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RESEARCH PRODUCT
Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts
Eleni PapadopoulouAndrea Von BergCamilla StoltenbergLuca RonfaniRomy GaillardMarie StandlMartine VrijheidSheila McdonaldYannis ManiosAnne M. KarvonenMarie-aline CharlesGeorge P. ChrousosDaniela PortaAnne-marie Nybo AndersenKeith M. GodfreyCarol Ní ChaoimhCostanza PizziMarleen M.h.j. Van GelderLawrence J. BeilinAna Cristina SantosCamilla Schmidt MorgenMonique MommersHazel InskipAlet H. WijgaPer MagnusMarie-france HivertNel RoeleveldLenie Van RossemTanja G. M. VrijkotteBarbara HeudeJane WestSteve TurnerMyriam DoyonThorkild I. A. SørensenAdriëtte J J M OostvogelsCarel ThijsErik MelénMerete EggesbøMaties TorrentIrina LehmannDavide GoriSusana SantosEmily OkenBerthold KoletzkoEllis VoermanJohn WrightAgnieszka PacPilar AmianoSarah CrozierJohn MeheganHein StigumLouise C. KennyVincent W. V. JaddoeVincent W. V. JaddoeDeirdre M. MurrayDebbie A LawlorFrancesco ForastiereJohanna MäkeläLorenzo RichiardiAnna BergströmFionnuala M. McauliffeElisabeth ThieringNathalie CostetHanna LagströmJuha PekkanenSheryl L. Rifas-shimanGeorge MoschonisRenata MajewskaKinga PolańskaRae-chi HuangGraham DevereuxVeit GroteLeanne K. KüpersIrva Hertz-picciottoEva CorpeleijnEllen A. NohrLeda ChatziOlga CostaOleksandr ZvinchukSara FarchiCécile ChevrierVagelis GeorgiuTomas TrnovecHenrique BarrosMaria Pia FantiniSuzanne ToughWojciech HankeDaniel O. Hryhorczuksubject
Gestational hypertensionand promotion of well-beingNutrition and DiseaseBirthweightReproductive health and childbirthLow Birth Weight and Health of the NewbornCardiovascularMedical and Health SciencesDISEASECohort Studies0302 clinical medicine3123 Gynaecology and paediatricsRisk FactorsPregnancyVoeding en ZiekteInfant MortalityOdds RatioMedicineBirth Weight2.1 Biological and endogenous factorsEPIDEMIOLOGYwq_200Aetiology2. Zero hungerPediatricRISKeducation.field_of_studyOUTCOMES030219 obstetrics & reproductive medicineObstetricspregnancy complicationsDiabetesObstetrics and GynecologyGestational ageweight gainASSOCIATIONGestational Weight GainGestational diabetesEuropeBirthweight ; Body Mass Index ; Pregnancy Complications ; Preterm Birth ; Weight GainOBESITYFemalemedicine.symptomAdultmedicine.medical_specialtyPRETERM BIRTHBirth weightPopulationGestational Agebody mass index[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetricswa_310Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18]03 medical and health sciencesAll institutes and research themes of the Radboud University Medical CenterPretermClinical ResearchHumanswq_100ObesityeducationObstetrics & Reproductive MedicineMetabolic and endocrineNutritionPregnancybusiness.industryContraception/ReproductionPreventionBirthweight; body mass index; pregnancy complications; preterm birth; weight gainAustraliaInfantbirth weightpreterm birthDIABETES-MELLITUSPreterm birth weight gainOverweightPerinatal Period - Conditions Originating in Perinatal Periodmedicine.diseaseNewbornPrevention of disease and conditionsReconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10]Good Health and Well BeingNorth America3.1 Primary prevention interventions to modify behaviours or promote wellbeingpregnancy complicationbusinessWeight gainBody mass indexwb_200description
ObjectiveTo assess the separate and combined associations of maternal pre‐pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact.DesignIndividual participant data meta‐analysis of 39 cohorts.SettingEurope, North America, and Oceania.Population265 270 births.MethodsInformation on maternal pre‐pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used.Main outcome measuresGestational hypertension, pre‐eclampsia, gestational diabetes, preterm birth, small and large for gestational age at birth.ResultsHigher maternal pre‐pregnancy BMI and gestational weight gain were, across their full ranges, associated with higher risks of gestational hypertensive disorders, gestational diabetes, and large for gestational age at birth. Preterm birth risk was higher at lower and higher BMI and weight gain. Compared with normal weight mothers with medium gestational weight gain, obese mothers with high gestational weight gain had the highest risk of any pregnancy complication (odds ratio 2.51, 95% CI 2.31– 2.74). We estimated that 23.9% of any pregnancy complication was attributable to maternal overweight/obesity and 31.6% of large for gestational age infants was attributable to excessive gestational weight gain.ConclusionsMaternal pre‐pregnancy BMI and gestational weight gain are, across their full ranges, associated with risks of pregnancy complications. Obese mothers with high gestational weight gain are at the highest risk of pregnancy complications. Promoting a healthy pre‐pregnancy BMI and gestational weight gain may reduce the burden of pregnancy complications and ultimately the risk of maternal and neonatal morbidity.Tweetable abstractPromoting a healthy body mass index and gestational weight gain might reduce the population burden of pregnancy complications.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-07-01 |