Search results for "aggregation."

Structure-property relationships in aromatic thioethers featuring aggregation-induced emission : Solid-state structures and theoretical analysis

2019

We describe in this paper a structure–property relationship study of aromatic thioethers with aggregation-induced emission (AIE) properties. We combine a structural analysis based on geometrical consideration with an in-depth analysis of the crystalline packing supported by quantum mechanical calculations. Our results allow us to correlate the enhanced fluorescence quantum yields with the significant increase of C–H⋯π and the decrease of π⋯π interactions in the solid state – a result which supports the well-accepted AIE mechanism quantitatively.

Nanovectorization of TRAIL with single wall carbon nanotubes enhances tumor cell killing

2015

International audience; Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL or Apo2L) is a member of the tumor necrosis factor (TNF) superfamily. This type II transmembrane protein is able to bound specifically to cancer cell receptors (i.e., TRAIL-R1 (or DR4) and TRAIL-R2 (or DR5)) and to induce apoptosis without being toxic for healthy cells. Because membrane-bound TRAIL induces stronger receptor aggregation and apoptosis than soluble TRAIL, we proposed here to vectorize TRAIL using single-walled carbon nanotubes (SWCNTs) to mimic membrane TRAIL. Owing to their exceptional and revolutional properties, carbon nanotubes, especially SWCNTs, are used in a wide range of physical or,…

Involving fuzzy orders for multi-objective linear programming

2012

This paper presents a solution approach for multi-objective linear programming problem. We propose to involve fuzzy order relations to describe the objective functions where in ”classical” fuzzy approach the membership functions which illustrate how far the concrete point is from the solution of individual problem are studied. Further the global fuzzy order relation is constructed by aggregating the individual fuzzy order relations. Thus the global fuzzy relation contains the information about all objective functions and in the last step we find a maximum in the set of constrains with respect to the global fuzzy order relation. We illustrate this approach by an example.

A choice of bilevel linear programming solving parameters: factoraggregation approach

2013

Our paper deals with the problem of choosing correct parameters for the bilevel linear program- ming solving algorithm proposed by M. Sakawa and I. Nishizaki. We suggest an approach based on fac- toraggregation, which is a specially designed general aggregation operator. The idea of factoraggregation arises from factorization by the equivalence relation generated by the upper level objective function. We prove several important properties of the factorag- gregation result regarding the analysis of param- eters in order to find an optimal solution for the problem. We illustrate the proposed method with some numerical and graphical examples, in particu- lar we consider a modification of the m…

Greedy versus Dynamic Channel Aggregation Strategy in CRNs: Markov Models and Performance Evaluation

2011

Part 1: - PE-CRN 2011 Workshop; International audience; In cognitive radio networks, channel aggregation techniques which aggregate several channels together as one channel have been proposed in many MAC protocols. In this paper, we consider elastic data traffic and spectrum adaptation for channel aggregation, and propose two new strategies named as Greedy and Dynamic respectively. The performance of channel aggregation represented by these strategies is evaluated using continuous time Markov chain models. Moreover, simulation results based on various traffic distributions are utilized in order to evaluate the validity and preciseness of the mathematical models.

La décomposition canonique et la cointégration

1994

This paper has introduced state space models for cointegrated time series. In doing so, the notion of cointegration is slightly generalized. We develop the notion of dynamic aggregation link with error correction model and common trends.

Cetylpyridinium chloride promotes disaggregation of SARS-CoV-2 virus-like particles

2022

ABSTRACT Background SARS-CoV-2 is continuously disseminating worldwide. The development of strategies to break transmission is mandatory. Aim of the study To investigate the potential of cetylpyridinium chloride (CPC) as a viral inhibitor. Methods SARS-CoV-2 Virus Like-Particles (VLPs) were incubated with CPC, a potent surfactant routinely included in mouthwash preparations. Results Concentrations of 0.05% CPC (w/v) commonly used in mouthwash preparations are sufficient to promote the rupture of SARS-CoV-2 VLP membranes. Conclusion Including CPC in mouthwashes could be a prophylactic strategy to keep SARS-CoV-2 from spreading.

Microscopic Study of Injectable Steroids: Effects of Postmixing Time on Particle Aggregation

2020

Background: Epidural steroid injection (ESI) is a common practice for pain treatment since 1953. In 2014, the FDA issued a warning about ESI. Studies have focused on the effect of the particle size and their ability to generate harmful aggregates. Although steroid aggregates provide longer times for reabsorption, therefore a longer anti-inflammatory effect, they are potentially harmful to the central nervous system via embolic mechanisms. Previous studies have established that steroidal aggregates with asizes over 100 μm are potentially able to occlude blood vessels. Studies by Tiso et al and Benzon et al addressed the role of steroids on CNS adverse events, with similar outcomes. The main …

Low risk of intracranial emergency in patients with minor head injury treated with antiplatelet therapy.

2021

The route to protein aggregate superstructures: Particulates and amyloid-like spherulites.

2015

AbstractDepending on external conditions, native proteins may change their structure and undergo different association routes leading to a large scale polymorphism of the aggregates. This feature has been widely observed but is not fully understood yet. This review focuses on morphologies, physico-chemical properties and mechanisms of formation of amyloid structures and protein superstructures. In particular, the main focus will be on protein particulates and amyloid-like spherulites, briefly summarizing possible experimental methods of analysis. Moreover, we will highlight the role of protein conformational changes and dominant forces in driving association together with their connection w…