acid side chains in protein structure can be induced by UV irradiation leading to critical changes in molecular structure possibly modifying protein stability and bioactivity. Here we show, by using a combination of multiple spectroscopic techniques and Fluorescence Lifetime Imaging, that UV-light exposure induces irreversible oxidation processes in Ubiquitin structure. In particular, the growth of a new autofluorescence peak in the blue region is detected, that we attribute to tyrosine oxidation products. Blue autofluorescence intensity is found to progressively increase also during aggregation processes leading to the formation of aggregates of non-amyloid nature. Signi…

Cationic Supramolecular Vesicular Aggregates for Pulmonary Tissue Selective Delivery in Anticancer Therapy

2016

The biopharmaceutical properties of supramolecular vesicular aggregates (SVAs) were characterized with regard to their physicochemical features and compared with cationic liposomes (CLs). Neutral and cationic SVAs were synthesized using two different copolymers of poly(aspartyl hydrazide) by thin-layer evaporation and extrusion techniques. Both copolymers were self-assembled in pre-formulated liposomes and formed neutral and cationic SVAs. Gemcitabine hydrochloride (GEM) was used as an anticancer drug and loaded by a pH gradient remote loading procedure, which significantly increased drug loading inside the SVAs. The resulting average size of the SVAs was 100 nm. The anticancer activity of …

Microstructural analysis of shearband boudin - preliminary results

2011

The internal structure of a shearband boudin resulting from an original igneous, hydrothermal or metamorphic segregation tabular rigid body is a subject of scientific interest. It allows understanding the deformation mechanisms acting on homogeneous quartz aggregate activated during simple shear progressive deformation. This communication is focused on the characterization of two main structural aspects: (i) the existence of different internal domains in shearband boudins; (ii) the development of internal structures related with its genesis and evolution, namely, secondary shear planes c’ type-I and c’ type-II, parameter B-t (mass accumulation sector on blunt tip of shearband boudin) and S-…

ION MOBILITY STUDIES ON SODIUM-BIS (2- ETHYLHEXIL)SULFOSUCCINATE (AOTNa) AGGREGATES

2012

The supramolecular charged aggregates formed during ESI ionization of AOTNa solutions under critical micelle concentration have been studied thorough ion mobility experiments. In particular, positively charged clusters with several charge states, ranging from +1 to +4, have been investigated. It has been found that, despite to previous investigations (Siuzdak et al. 1995, Nohara et al. 1998), specific ionic aggregates with a peculiar cross section are observed. Indeed a single drift time is observed for each charged aggregate. Using both calculated cross section and experimental calibration curves the experimental cross section of the observed cation has been determined. It is worth noting …

Economic globalization and voter turnout in established democracies

2010

This paper asks whether international economic integration negatively affects electoral turnout. The theoretical model builds on the premise that economic integration constrains the ability of national governments to shape outcomes. Citizens are conscious of such constraints and take them into account when considering the costs and benefits of casting a vote in national elections. The result is a lower inclination to vote under conditions of high economic integration. Consequently, aggregate turnout is lower the more internationally integrated a national economy is. Analysis of aggregate data for parliamentary elections in 23 OECD democracies over the period 1965–2006 robustly supports this…