Search results for "alelos"

showing 4 items of 4 documents

SNPs in bone-related miRNAs are associated with the osteoporotic phenotype

2017

AbstractBiogenesis and function of microRNAs can be influenced by genetic variants in the pri-miRNA sequences leading to phenotypic variability. This study aims to identify single nucleotide polymorphisms (SNPs) affecting the expression levels of bone-related mature microRNAs and thus, triggering an osteoporotic phenotype. An association analysis of SNPs located in pri-miRNA sequences with bone mineral density (BMD) was performed in the OSTEOMED2 cohort (n = 2183). Functional studies were performed for assessing the role of BMD-associated miRNAs in bone cells. Two SNPs, rs6430498 in the miR-3679 and rs12512664 in the miR-4274, were significantly associated with femoral neck BMD. Further, we…

0301 basic medicineconformation:Diseases::Wounds and Injuries::Fractures Bone::Hip Fractures [Medical Subject Headings]:Phenomena and Processes::Genetic Phenomena::Phenotype [Medical Subject Headings]Polimorfismo de nucleótido simpleGene ExpressionboneOsteoblastosDensidad ósea:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Cohort StudiesGene Frequencysingle nucleotide polymorphismBone DensityBone cellOssosgeneticsFracturas osteoporóticasCells CulturedGeneticsBone mineralMicroARNsMultidisciplinarymicroRNAbiologyQalleleR:Diseases::Wounds and Injuries::Fractures Bone::Osteoporotic Fractures [Medical Subject Headings]clinical trialMiddle Agedcohort analysisPhenotypeHumanosFenotipmedicine.anatomical_structureCancellous BoneosteoblastMedicine:Diseases::Musculoskeletal Diseases::Bone Diseases [Medical Subject Headings]:Phenomena and Processes::Genetic Phenomena::Genotype [Medical Subject Headings]:Anatomy::Cells::Connective Tissue Cells::Osteoblasts [Medical Subject Headings]AlelosFenotipomusculoskeletal diseasesmedicine.medical_specialtyGenotypeScienceSingle-nucleotide polymorphismBiologychemistryPolymorphism Single NucleotideArticleBone and Bones:Anatomy::Musculoskeletal System::Skeleton::Bone and Bones::Cancellous Bone [Medical Subject Headings]03 medical and health sciencesCalcification PhysiologicInternal medicinemicroRNAmedicineHumanshumanproceduresAllele:Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Alleles [Medical Subject Headings]AllelesFemoral neckGenetic associationAgedcell culture:Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Bone Density [Medical Subject Headings]:Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism Genetic::Polymorphism Single Nucleotide [Medical Subject Headings]OsteoblastsEnfermedades óseasFracturas de caderaComputational BiologyCuello femoral:Chemicals and Drugs::Nucleic Acids Nucleotides and Nucleosides::Antisense Elements (Genetics)::RNA Antisense::MicroRNAs [Medical Subject Headings]MicroRNAs030104 developmental biologyEndocrinologymulticenter studybone mineralizationNucleic Acid ConformationOsteoporosispathology:Anatomy::Musculoskeletal System::Skeleton::Bone and Bones::Bones of Lower Extremity::Leg Bones::Femur::Femur Neck [Medical Subject Headings]TranscriptomemetabolismGenotipoFractures
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Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocar…

2014

[Background] The Fas apoptotic pathway has been implicated in type 2 diabetes and cardiovascular disease. Although a polymorphism (rs7138803; G > A) near the Fas apoptotic inhibitory molecule 2 (FAIM2) locus has been related to obesity, its association with other cardiovascular risk factors and disease remains uncertain.

MalealelosEndocrinology Diabetes and MetabolismhumanosLOCIMyocardial Infarctionproteínas reguladoras de la apoptosisApoptosisType 2 diabetesVARIANTSDiet Mediterraneanestudios de seguimientoCoronary artery diseaseClinical trialsRisk FactorsMyocardial infarctionLongitudinal Studiesmediana edadOriginal Investigationeducation.field_of_studyancianoDiabetisdietaHàbits alimentarisCAUSE MORTALITYDiabetesSOLUBLE FASMiddle Agedestudios de asociación genéticaMEDITERRANEAN DIETCARDIOVASCULAR-DISEASECORONARY-ARTERY-DISEASEObesitatFemaleCardiology and Cardiovascular Medicinemedicine.medical_specialtyFood habitsPopulationHeart rateproteínas de membranasMediterranean cookingDiabetes mellitusInternal medicineCuina mediterràniamedicineDiabetes MellitusHumansfactores de riesgoJAPANESE POPULATIONGenetic Predisposition to DiseaseObesityGENOME-WIDE ASSOCIATIONeducationobesidadAllelesGenetic Association Studiesinfarto de miocardioAgedPolymorphism Geneticbusiness.industryMembrane Proteinspredisposición genética a la enfermedadmedicine.diseaseObesityFAIM2DietBODY-MASS INDEXInfart de miocardiMyocardial infarctionEndocrinologyBlood pressureDiabetes Mellitus Type 2frecuencia cardíacaestudios longitudinalesbusinessApoptosis Regulatory ProteinsBody mass indexFollow-Up StudiesAssaigs clínics
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Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortal…

2016

Controversy persists on the association between dairy products, especially milk, and cardiovascular diseases (CVD). Genetic proxies may improve dairy intake estimations, and clarify diet-disease relationships through Mendelian randomization. We meta-analytically (n T (nonpersistence>persistence), dairy intake, and CVD biomarkers in American (Hispanics, African-American and Whites) and Mediterranean populations. Moreover, we analyzed longitudinal associations with milk, CVD and mortality in PREDIMED), a randomized Mediterranean diet (MedDiet) intervention trial (n = 7185). The MCM6-rs3754686/MCM6-rs309180 (as proxy), LP-allele (T) was strongly associated with higher milk intake, but inconsis…

MalealelosMediterranean dietMETABOLIC RISK-FACTORShumanosSINGLE-NUCLEOTIDE POLYMORPHISMComponente 6 del complejo de mantenimiento de minicromosomasDisease030204 cardiovascular system & hematologyMediterraneanAssociationsDiet MediterraneanMediterranean populationMCM6-rs37546860302 clinical medicineMedicineDisease030212 general & internal medicinemediana edadDAIRY CONSUMPTION2. Zero hungerancianoeducation.field_of_studyBioquímica y tecnologíaMultidisciplinarydietaMediterranean RegionHàbits alimentarisMendelian Randomization AnalysisMiddle AgedLlet3. Good healthBiochemistry and technologyBODY-WEIGHTCardiovascular diseasesMilkAmerican populationCardiovascular DiseasesMeta-analysisMarcadors bioquímicsFOOD-FREQUENCY QUESTIONNAIREFemaleLlet -- Aspectes nutricionalsGenetic MarkersFood habitsPopulationenfermedades cardiovascularesUNITED-STATESSistema cardiovascular malaltiesBioquímica i biotecnologiaArticleDIETleche03 medical and health sciencesSex Factors:Ciencias de la Salud::Medicina preventiva [Materias Investigacion]Sistema cardiovascular -- Malalties -- Aspectes genèticsEnvironmental healthMendelian randomizationMortalitatSNPAnimalsHumansPUERTO-RICANMortalityeducationMilk intakeLACTASE-PERSISTENCE PHENOTYPEAllelescardiovascular biomarkersAgedbusiness.industryMalalties cardiovascularsCardiovascular biomarkersmarcadores genéticosMendelian Randomization AnalysisMinichromosome Maintenance Complex Component 6United StatesDietBiotechnologyCardiovascular diseases (CVD)Lactase persistence2045-2322animalesanálisis de la aleatorización mendelianaDOSE-RESPONSE METAANALYSIS:Ciencias de la Salud::Endocrinología [Materias Investigacion]business
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La corrupción política y el principio de legalidad penal: incidencia en la esfera de derechos de los justiciables

2017

Uno de los términos más empleados para definir la desviación en el actuar de los poderes públicos es la corrupción. La legislación nacional se ha ocupado de desplegar textos normativos dirigidos a su lucha y punibilidad. No obstante, en el ámbito penal, que es donde cobra especial virtualidad dicho término, no hay un concepto jurídico que determine cuál es su concepto y contenido, ni existe una sistematización de los tipos penales que se consideran integrados en él. La omisión del legislador penal determina una afección al principio de legalidad penal y al principio de seguridad jurídica, en la medida que se irrogan al citado término unas consecuencias jurídicas, afección que se hace más gr…

derecho a la tutela judicial efectivajuicios paralelosUNESCO::CIENCIAS JURÍDICAS Y DERECHO
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