Search results for "amer"
showing 10 items of 2105 documents
Health-related quality of life in Colombia: reference values of the EORTC QLQ-C30
2012
There are normative data of the quality of life (QoL) questionnaire EORTC QLQ-C30 (the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire) for several European countries and Korea, but not for Latin America. The aim of this study was to provide these normative values for the general population in Colombia and to assess differences in terms of age and sex. For that reason, a sample of 1500 representatively selected individuals of the Colombian population completed the EORTC QLQ-C30 form. Results showed that mean scores of the Colombian population are similar to those obtained in European countries; whereas the mean values from a Korean study were lower (…
Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, …
2019
ObjectiveTo assess the separate and combined associations of maternal pre‐pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact.DesignIndividual participant data meta‐analysis of 39 cohorts.SettingEurope, North America, and Oceania.Population265 270 births.MethodsInformation on maternal pre‐pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used.Main outcome measuresGestational hypertension, pre‐eclampsia, gestational diabetes, preterm birth, small and large for gestational age at birth.ResultsHigher maternal pre‐pregnancy BMI and gesta…
"Non giucando ... ma novellando": Primi appunti per una lettura comunitaria del Decameron
2015
Giovanni Boccaccio
Globalización y transnacionalidad: el papel de Europa en la proyección del cine latinoamericano actual
2016
International audience; Esta investigación se propone analizar el papel de Europa en la promoción del cine latinoamericano e indagar en cómo el nuevo escenario transnacional y los flujos de producción y distribución que este conlleva –que obedecen a lógicas dispares y a veces ambiguas–, repercute en las propuestas industriales y estéticas de la producción del subcontinente. Se debatirán conceptos como los de transnacionalidad, globalización o glocalización que acaparan muchos de los debates académicos actuales;La creciente globalización, a la que no es ajeno el cine, ha permitido en efecto la circulación de películas provenientes de países hasta entonces considerados periféricos. El cine la…
The GlpF residue Trp219 is part of an amino-acid cluster crucial for aquaglyceroporin oligomerization and function
2018
The vestibule loop regions of aquaglyceroporins are involved in accumulation of glycerol inside the channel pore. Even though most loop regions do not show high sequence similarity among aquaglyceroporins, loop E is highly conserved in aquaglyceroporins, but not in members of the homologous aquaporins. Specifically, a tryptophan residue is extremely conserved within this loop. We have investigated the role of this residue (Trp219) that deeply protrudes into the protein and potentially interacts with adjacent loops, using the E. coli aqualgyeroporin GlpF as a model. Replacement of Trp219 affects the activity of GlpF and impairs the stability of the tetrameric protein. Furthermore, we have id…
Cytotoxicity and chemosensitizing activity of amphiphilic poly(glycerol)-poly(alkylene oxide) block copolymers.
2014
All polymeric chemosensitizers proposed thus far have a linear poly(ethylene glycol) (PEG) hydrophilic block. To testify whether precisely this chemical structure and architecture of the hydrophilic block is a prerequisite for chemosensitization, we tested a series of novel block copolymers containing a hyperbranched polyglycerol segment as a hydrophilic block (PPO-NG copolymers) on multi-drug-resistant (MDR) tumor cells in culture. PPO-NG copolymers inhibited MDR of three cell lines, indicating that the linear PEG can be substituted for a hyperbranched polyglycerol block without loss of the polymers' chemosensitizing activity. The extent of MDR reversal increased with the polymers affinity…
Supramolecular functionalization and concomitant enhancement in properties of Au25 clusters
2014
We present a versatile approach for tuning the surface functionality of an atomically precise 25 atom gold cluster using specific host-guest interactions between ?-cyclodextrin (CD) and the ligand anchored on the cluster. The supramolecular interaction between the Au25 cluster protected by 4-(t-butyl)benzyl mercaptan, labeled Au25SBB18, and CD yielding Au25SBB18�?�CDn (n = 1, 2, 3, and 4) has been probed experimentally using various spectroscopic techniques and was further analyzed by density functional theory calculations and molecular modeling. The viability of our method in modifying the properties of differently functionalized Au25 clusters is demonstrated. Besides modifying their optoe…
Structures of collagen IV globular domains: insight into associated pathologies, folding and network assembly. Corrigendum
2020
The article by Casino et al. [IUCrJ (2018). 5, 765–779] is corrected.
MODELLI E STRUMENTI DI GOVERNANCE PUBBLICA DEL FENOMENO RELIGIOSO NEL SUBCONTINENTE AMERICANO
2020
Il lavoro analizza l’esperienza iberoamericana delle Comisiones o Comités de Libertad Religiosa, nonché degli altri strumenti similari di governance partecipativa, che si caratterizza per la varietà ed originalità della pertinente disciplina, nonché per l’influenza che essa è in grado di offrire alla circolazione giuridica di tale tipologia di organismi anche in contesti ordinamentali differenti.
Mechanisms of gustatory perception of dietary lipids : cross-talk with bitter taste and endocannabinoid receptors
2018
Obesity is one of the major public health problems at the beginning of the 21st century. Its prevalence is increasing steadily, especially among children. This observation is not insignificant because obesity is generally associated with various serious pathologies (type 2 diabetes, hypertension and cancer, etc.). Thus, investigations into the mechanisms involved in the taste perception of dietary lipids could shed light on their roles in the incidence of obesity.Several studies have demonstrated the role of endocannabinoids and bitter foods in obesity. Thus, we studied the cross-talk of cannabinoid receptors and bitter taste with lipid taste. This thesis has two components: cannabinoid rec…