0000000000072298
AUTHOR
Barbara Heude
showing 19 related works from this author
Urban environment during early-life and blood pressure in young children
2021
Background: The urban environment is characterised by many exposures that may influence hypertension development from early life onwards, but there is no systematic evaluation of their impact on child blood pressure (BP). Methods: Systolic and diastolic blood pressure were measured in 4,279 children aged 4-5 years from a multi-centre European cohort (France, Greece, Spain, and UK). Urban environment exposures were estimated during pregnancy and childhood, including air pollution, built environment, natural spaces, traffic, noise, meteorology, and socioeconomic deprivation index. Single- and multiple-exposure linear regression models and a cluster analysis were carried out. Results: In multi…
Association of Gestational Weight Gain With Adverse Maternal and Infant Outcomes
2019
Importance: Both low and high gestational weight gain have been associated with adverse maternal and infant outcomes, but optimal gestational weight gain remains uncertain and not well defined for all prepregnancy weight ranges. Objectives: To examine the association of ranges of gestational weight gain with risk of adverse maternal and infant outcomes and estimate optimal gestational weight gain ranges across prepregnancy body mass index categories. Design, setting, and participants: Individual participant-level meta-analysis using data from 196 670 participants within 25 cohort studies from Europe and North America (main study sample). Optimal gestational weight gain ranges were estimated…
Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth.
2021
We would like to thank all the families that participated in these studies for their generous contribution. Detailed acknowledgements and funding can be found in Sup plementary Material.
Air Pollution Exposure During Pregnancy and Symptoms of Attention Deficit and Hyperactivity Disorder in Children in Europe
2018
Background: Exposure to air pollution during pregnancy may increase attention-deficit/hyperactivity disorder (ADHD) symptoms in children, but findings have been inconsistent. We aimed to study this association in a collaborative study of eight European population-based birth/child cohorts, including 29,127 mother-child pairs. Methods: Air pollution concentrations (nitrogen dioxide [NO2] and particulate matter [PM]) were estimated at the birth address by land-use regression models based on monitoring campaigns performed between 2008 and 2011. We extrapolated concentrations back in time to exact pregnancy periods. Teachers or parents assessed ADHD symptoms at 3-10 years of age. We classified …
Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
2020
The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located nearNEDD4LandSLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 d…
Déterminants précoces de l’appréciation et de la consommation d’aliments riches en protéines animales ou végétales à 5 ans
2017
Introduction et but de l’etude La consommation de proteines d’origine animale ou vegetale est devenue un element critique en termes de sante comme d’environnement. Dans ce contexte, il semble important de comprendre les facteurs precoces associes a l’appreciation et a la consommation d’aliments riches en proteines animales ou vegetales chez l’enfant. Materiel et methodes Lors du suivi a 5 ans, 1069 enfants de la cohorte mere–enfant Eden ont realise un test d’appreciation hedonique pour 36 aliments, tandis que leurs parents remplissaient un frequentiel de consommation, concernant leur enfant, pour 27 aliments. L’appreciation des aliments riches en proteines animales a ete estimee en faisant …
Urban environment during early-life and blood pressure in children
2020
Background. The urban environment is characterised by many exposures that may influence hypertension development, but studies evaluating multiple urban exposures from pregnancy onwards are lacking....
Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, …
2019
ObjectiveTo assess the separate and combined associations of maternal pre‐pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact.DesignIndividual participant data meta‐analysis of 39 cohorts.SettingEurope, North America, and Oceania.Population265 270 births.MethodsInformation on maternal pre‐pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used.Main outcome measuresGestational hypertension, pre‐eclampsia, gestational diabetes, preterm birth, small and large for gestational age at birth.ResultsHigher maternal pre‐pregnancy BMI and gesta…
Changes in parental smoking during pregnancy and risks of adverse birth outcomes and childhood overweight in Europe and North America
2020
Background Fetal smoke exposure is a common and key avoidable risk factor for birth complications and seems to influence later risk of overweight. It is unclear whether this increased risk is also present if mothers smoke during the first trimester only or reduce the number of cigarettes during pregnancy, or when only fathers smoke. We aimed to assess the associations of parental smoking during pregnancy, specifically of quitting or reducing smoking and maternal and paternal smoking combined, with preterm birth, small size for gestational age, and childhood overweight. Methods and findings We performed an individual participant data meta-analysis among 229,158 families from 28 pregnancy/bir…
Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: An individual participant data meta-analy…
2019
Background Maternal obesity and excessive gestational weight gain may have persistent effects on offspring fat development. However, it remains unclear whether these effects differ by severity of obesity, and whether these effects are restricted to the extremes of maternal body mass index (BMI) and gestational weight gain. We aimed to assess the separate and combined associations of maternal BMI and gestational weight gain with the risk of overweight/obesity throughout childhood, and their population impact. Methods and findings We conducted an individual participant data meta-analysis of data from 162,129 mothers and their children from 37 pregnancy and birth cohort studies from Europe, No…
Débuter la diversification alimentaire : une décision influencée par la croissance de l'enfant ?
2019
National audience; Les pratiques d'alimentation des nourrissons sont soumises à des influences multiples. Ainsi, l'âge de début de diversification varie selon de nombreux facteurs comme les caractéristiques maternelles (tabagisme, âge, niveau d'études, corpulence, pays de naissance) ou infantiles (sexe) (Bournez et al., 2017). Nous voulions étudier si cet âge pouvait de plus dépendre de la croissance de l'enfant, et traduire ainsi une sensibilité de la mère à cet aspect du développement. Nous avons envisagé que les enfants les plus grands (ou lourds, ou corpulents) pourraient être diversifiés plus tôt que les enfants de taille « moyenne ». Les données de la cohorte ELFE (Etude Longitudinale…
Supplementary data to: Algorithms to define abnormal growth in children: external validation and head-to-head 3 comparison 4 5
2018
Suplemental Tables 1, 2 and 3. Supplemental Fig.1 and Fig.2 Article published in J Clin Endocrinol Metab. 2018 Aug 20. doi: 10.1210/jc.2018-00723
Infant feeding practices and early growth among children of the nationwide Elfe cohort
2020
International audience; Rapid early growth is considered as a risk factor for obesity later in life. Breastfeeding is associated with slower growth in the first months of life, but the complementary diet of non- exclusively breastfed infants remains poorly considered. Our objective was to analyze the links between infant diet during the first year and growth up to 18 months. Analyses included 8315 infants from the Elfe birth cohort. Infants were grouped into clusters using hierarchical clustering according to infant diet characteristics (breastfeeding duration, introduction of infant formula, main food groups and unmixed foods). Association between clusters and weight, height and BMI betwee…
Déterminants précoces des préférences pour les sources de protéines animales ou végétales dans la cohorte mère-enfant EDEN
2016
Déterminants précoces des préférences pour les sources de protéines animales ou végétales dans la cohorte mère-enfant EDEN. Société francaise de pédiatrie
Déterminants précoces de l'appréciation et de la consommation d'aliments riches en protéines animales/végétales à 5 ans
2016
Introduction et but de l'étude :La consommation de protéines d'origine animale ou végétale est devenue un élément critique en termes de santé comme d'environnement. Dans ce contexte, il semble important de comprendre les facteurs précoces associés à l'appréciation et à la consommation d'aliments riches en protéines animales ou végétales chez l'enfant.Matériel et méthodes :Lors du suivi à 5 ans, 1069 enfants de la cohorte mère-enfant EDEN ont réalisé un test d'appréciation hédonique pour 36 aliments, tandis que leurs parents remplissaient un fréquentiel de consommation, concernant leur enfant, pour 27 aliments. L'appréciation des aliments riches en protéines animales a été estimée en faisant…
Consommation d’aliments issus de l’agriculture biologique pendant la diversification alimentaire et croissance jusqu’à 21 mois dans l’étude ELFE
2020
Introduction et but de l’étude : La consommation d’aliments issus de l’agriculture biologique (AB) été associée chez l’adulte à un moindre risque de surpoids ou d’obésité, indépendamment des facteurs associés. Aucune étude n’ayant été menée sur ces associations chez le jeune enfant, l’objectif de ce travail était d’analyser le lien entre la consommation d’aliments AB pendant la diversification alimentaire et la croissance des enfants jusqu’à 2 ans. Étant donnée la règlementation sur les aliments préparés destinés aux <3 ans, la consommation d’aliments AB à cette période de la vie aura vraisemblablement un impact différent chez les consommateurs d’aliments infantiles et chez les non consomma…
Air Pollution During Pregnancy and Childhood Cognitive and Psychomotor Development: Six European Birth Cohorts
2014
Background: Accumulating evidence from laboratory animal and human studies suggests that air pollution exposure during pregnancy affects cognitive and psychomotor development in childhood. Methods: We analyzed data from 6 European population-based birth cohorts-GENERATI ON R (The Netherlands), DUISBURG (Germany), EDEN (France), GASPII (Italy), RHEA (Greece), and INMA (Spain)-that recruited mother-infant pairs from 1997 to 2008. Air pollution levels-nitrogen oxides (NO2, NOx) in all regions and particulate matter (PM) with diameters of <2.5, <10, and 2.5-10 mu m (PM2.5, PM10, and PMcoarse, respectively) and PM2.5 absorbance in a subgroup-at birth addresses were estimated by land-use regressi…
Fish Intake in Pregnancy and Child Growth: A Pooled Analysis of 15 European and US Birth Cohorts
2016
Importance Maternal fish intake in pregnancy has been shown to influence fetal growth. The extent to which fish intake affects childhood growth and obesity remains unclear. Objective To examine whether fish intake in pregnancy is associated with offspring growth and the risk of childhood overweight and obesity. Design, Setting, and Participants Multicenter, population-based birth cohort study of singleton deliveries from 1996 to 2011 in Belgium, France, Greece, Ireland, Italy, the Netherlands, Norway, Poland, Portugal, Spain, and Massachusetts. A total of 26 184 pregnant women and their children were followed up at 2-year intervals until the age of 6 years. Exposures Consumption of fish dur…
Initiating complementary feeding: a decision influenced by the child's growth?
2020
International audience; Background and aims: Infant feeding practices are subject to multiple influences. The age of onset of complementary feeding (CF) varies according to many factors such as maternal characteristics (smoking, age, education level, body size, country of birth) or infant characteristics (sex) (Bournez et al., 2017). The aim was to study if, in addition to these factors, age could depend on the child's growth. We have hypothesized that larger children (or heavier / more corpulent ones) would be introduced to CF earlier than "average"-sized children would. Methods: Data from the ELFE cohort (French Longitudinal Study since Childhood) made it possible to describe the age of C…