Search results for "alternative"

Flavonoids fromAlphitonia neocaledonica

1995

Flavonoids ofRhamnus lycioides; Part 2

1988

Nanoscale delivery of phytochemicals targeting CRISPR/Cas9 for cancer therapy.

2021

Abstract Background With growing global prevalence, cancer is a major cause of disease-related deaths. The understanding of the fundamental tumor pathology has contributed to the development of agents targeting oncogenic signaling pathways. Although these agents have increased survival for defined cancers, the therapeutic choices are still limited due to the development of drug resistance. CRISPR/Cas9 is a powerful new technology in cancer therapy by facilitating the identification of novel treatment targets and development of cell-based treatment strategies. Purpose We focused on applications of the CRISPR/Cas9 system in cancer therapy and discuss nanoscale delivery of cytotoxic phytochemi…

Shikonin reduces the tumour formation and IL-17 in a model of colorectal cancer associated to chronic colitis in C57BL/6 mice

2016

Artemisinin und seine Derivate – eine neue Option für die Krebstherapie?

2017

ZusammenfassungArtemisinin und seine Derivate sind nicht nur hochwirksame Medikamente gegen Malaria. Zahlreiche präklinische und vorläufige klinische Daten deuten darauf hin, dass sie auch therapeutisches Potenzial für die Onkologie besitzen könnten. Artemisinin-basierte Medikamente induzieren oxidativen Stress und DNA-Schäden und hemmen die Angiogenese. Tumorzellen sterben durch diese Substanzen, indem sie verschiedene Formen des Zelltodes hervorrufen (Apoptose, Autophagie, Ferroptose). Zytostatika-resistente Tumorzellen werden durch Artemisinin und seine Derivate effektiv abgetötet. Artemisinin-Derivate zeigen mit verschiedenen Standard-Krebsmedikamenten, Radiotherapie und therapeutischen…

Essential Oils of Chiliadenus Lopadusanus (Asteraceae)

2013

The essential oils from the leaves and flowers of Chiliadenus lopadusanus growing on Lampedusa Island were obtained by hydrodistillation and analyzed by GC-MS. The major component was camphor (39.4% in the leaves and 24.0% in the flowers), followed in the leaves by torreyol (6.7%), t-cadinol (5.2%) and 1,8-cineole (3.8%), while in the flowers by t-cadinol (15.2%), t-muurolol (5.1%) and torreyol (4.5%). Among the compounds identified, several seem to play a role in antibacterial, antifungal, allelopathic and spasmolytic activity. In addition, several compounds identified in this study seem to influence the attraction of Megachile ( Eutricharaea) apicalis (Megachilidae) and Halictus ( Selado…

Effects of Terpenoids from Salvia Willeana in Delayed-type Hypersensitivity, Human Lymphocyte Proliferation and Cytokine Production

2008

The effect of the lipophilic extract of S. willeana and three terpenoids isolated therefrom, camphor, lupeol and oleanolic acid, on oxazolone-induced hypersensitivity was evaluated. The extract reduced the ear edema by 46% at 24 h after challenge. All three terpenoids inhibited the edema and suppressed cytokines release at different rates. Lupeol inhibited the swelling by over 50% and reduced the production of IL-1β by 62%. Camphor caused inhibition of the efferent phase (45% inhibition at 72 h) and the levels of IL-1β, IL-4 and TNF-α (around 80% inhibition). Oleanolic acid diminished moderately the reaction and the levels of IL-4 and TNF-α. We also demonstrated that the three terpenoids i…

Investigation of the Alkaloid Content of Rauwolfia serpentina Roots from Regenerated Plants.

1991

The indole alkaloid content of RAUWOLFIA SERPENTINA roots from regenerated plants (from stem-and root-callus) was compared with the parental stock. Although the total alkaloid content seems to be slightly higher in the roots from regenerated plants, HPLC-analysis of individual alkaloids indicated that the contents of the alkaloids ajmaline ( 1), serpentine ( 2), and reserpine ( 3) are lower than in the roots of the parental stock. The glucoalkaloid raucaffricine ( 4) was identified as a constituent of all samples, thus providing the first evidence for its occurrence in roots of RAUWOLFIA SERPENTINA.

Ipobscurines, Non-ergoline Type Indole Compounds from the Seeds of Ipomoea obscura.

1986

Antiasthmatic effects of gamma linolenic acid -high dose Evening Primrose Oil and Borage Oil stimulate allergen tachyphylaxis of sensitized guinea pi…

2012

Summary Evening primose oil (EPO) and borage oil (BO), which contain high amounts of gamma linolenic acid (10% or 20%) and are described to stimulate prostaglandin E biosynthesis, were investigated in guinea pigs for their ability to stimulate an important active self protecting mechanism against allergens (“allergen tachyphylaxis”). Groups of 12 guinea pigs sensitized to ovalbumin were fed over five days with either EPO or BO (100mg/kg/day or 1 g/kg/day) prior to sequential allergen inhalation challenges (time 0′, 10′, 20′, 60′, 70′ and 80′). Bronchial obstruction was measured by whole body plethysmography. 100 mg/kg EPO did not alter the bronchial reactions of the animals; 100 mg and 1 g/…