6533b82afe1ef96bd128cce2

RESEARCH PRODUCT

Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial

José LapetraMiquel FiolEmilio RosEnrique Gómez-graciaEnrique Gómez-graciaOscar ColtellOscar ColtellValentina Ruiz-gutiérrezValentina Ruiz-gutiérrezErnest VinyolesCarolina OrtegaCarolina OrtegaDolores CorellaDolores CorellaMontserrat FitóJose M. OrdovasJose M. OrdovasJose M. OrdovasRamon EstruchJosé I. GonzálezJosé I. GonzálezJosé V SorlíJosé V. SorlíCarmen SaizMiguel ÁNgel Martínez-gonzálezMiguel ÁNgel Martínez-gonzálezXavier PintóLluis Serra-majemLluis Serra-majemFernando ArósAmelia MartiAmelia MartiMònica Bulló

subject

MalealelosEndocrinology Diabetes and MetabolismhumanosLOCIMyocardial Infarctionproteínas reguladoras de la apoptosisApoptosisType 2 diabetesVARIANTSDiet Mediterraneanestudios de seguimientoCoronary artery diseaseClinical trialsRisk FactorsMyocardial infarctionLongitudinal Studiesmediana edadOriginal Investigationeducation.field_of_studyancianoDiabetisdietaHàbits alimentarisCAUSE MORTALITYDiabetesSOLUBLE FASMiddle Agedestudios de asociación genéticaMEDITERRANEAN DIETCARDIOVASCULAR-DISEASECORONARY-ARTERY-DISEASEObesitatFemaleCardiology and Cardiovascular Medicinemedicine.medical_specialtyFood habitsPopulationHeart rateproteínas de membranasMediterranean cookingDiabetes mellitusInternal medicineCuina mediterràniamedicineDiabetes MellitusHumansfactores de riesgoJAPANESE POPULATIONGenetic Predisposition to DiseaseObesityGENOME-WIDE ASSOCIATIONeducationobesidadAllelesGenetic Association Studiesinfarto de miocardioAgedPolymorphism Geneticbusiness.industryMembrane Proteinspredisposición genética a la enfermedadmedicine.diseaseObesityFAIM2DietBODY-MASS INDEXInfart de miocardiMyocardial infarctionEndocrinologyBlood pressureDiabetes Mellitus Type 2frecuencia cardíacaestudios longitudinalesbusinessApoptosis Regulatory ProteinsBody mass indexFollow-Up StudiesAssaigs clínics

description

[Background] The Fas apoptotic pathway has been implicated in type 2 diabetes and cardiovascular disease. Although a polymorphism (rs7138803; G > A) near the Fas apoptotic inhibitory molecule 2 (FAIM2) locus has been related to obesity, its association with other cardiovascular risk factors and disease remains uncertain.

yearjournalcountryeditionlanguage
2014-01-06
10.1186/1475-2840-13-5http://hdl.handle.net/2445/108628