Search results for "aging"
showing 10 items of 10496 documents
Genetic effects on mobility, obesity and their association in older female twins
2009
Nowadays it is common that men and women gain weight during their adulthood, arriving to older ages with excessive body weight or obesity. This may potentially have adverse consequences on health in late life, as for example, it can lead to higher difficulties to move in everyday life and eventually to earlier disability. Many studies have shown that in older population obesity and mobility problems are hand-by-hand. The main aim of the present investigation was to elucidate the extent to which this relation between mobility and obesity could be explained by common genetic and environmental influences in older women.This research utilized data from 434 Finnish twin sisters gathered during t…
Le petit mangeur âgé : quand l'appétit fragilise le statut nutritionnel
2018
National audience; Le vieillissement est associé à de nombreux changements physiologiques, sensoriels, psychologiques et sociologiques susceptibles d'avoir un impact délétère sur la prise alimentaire de la personne âgée. Dans le cadre de RENESSENS, 68 personnes âgées vivant en institution (66 à 100 ans ; 87,4±0.9 d'âge moyen ; 75% de femmes) ont été recrutées et suivies pendant 24 heures de façon à peser tous les aliments et toutes les boissons consommées. Les résultats ont montré que 83% des résidents ne satisfaisaient pas à leurs besoins caloriques et protidiques (43% présentaient un apport inférieur au 2/3 des apports conseillés), essentiellement à cause d'une consommation insuffisante d…
Teacher experiences of supporting bilingual pupils and bilingual learning in Finnish and English mainstream school contexts
2017
Tämän tutkimuksen tarkoituksena on selvittää, miten sekä koulukieltä että oppilaiden ensikieliä huomioidaan ja tuetaan kouluissa. Tutkimuksessa keskitytään alakoulun opettajien kokemuksiin ilmiöstä. Koska käytänteet, jotka tukevat kielten rinnakkaista käyttöä (translanguagining) ovat keskeisiä kaksikielisen oppimisen toteuttamisessa yleisluokissa, tässä tutkimuksessa pyritään myös selvittämään opettajien näkemyksiä kaksikielisestä oppimisesta ja kielten rinnakkaisesta käytöstä koulussa. Tutkimus sijoittuu Suomen ja Englannin konteksteihin. Tutkimuksen tarkoituksena ei ole kuitenkaan tehdä vertailuja kahden maan välillä, vaan saada laajempi kuva ilmiöstä. Tutkimus on ajankohtainen, sillä mon…
Optimal Spectral Wavelengths for Discriminating Orchard Species Using Multivariate Statistical Techniques
2019
Sustainable management of orchard fields requires detailed information about the tree types, which is a main component of precision agriculture programs. To this end, hyperspectral imagery can play a major role in orchard tree species mapping. Efficient use of hyperspectral data in combination with field measurements requires the development of optimized band selection strategies to separate tree species. In this study, field spectroscopy (350 to 2500 nm) was performed through scanning 165 spectral leaf samples of dominant orchard tree species (almond, walnut, and grape) in Chaharmahal va Bakhtiyari province, Iran. Two multivariable methods were employed to identify the optimum wavelengths:…
The Effect of Organizational Politics on Job Stress; Mediating Role of Job Satisfaction
2018
The purpose of this quantitative study is to investigate the relationship between organizational politics and job stress and the mediating role of job satisfaction. Changes in working circumstances causes work related stress. There are various vulnerabilities associated to stress such as work content, workload, working hours, control and career development, position in the organization, interpersonal dealings and traditions of the employing organization.The job stress can be deterred through primary avoidance such as concentrated work design and administration growth, secondary avoidance such as workers' learning and training and tertiary avoidance such as mounting responsive organization s…
Exploration and exploitation : organization's age and the nature of its innovative behavior
2015
This study examines the relationship of an organization's age and its innovative activity. The innovative activity of an organization is discussed and examined through the concepts of exploration and exploitation, basing on the previous literature on organizational ambidexterity. Three hypotheses on the relationship of aging and the innovative behavior of an organization are formed based on the ambidexterity literature and the theories of the effect of aging on an organization. These hypotheses are tested with logistic regression analyses on a patent data set covering the modern biotechnology industry in Finland between 1973–2008. The results of the analyses show that age has a weak but sig…
Botulinum Toxin A for Oral Cavity Cancer Patients: In Microsurgical Patients BTX Injections in Major Salivary Glands Temporarily Reduce Salivary Prod…
2012
Abstract: In patients suffering from oral cavity cancer surgical treatment is complex because it is necessary to remove carcinoma and lymph node metastasis (through a radical unilateral or bilateral neck dissection) and to reconstruct the affected area by means of free flaps. The saliva stagnation in the post-operative period is a risk factor with regard to local complications. Minor complications related to saliva stagnation (such as tissue maceration and wound dehiscence) could become major complications compromising the surgery or the reconstructive outcome. In fact the formation of oro-cutaneous fistula may cause infection, failure of the free flap, or the patient’s death with carotid b…
Rescue of ovarian function: stem cells and regenerative factors
2022
El envejecimiento y otras condiciones de daño adquiridas, como los tratamientos oncológicos, conducen a un deterioro de la función ovárica. Sin embargo, incluso cuando los ovarios dañados pierden su capacidad de ovular, permanece un conjunto residual de folículos quiescentes que podrían ser rescatados y desarrollados en un nicho ovárico adecuado, dando lugar a ovocitos maduros. Los factores solubles secretados por las células madre podrían proporcionar un entorno ovárico adecuado para mantener y promover el crecimiento folicular. Por lo tanto, la presente tesis doctoral tuvo como objetivo evaluar los efectos regenerativos de diferentes fuentes de factores secretados por células madre en mod…
Oxysterols Incorporate in Primary Porcine Retinal Pigment Epithelial Cells and Induce Inflammation and Oxidative Stress
2006
International audience; Purpose: : Aging is associated with an accumulation of cholesterol in the Bruch’s membrane. Cholesterol is prone to undergo oxidation and to generate oxysterols that have cytotoxic properties. The aim of this study was to evaluate the effects of oxysterols on cell viability, oxidative stress and inflammation and to measure oxysterol incorporation in primary porcine retinal pigment epithelial (RPE) cell cultures. Methods: : Porcine RPE cells were incubated with oxysterols (24S–hydroxycholesterol, 24OH ; 25–hydroxycholesterol, 25OH and 7–ketocholesterol, 7K) (100µg, 50µM) for 24 and 48h. Cell viability was evaluated by measuring mitochondrial succinate dehydrogenase (S…
Increased dosage of Ink4/Arf protects against glucose intolerance and insulin resistance associated with aging
2013
Recent genome-wide association studies have linked type-2 diabetes mellitus to a genomic region in chromosome 9p21 near the Ink4/Arf locus, which encodes tumor suppressors that are up-regulated in a variety of mammalian organs during aging. However, it is unclear whether the susceptibility to type-2 diabetes is associated with altered expression of the Ink4/Arf locus. In the present study, we investigated the role of Ink4/Arf in age-dependent alterations of insulin and glucose homeostasis using Super-Ink4/Arf mice which bear an extra copy of the entire Ink4/Arf locus. We find that, in contrast to age-matched wild-type controls, Super-Ink4/Arf mice do not develop glucose intolerance with agi…