Search results for "aloin"

Mucoadhesive Polymeric Films to Enhance Barbaloin Penetration Into Buccal Mucosa: a Novel Approach to Chemoprevention.

2018

Nowadays, chemoprevention by administering natural supplements is considered an attractive strategy to reverse, suppress, or prevent the evolution of premalignant oral lesions. In particular, Barbaloin exhibits anti-proliferative, anti-inflammatory, and anti-cancer properties, and it results useful in multi-therapy with classic chemotherapeutics. Therefore, in this work, mucoadhesive buccal films, as locoregional drug delivery system able to provide a targeted and efficient therapeutic delivery of Barbaloin, are proposed. Thus, Aloin extract-loaded Eudragit (R) RL100 or Eudragit (R) RS100-based buccal films were designed in order to obtain an easily self-administrable formulation capable of…

Increased illumination levels enhance biosynthesis of aloenin A and aloin B in Aloe arborescens Mill., but lower their per-plant yield

2021

Abstract Leaves of Aloe arborescens Mill. are a relevant source of secondary metabolites of pharmaceutical relevance. Notwithstanding, specialized cultivations of A. arborescens are still rather limited, and a straightforward agronomical research addressed to the obtainment of high-quality material is lacking. With the purpose to fill this gap, from 2016 to 2018, a trial was arranged to evaluate the growth and development of A. arborescens, along with the production of four active metabolites (aloin A and B, aloenin A, and isoaloeresin D) with varying some growth conditions. Two growth substrates (“A”- a commercial substrate, and “B”- the same substrate + 20 % perlite), two durations of pre…

New national and regional bryophyte records, 51

2017

1. Aloina rigida (Hedw.) Limpr.Contributors: O. Yu. Pisarenko, V. E. Fedosov and V. A. BakalinRussia: Primorsky Territory, Dalnegorsky District, vicinity of Dalnegorsk Town, NE-facing steep slope o...

Revisiting neutralization theory and its underlying assumptions to inspire future information security research

2022

Over two decades ago, neutralization theory was introduced to information systems research from the field of criminology and is currently emerging as an influential foundation to both explain and solve the information security policy noncompliance problem. Much of what we know about the theory focuses exclusively on the neutralization techniques identified in the original as well as subsequent criminological writings. What is often left unexamined in IS research is the underlying assumptions about the theory’s core elements; assumptions about the actor, the act, the normative system, and the nature of neutralizing itself. The objective of this commentary is to revisit the origin of neutrali…

Mukautuvat viipalointialgoritmit lisäävässä valmistuksessa

2017

Lisäävä valmistus on kasvattanut nopeasti suosiotaan viime vuosina. Viipalointi on oleellinen osa lisäävää valmistusta, mikä vaikuttaa esimerkiksi valmistettavan esineen pinnan laatuun, valmistusnopeuteen sekä mekaanisiin ominaisuuksiin. Tämän tutkielman tarkoituksena on selvittää, minkälaisia ominaisuuksia viipalointialgoritmilta vaaditaan ja minkälaisia menetelmiä niiden toteuttamiseen on olemassa. Mukautuvaa viipalointialgoritmia käyttämällä voidaan nopeuttaa esineen valmistusaikaa ilman, että pinnan laatu heikentyy. Additive manufacturing has rapidly gained popularity in recent years. Slicing is an important part of additive manufacturin processes. It affects the manufactured part’s sur…

Changes of species specific cuticular hydrocarbon profiles in the cockroaches Nauphoeta cinerea and Leucophaea maderae reared in heterospecific groups

1997

0013-8703 (Print) 1570-7458 (Online); The cuticular hydrocarbon profiles of the cockroaches Nauphoeta cinerea and Leucophaea maderae are species-specific when maintained in homospecific rearings. When individuals were reared in mixed species colonies, they initially remained in homospecific groups under different shelters. However, after 14 days they formed one heterospecific group with cuticular profiles showing characteristics of both species. When individuals were returned in monospecific rearings, their cuticular hydrocarbon profiles returned to species-specific ones within 3 weeks.

Effects of combined hormone replacement therapy or its effective agents on the IGF-1 pathway in skeletal muscle.

2010

Objectives To investigate the effects of combined hormone replacement therapy (HRT) and its effective agents on the IGF-1 signaling pathway. Design and methods To examine the effects of HRT on skeletal muscle in vivo, we utilized pre- and post-intervention samples from a randomized double blinded trial with 50–57-year-old women. The intervention included the year-long use of either HRT preparation (2 mg 17β-estradiol, E2; 1 mg norethisterone acetate, NETA, n = 10) or placebo (CO, n = 9). Microarray technology and quantitative PCR (qPCR) were used to study the expression of insulin-like growth factor I (IGF-1) and its splice variants as well as IGF-1 receptor, Akt1, mTOR, FOXO1, FOXO3, atrog…

Aloin loaded matrix tablets for topical treatment of oral cancer

2008

Dihydroisocoumarins, Naphthalenes, and Further Polyketides from Aloe vera and A. plicatilis: Isolation, Identification and Their 5-LOX/COX-1 Inhibiti…

2021

The present study aims at the isolation and identification of diverse phenolic polyketides from Aloe vera (L.) Burm.f. and Aloe plicatilis (L.) Miller and includes their 5-LOX/COX-1 inhibiting potency. After initial Sephadex-LH20 gel filtration and combined silica gel 60- and RP18-CC, three dihydroisocoumarins (nonaketides), four 5-methyl-8-C-glucosylchromones (heptaketides) from A. vera, and two hexaketide-naphthalenes from A. plicatilis have been isolated by means of HSCCC. The structures of all polyketides were elucidated by ESI-MS and 2D 1H/13C-NMR (HMQC, HMBC) techniques. The analytical/preparative separation of 3R-feralolide, 3′-O-β-d-glucopyranosyl- and the new 6-O-β-d-glucopyranosyl…

Umbilical cord blood transplantation from unrelated donors in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia

2014

Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; There are very few disease-specific studies focusing on outcomes of umbilical cord blood transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia. We report the outcome of 45 patients with Philadelphia chromosome-positive acute lymphoblastic leukemia who underwent myeloablative single unit cord blood transplantation from unrelated donors within the GETH/GITMO cooperative group. Conditioning regimens were based on combinations of thiotepa, busulfan, cyclophospamide or fludarabine, and antithymocyte globulin. At the time of transplantation, 35 patients (78%) were in first complete remission, four (8%) …