Search results for "aging"

Hormone replacement therapy enhances IGF-1 signaling in skeletal muscle by diminishing miR-182 and miR-233 expressions: A study on postmenopausal mon…

2014

MiRNAs are fine-tuning modifiers of skeletal muscle regulation, but knowledge of their hormonal control is lacking. We used a co-twin case–control study design, that is, monozygotic postmenopausal twin pairs discordant for estrogen-based hormone replacement therapy (HRT) to explore estrogen-dependent skeletal muscle regulation via miRNAs. MiRNA profiles were determined from vastus lateralis muscle of nine healthy 54–62- years-old monozygotic female twin pairs discordant for HRT (median 7 years). MCF-7 cells, human myoblast cultures and mouse muscle experiments were used to confirm estrogen’s causal role on the expression of specific miRNAs, their target mRNAs and proteins and finally the ac…

Antyoksydanty - przepis na długowieczność?

2016

Preliminary Study of the Mural Paintings of Sotterra Church in Paola (Cosenza, Italy)

2022

A multi-analytical approach was employed to study wall paintings located in the Sotterra church at Paola, in the province of Cosenza, Italy. The site is an underground church (hence the name of Sotterra, which means “under the earth”) rediscovered in the second half of the 19th century, during the building works of the Madonna del Carmine church on the same area. This underground church preserves valuable mural paintings having different styles. The construction’s dating and overlapped modifications made until the site was abandoned is also debated. A wall painting, depicting “The Virgin” as part of the “Annunciation and the Archangel Gabriel” prese…

Development and validation of an intrinsic capacity composite score in the Longitudinal Aging Study Amsterdam: a formative approach

2023

Abstract Background Intrinsic capacity (IC) defined by the WHO refers to the composite of five domains of capacities. So far, developing and validating a standardized overall score of the concept have been challenging partly because its conceptual framework has been unclear. We consider that a person’s IC is determined by its domain-specific indicators suggesting a formative measurement model. Aims To develop an IC score applying a formative approach and assess its validity. Methods The study sample (n = 1908) consisted of 57–88-year-old participants from the Longitudinal Aging Study Amsterdam (LASA). We used logistic regression models to select the indicators to the IC score with 6-year fu…

Ruolo dell’imaging funzionale nel management delle emorragie cerebrali atipiche: proposta di un protocollo diagnostico derivato dalla sperimentazione…

2005

2014

Morphogenesis in plants is usually reconstructed by scanning electron microscopy and histology of meristematic structures. These techniques are destructive and require many samples to obtain a consecutive series of states. Unfortunately, using this methodology the absolute timing of growth and complete relative initiation of organs remain obscure. To overcome this limitation, an in vivo observational method based on Epi-Illumination Light Microscopy (ELM) was developed and tested with a male inflorescence meristem (floral unit) of the handkerchief tree Davidia involucrata Baill. (Nyssaceae). We asked whether the most basal flowers of this floral unit arise in a basipetal sequence or, altern…

Neighborhood Mobility and Unmet Physical Activity Need in Old Age: A 2-Year Follow-Up

2020

Background: Many older people report a willingness to increase outdoor physical activity (PA), but no opportunities for it, a situation termed as unmet PA need. The authors studied whether lower neighborhood mobility and PA precede the development of unmet PA need. Methods: Community-dwelling 75- to 90-year-old people (n = 700) were interviewed annually for 2 years. Unmet PA need, neighborhood mobility, and PA were self-reported. In addition, accelerometer-based step counts were assessed among a subgroup (n = 156). Results: Logistic regression analyses revealed that lower baseline neighborhood mobility (odds ratio 3.02, 95% confidence interval [1.86, 4.90] vs. daily) and PA (odds ratio 4.37…

Physical disability in community-dwelling older people after hip fracture : randomized controlled trials with physical rehabilitation

2013

Mathematical Models and their Solutions for Domains of Compex Form

2014

Promocijas darbā tiek apskatīti dažādi oriģināli modeļi un to risinājumi sarežģītas formas apgabaliem. Intensīvās tērauda rūdīšanas procesi sistēmām ar ribām tiek aprakstīti ar 3D hiperbolisko, kā arī ar klasisko siltuma vadīšanas vienādojumu. Precīzā atrisinājuma iegūšanai izmantota Grīna funkciju metode un tās vispārinājums. Modernajos datoros sastopamajām sistēmām ar dubulsieniņu un dubultribu dota stacionārā un nestacionārā siltumvadīšanas problēma 2D gadījumā. Tās risinājums tiek iegūts ar konservatīvās viduvēšanas metodi, galīgo diferenču metodi un tās modifikāciju robežnosacījumiem. Piedāvāts jauns matemātiskais modelis vītola flautai, problēmas formulējumā izmantojot 1D lineāru viļņ…

Distributed $n$-player approachability and consensus in coalitional games

2015

We study a distributed allocation process where, at each time, every player: i) proposes a new bid based on the average utilities produced up to that time, ii) adjusts such allocations based on the inputs received from its neighbors, and iii) generates and allocates new utilities. The average allocations evolve according to a doubly (over time and space) averaging algorithm. We study conditions under which the average allocations reach consensus to any point within a predefined target set even in the presence of adversarial disturbances. Motivations arise in the context of coalitional games with transferable utilities (TU) where the target set is any set of allocations that makes the grand …