Search results for "agile"

Dysregulated Prefrontal Cortex Inhibition in Prepubescent and Adolescent Fragile X Mouse Model

2020

Changes in excitation and inhibition are associated with the pathobiology of neurodevelopmental disorders of intellectual disability and autism and are widely described in Fragile X syndrome (FXS). In the prefrontal cortex (PFC), essential for cognitive processing, excitatory connectivity and plasticity are found altered in the FXS mouse model, however, little is known about the state of inhibition. To that end, we investigated GABAergic signaling in the Fragile X Mental Retardation 1 (FMR1) knock out (Fmr1-KO) mouse medial PFC (mPFC). We report changes at the molecular, and functional levels of inhibition at three (prepubescence) and six (adolescence) postnatal weeks. Functional changes we…

The Large Observatory for X-ray Timing (LOFT)

2012

High-time-resolution X-ray observations of compact objects provide direct access to strong-field gravity, to the equation of state of ultra-dense matter and to black hole masses and spins. A 10 m^2-class instrument in combination with good spectral resolution is required to exploit the relevant diagnostics and answer two of the fundamental questions of the European Space Agency (ESA) Cosmic Vision Theme "Matter under extreme conditions", namely: does matter orbiting close to the event horizon follow the predictions of general relativity? What is the equation of state of matter in neutron stars? The Large Observatory For X-ray Timing (LOFT), selected by ESA as one of the four Cosmic Vision M…

d'Annunzio e i Balletti russi

2010

Agile software development in theory and practice

2002

Composition of a New Process to Meet Agile Needs Using Method Engineering

2005

The need of developing a new software engineering process to allow the quick prototyping of some robotic applications and meet the requests by some companies for a development process that was shorter than PASSI, gave us the opportunity of applying our studies on the assembling of a new SEP by reusing parts (called method fragments) from other processes. In this paper we discuss our approach that, starting from the method engineering paradigm, adapts and extends it considering specific agent-oriented issues like the multi-agent system meta-model. The final result of our experiment (Agile PASSI) is presented together with the requirements that motivated its structure. © Springer-Verlag Berli…

Informatīvā paneļa "InfoDesk" video logrīka izstrāde

2015

Šajā kvalifikācijas darbā ir aprakstīta moduļa “video logrīks” izstrāde priekš informatīvā paneļa InfoDesk. “Video logrīks” papildina sistēmu InfoDesk ar iespēju slaidiem pievienot video un ar to veikt dažādas manipulācijas. InfoDesk ir programma, kas ļauj izveidot informatīvu slaidrādi, tās saturu veidojot no dažādiem elementiem.

Success factors in distributed agile development : case study

2018

This thesis aimed to figure out success factors in distributed software development conducting literature review and empirical research. The motivation for this research rose from practical work experience and the notion that usage of agile development has increased same time as global distributed software development has become more common. The research question formed to investigate the topic was: “What are success factors in distributed agile development and what experiences about this combination already exists?” To answer research question, there were conducted literature review of existing literature and empirical case study research executed using theme interviews. In literature revi…

Sleep phenotypes of intellectual disability: a polysomnographic evaluation in subjects with Down syndrome and Fragile X syndrome

2008

Abstract Objective To analyze sleep architecture and NREM sleep alterations by means of the Cyclic Alternating Pattern (CAP) in children with Down syndrome (DS) and Fragile-X syndrome (fraX), the two most common causes of inherited mental retardation, in order to find out eventual alterations of their sleep microstructure related to their mental retardation phenotypes. Methods Fourteen patients affected by fraX (mean age 13.1 years) and 9 affected by Down syndrome (mean age 13.8 years) and 26 age-matched normal controls were included. All subjects underwent overnight polysomnography in the sleep laboratory, after one adaptation night and their sleep architecture and CAP were visually scored…

Customer data collection infrastructure and Customer Experience Management:The SAQ Case Study

2017

Channel integration makes Customer Experience Management more complex and requires from retailers a regeneration of their value proposition. A longitudinal case study reveal a hierarchical sequence of operant resource triad: cultural mindsets, strategic directions for designing value propositions, and a dynamic system of capabilities for continually renewing customer experiences. The implementation of a customer data collection infrastructure, the adoption of an iterative and sequential innovation process, and the mobilization of cross-functional and multidisciplinary project teams, will help develop the firm’s dynamic system of capabilities.

Ythdf is a N6‐methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila

2021

Abstract N6‐methyladenosine (m6A) regulates a variety of physiological processes through modulation of RNA metabolism. This modification is particularly enriched in the nervous system of several species, and its dysregulation has been associated with neurodevelopmental defects and neural dysfunctions. In Drosophila, loss of m6A alters fly behavior, albeit the underlying molecular mechanism and the role of m6A during nervous system development have remained elusive. Here we find that impairment of the m6A pathway leads to axonal overgrowth and misguidance at larval neuromuscular junctions as well as in the adult mushroom bodies. We identify Ythdf as the main m6A reader in the nervous system,…