Search results for "alcoholic"
showing 10 items of 509 documents
NR1H4 rs35724 G>C variant modulates liver damage in nonalcoholic fatty liver disease
2021
Background and Aims: Farnesoid X receptor (FXR) plays a key role in bile acid and lipid homeostasis. Experimental evidence suggests that it can modulate liver damage related to nonalcoholic fatty liver disease (NAFLD). We examined the impact of the NR1H4 rs35724 G>C, encoding for FXR, on liver damage in a large cohort of patients at risk of steatohepatitis. Methods: We considered 2,660 consecutive individuals at risk of steatohepatitis with liver histology. The rs35724 G>C polymorphisms were genotyped by TaqMan assays. Gene expression was evaluated by RNASeq in a subset of patients (n = 124). Results: The NR1H4 rs35724 CC genotype, after adjusting for clinic-metabolic and genetic conf…
The Role of Transient Elastography in NAFLD
2021
On the ground of its rising prevalence, nonalcoholic fatty liver disease (NAFLD) is nowadays the most relevant liver disease worldwide, affecting about 25% of the general population [1].
Probiotics as a Dietary Intervention for Reducing the Risk of Nonalcoholic Fatty Liver Disease
2019
Nonalcoholic fatty liver disease (NAFLD) is characterized by an increase in triglyceride fat content of liver cells without excessive consumption of alcohol. It is the most predominant liver disease among different age groups including children and adults. Unhealthy foods such as high fructose and high trans-fatty acids in saturated fat seem to be associated with the pathogenesis of NAFLD. Different clusters of gut microbiota, e.g., Firmicutes, could regulate the energy balance and fat storage. Furthermore, different metabolites of gut microbiota, for example, endogenous short chain fatty acids and ethanol, are associated with increased levels of lipogenesis. Additionally, metabolism of end…
Mujeres con dependencia alcohólica: su participación en grupos de Alcohólicos Anónimos
2019
alcoholism, Alcoholics Anonymous, sexims, gender studies
Akūta alkohola hepatīta klīniskā norise un iznākumi
2015
Diplomdarba tēma. Akūta alkohola hepatīta klīniskā norise un iznākumi. Ievads. Alkohola hepatīts ir klīnisks sindroms, ko izraisa hroniska alkohola lietošana. Akūts alkohola hepatīts vienmēr attīstās uz jau esoša hroniska alkohola aknu bojājuma fona – taukainās hepatozes, steatohepatīta, fibrozes vai cirozes. Agrīna mirstība no alkohola hepatīta variē pēc slimības smaguma no 20% vieglām formām līdz 30-60% smagām formām. Darba mērķis. Pacientiem ar akūtu alkohola hepatītu noteikt un salīdzināt prognostiskos rādītājus pēc Maddrey un MELD aprēķiniem, kas ļautu prognozēt slimības attīstības tendenci un iznākumu pirmreizēji stacionētiem, atkārtoti stacionētiem un mirušiem pacientiem Latvijā. Mat…
Moral transgression, disease and holistic health in the Livingstonia Mission in late nineteenth and early twenttieth-century Malawi
2009
This article examines ideas of morality and health, and connections between moral transgression and disease in both Scottish missionary and Central African thought in the context of the Livingstonia Mission of the Presbyterian Free Church of Scotland in Malawi during the late nineteenth and early twentieth centuries.2 By concentrating on debates, conflicts and co-operation between missionaries and Africans over the key issues of beer drinking and sexual morality, this article explores the emergence of a new ‘moral hygiene’ among African Christian communities in Northern Malawi.<br><br>Este artículo analiza las ideas sobre moralidad y salud, así como las relaciones entre transgre…
Effect of Mastiha supplementation on NAFLD: The MAST4HEALTH Randomised, Controlled Trial
2021
On behalf of MAST4HEALTH consortium: et al.
Alcoholic Beverage and Meal Choices for the Prevention of Noncommunicable Diseases: A Randomized Nutrigenomic Trial
2018
Background. Noncommunicable diseases (NCDs) are the first cause of death worldwide. Mediterranean diet may play a crucial role in the prevention of NCDs, and the presence of wine in this diet could play a positive role on health. Methods. 54 healthy volunteers consumed one of the following beverages: red (RW) or white wine (WW), vodka (VDK), and/or Mediterranean meal (MeDM) and high-fat meal (HFM). Results. OxLDL-C changed significantly between baseline versus HFM, MeDM versus HFM, and HFM versus HFM + RW (p<0.05). Significant upregulation of catalase (CAT) was observed only after RW. Conversely, WW, VDK, RW + MeDM, HF + WW, and HF + VDK determined a significant downregulation of CAT gen…
IL-33/ST2 pathway regulates neutrophil migration and predicts outcome in patients with severe alcoholic hepatitis.
2020
Background & Aims Severe alcoholic hepatitis (SAH) is associated with a high risk of infection. The IL-33/ST2 pathway is involved in sepsis control but data regarding its role in alcohol-related liver disease (ALD) are lacking. We aimed to characterize the role of IL-33/ST2 in the polymorphonuclear neutrophils (PMNs) of patients with ALD and SAH. Methods Serum and circulating neutrophils were collected from patients with SAH, alcoholic cirrhosis and healthy controls. We quantified IL-33/ST2 pathway activity and CXCR2 at baseline and after exposure to IL-33. We also determined the migration capacity of PMNs. Results The decoy receptor of IL-33 (soluble ST2 [sST2]) was increased in SAH vs. ci…
Metabolic Inflammation-Associated IL-17A Causes Non-alcoholic Steatohepatitis and Hepatocellular Carcinoma
2016
Obesity increases hepatocellular carcinoma (HCC) risks via unknown mediators. We report that hepatic unconventional prefoldin RPB5 interactor (URI) couples nutrient surpluses to inflammation and non-alcoholic steatohepatitis (NASH), a common cause of HCC. URI-induced DNA damage in hepatocytes triggers inflammation via T helper 17 (Th17) lymphocytes and interleukin 17A (IL-17A). This induces white adipose tissue neutrophil infiltration mediating insulin resistance (IR) and fatty acid release, stored in liver as triglycerides, causing NASH. NASH and subsequently HCC are prevented by pharmacological suppression of Th17 cell differentiation, IL-17A blocking antibodies, and genetic ablation of t…