0000000000115871

AUTHOR

Olga Costa

showing 11 related works from this author

Prenatal Exposure to NO2 and Ultrasound Measures of Fetal Growth in the Spanish INMA Cohort

2016

This study was funded by grants from the European Union: NEWGENERIS FP6-2003- Food-3-A-016320, FP7-ENV-2011 cod 282957, HEALTH.2010.2.4.5-1; and by grants from Spain: Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0031, and FIS-FEDER PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI04/2018, PI04/1436, PI05/1079, PI05/1052, PI06/1213, PI07/0314, PI08/1151, PI09/02647, PI09/02311, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI13/02429, PI14/0891, PI14/1687, and Miguel Servet CP11/00178 and MS13/00054), Conselleria de Sanitat Generalitat Valenciana, Generalitat de Catalunya (CIRIT 1999SGR 00241), Diputación Foral de Guipúzcoa (DFG/004), Departamento de Sanidad y Consumo Gobierno Vasc…

AdultMalemedicine.medical_specialtyAdolescentHealth Toxicology and MutagenesisNitrogen DioxideEmbaràsMEDLINE010501 environmental sciences01 natural sciencesUltrasonography PrenatalCohort StudiesFetal DevelopmentYoung Adult03 medical and health sciences0302 clinical medicinePregnancyFetal growthHumansMedicine030212 general & internal medicineYoung adult0105 earth and related environmental sciencesAir PollutantsPregnancyAnthropometrybusiness.industryObstetricsAire -- ContaminacióUltrasoundPublic Health Environmental and Occupational HealthAnthropometrymedicine.disease3. Good healthMaternal ExposureSpainChildren's Healthembryonic structuresCohortFemalebusinessCohort study
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Prenatal Exposure to Polybrominated Flame Retardants and Fetal Growth in the INMA Cohort (Spain)

2015

Our aim was to investigate the relation between PBDEs and fetal growth or newborn anthropometry in a Spanish cohort (2003-2008). PBDE congeners (BDE-47, -99, -153, -154, and -209) were determined in serum of 670 mothers at gestational week 12 and in 534 umbilical cord samples. Abdominal circumference (AC), estimated fetal weight (EFW), femur length (FL), and biparietal diameter (BPD) during gestation were measured by ultrasounds. At birth, weight (BW), head circumference (HC), and length (BL) were also measured. We assessed growth in the intervals between 12-20 and 20-34 weeks of gestation and size at birth by standard deviation (SD)-scores adjusted for constitutional characteristics. We co…

Adultmedicine.medical_specialtyFetal monitoring010501 environmental sciences01 natural sciencesUmbilical cordFlame retardantsArticleUltrasonography PrenatalCohort StudiesFetal Development03 medical and health sciences0302 clinical medicinePregnancyBayesian multivariate linear regressionInternal medicinePrenatal exposureHalogenated Diphenyl EthersmedicineFetal growthBody SizeHumansEnvironmental ChemistryPregnancy exposome030212 general & internal medicine0105 earth and related environmental sciencesPregnancyObstetricsbusiness.industryBody WeightInfant NewbornGeneral ChemistryAnthropometrymedicine.disease3. Good healthEndocrinologymedicine.anatomical_structureSpainPrenatal Exposure Delayed EffectsCohortGestationFemalebusinessCohort study
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Prenatal exposure to perfluoroalkyl substances and birth outcomes in a Spanish birth cohort

2017

BACKGROUND: Prenatal perfluorooctanoate (PFOA) exposure has been associated with reduced birth weight but maternal glomerular filtration rate (GFR) may attenuate this association. Further, this association remains unclear for other perfluoroalkyl substances (PFAS), such as perfluorooctane sulfonate (PFOS), perfluorohexane sulfonate (PFHxS), and perfluorononanoate (PFNA). We estimated associations between prenatal PFAS exposure and birth outcomes, and the influence of GFR, in a Spanish birth cohort. METHODS: We measured PFHxS, PFOS, PFOA, and PFNA in 1st-trimester maternal plasma (years: 2003-2008) in 1202 mother-child pairs. Continuous birth outcomes included standardized weight, length, he…

MaleEmbaràsFetal growth010501 environmental sciences01 natural sciencesToxicologychemistry.chemical_compound0302 clinical medicinePregnancyContaminantsBirth Weight030212 general & internal medicinelcsh:Environmental sciencesGeneral Environmental Sciencelcsh:GE1-350FluorocarbonsFluorocarbursObstetricsPregnancy OutcomeGestational ageHispanic or Latino3. Good healthAlkanesulfonic AcidsPerfluorooctanoate (PFOA)Àcids alcanoicsPrenatal Exposure Delayed EffectsEnvironmental PollutantsFemalePerfluorooctane sulfonate (PFOS)Glomerular filtration ratemedicine.symptomCaprylatesBirth cohortAdultmedicine.medical_specialtyBirth weightRenal functionGestational AgeINMA birth cohort03 medical and health sciencesmedicineHumans0105 earth and related environmental sciencesPregnancyInfant Newbornmedicine.diseasePerfluorooctaneLow birth weightPerfluoroalkyl substanceschemistryMother-child pairsParity (mathematics)
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Early Life Exposure to Perfluoroalkyl Substances (PFAS) and ADHD: A Meta-Analysis of Nine European Population-Based Studies

2020

Introduction: To date, the evidence for an association between perfluoroalkyl substances (PFAS) exposure and attention deficit and hyperactivity disorder (ADHD) is inconclusive. Objective: We investigated the association between early life exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), and ADHD in a collaborative study including nine European population-based studies, encompassing 4,826 mother-child pairs. Methods: Concentrations of PFOS and PFOA were measured in maternal serum/plasma during pregnancy, or in breast milk, with different timing of sample collection in each cohort. We used a validated pharmacokinetic model of pregnancy and lactation to estimate…

MaleHealth Toxicology and MutagenesisReproductive health and childbirth010501 environmental sciencesToxicology01 natural sciencesMedical and Health SciencesCohort Studies0302 clinical medicinePregnancyMedicine2.2 Factors relating to the physical environment030212 general & internal medicineAetiologyChildPediatricFluorocarbonsEarly life3. Good healthPeer reviewMilkBreast FeedingMental HealthAlkanesulfonic AcidsMeta-analysisChild PreschoolPrenatal Exposure Delayed EffectsEnvironmental PollutantsFemaleCaprylatesHumanPopulationMEDLINEMothers03 medical and health sciencesEnvironmental healthmental disordersHumansPreschool0105 earth and related environmental sciencesMilk Humanbusiness.industryResearchPublic Health Environmental and Occupational HealthEuropean populationEnvironmental Exposurebiochemical phenomena metabolism and nutritionAttention Deficit Hyperactivity Disorder (ADHD)Attention Deficit Disorder with HyperactivityAttention deficitbusinessEnvironmental SciencesEnvironmental Health Perspectives
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Perfluoroalkyl substances and immune cell counts in adults from the Mid-Ohio Valley (USA)

2021

Highlights • The literature on PFASs and circulating levels of immune cells is scarce. • Study of the association between PFASs and white blood cells at two different time points. • Cross-sectional study on the association between PFASs and lymphocyte subsets. • Positive association between PFHxS and total lymphocytes, especially for cell count. • Positive, but less consistent, association between PFOA and PFOS and total lymphocytes.

AdultSerum010504 meteorology & atmospheric sciencesWater contaminationCellPhysiologyCell Count010501 environmental sciencesBiology01 natural sciencesArticlePerfluorononanoic acidchemistry.chemical_compoundImmune systemPFASsInterquartile rangeWhite blood cellmedicineHumansGE1-350LymphocytesOhio0105 earth and related environmental sciencesGeneral Environmental ScienceFluorocarbonsEnvironmental sciencesPerfluorooctaneImmune systemmedicine.anatomical_structureAlkanesulfonic AcidschemistryWhite blood cellsPerfluorooctanoic acidEnvironmental PollutantsCaprylatesEnvironment International
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Organochlorine Compounds and Ultrasound Measurements of Fetal Growth in the INMA Cohort (Spain)

2014

This study was funded by grants from the EU (European Union): NEWGENERIS FP6-2003- Food-3-A-016320, FP7-ENV-2011 cod 282957, HEALTH.2010.2.4.5-1; and by grants from Spain: Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0031, and FIS-FEDER PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI04/2018, PI04/1436, PI05/1079, PI05/1052, PI06/1213, PI07/0314, PI08/1151, PI09/02647, PI09/02311, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI13/02429, PI14/0891, PI14/1687, and Miguel Servet CP11/00178 and CP13/00054), Conselleria de Sanitat Generalitat Valenciana, Generalitat de Catalunya (CIRIT 1999SGR 00241), Diputación Foral de Guipúzcoa (DFG/004), Departamento de Sanidad y Consumo Gobierno…

Adultmedicine.medical_specialtyHealth Toxicology and MutagenesisPhysiologyUltrasonography PrenatalFetal Developmentchemistry.chemical_compoundPregnancyInternal medicinemedicineHydrocarbons ChlorinatedHumansFetusPregnancybusiness.industryUltrasoundPublic Health Environmental and Occupational HealthPolychlorinated biphenylHexachlorobenzeneAnthropometrymedicine.disease3. Good healthEndocrinologychemistryMaternal ExposureSpainCohortChildren's HealthGestationFemalebusiness
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Prenatal perfluoroalkyl substance exposure and neuropsychological development throughout childhood: The INMA Project.

2021

Abstract Background Perfluoroalkyl substances (PFASs) have been related to neurodevelopmental toxicity in animals. However, human studies are inconclusive. Objectives To evaluate the association between prenatal PFAS exposure and neuropsychological development during childhood. Methods 1240 mother–child pairs from the Spanish INMA Project were analyzed. Perfluorohexanesulfonic acid (PFHxS), perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), and perfluorononanoic acid (PFNA) were measured in first-trimester maternal plasma. Neuropsychological development was assessed at 14 months, 4–5 and 7 years covering four domains: general cognitive, general motor, attention, and working me…

MaleEnvironmental EngineeringHealth Toxicology and Mutagenesis0211 other engineering and technologies02 engineering and technology010501 environmental sciences01 natural sciencesPerfluorononanoic acidchemistry.chemical_compoundPregnancyEnvironmental healthEnvironmental ChemistryMedicineHumansChildWaste Management and DisposalPrenatal exposure0105 earth and related environmental sciences021110 strategic defence & security studiesFluorocarbonsHuman studiesbusiness.industryNeuropsychologyPollutionPerfluorohexanesulfonic acidPerfluorooctanePregnancy Trimester FirstchemistryAlkanesulfonic AcidsPerfluorooctanoic acidEnvironmental PollutantsFemaleCaprylatesSulfonic AcidsbusinessJournal of hazardous materials
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Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, …

2019

ObjectiveTo assess the separate and combined associations of maternal pre‐pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact.DesignIndividual participant data meta‐analysis of 39 cohorts.SettingEurope, North America, and Oceania.Population265 270 births.MethodsInformation on maternal pre‐pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used.Main outcome measuresGestational hypertension, pre‐eclampsia, gestational diabetes, preterm birth, small and large for gestational age at birth.ResultsHigher maternal pre‐pregnancy BMI and gesta…

Gestational hypertensionand promotion of well-beingNutrition and DiseaseBirthweightReproductive health and childbirthLow Birth Weight and Health of the NewbornCardiovascularMedical and Health SciencesDISEASECohort Studies0302 clinical medicine3123 Gynaecology and paediatricsRisk FactorsPregnancyVoeding en ZiekteInfant MortalityOdds RatioMedicineBirth Weight2.1 Biological and endogenous factorsEPIDEMIOLOGYwq_200Aetiology2. Zero hungerPediatricRISKeducation.field_of_studyOUTCOMES030219 obstetrics & reproductive medicineObstetricspregnancy complicationsDiabetesObstetrics and GynecologyGestational ageweight gainASSOCIATIONGestational Weight GainGestational diabetesEuropeBirthweight ; Body Mass Index ; Pregnancy Complications ; Preterm Birth ; Weight GainOBESITYFemalemedicine.symptomAdultmedicine.medical_specialtyPRETERM BIRTHBirth weightPopulationGestational Agebody mass index[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetricswa_310Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18]03 medical and health sciencesAll institutes and research themes of the Radboud University Medical CenterPretermClinical ResearchHumanswq_100ObesityeducationObstetrics & Reproductive MedicineMetabolic and endocrineNutritionPregnancybusiness.industryContraception/ReproductionPreventionBirthweight; body mass index; pregnancy complications; preterm birth; weight gainAustraliaInfantbirth weightpreterm birthDIABETES-MELLITUSPreterm birth weight gainOverweightPerinatal Period - Conditions Originating in Perinatal Periodmedicine.diseaseNewbornPrevention of disease and conditionsReconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10]Good Health and Well BeingNorth America3.1 Primary prevention interventions to modify behaviours or promote wellbeingpregnancy complicationbusinessWeight gainBody mass indexwb_200
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Dietary and Household Sources of Prenatal Exposure to Polybrominated Diphenyl Ethers (PBDEs) in the INMA Birth Cohort (Spain)

2016

This study looked at predictors of exposure to polybrominated diphenyl ethers (PBDEs) with a focus on dietary and household-level factors. Concentrations of BDE-47, -99, -153, and -209 and their sum (∑PBDEs) were measured in cord serum. Spanish women (n = 541) completed two semiquantitative food frequency questionnaires during the first and third trimesters of pregnancy. The daily mean intake (grams) of eggs, dairy products, meat, cereals and pasta, vegetables and pulses, fruits, shellfish and cephalopods, and fish, and the weekly mean intake (servings) of lean, large oily, other oily, and other fish from both questionnaires were averaged. Information on house size, curtains and carpets at …

010501 environmental sciencesThird trimester01 natural sciences03 medical and health sciences0302 clinical medicinePolybrominated diphenyl ethersPregnancyCORD SERUMEnvironmental healthHalogenated Diphenyl EthersAnimalsHumansEnvironmental ChemistryMedicine030212 general & internal medicinePrenatal exposure0105 earth and related environmental sciencesPregnancyFood frequencybusiness.industryGeneral Chemistrymedicine.diseaseDiet3. Good healthSeafoodSpainPrenatal Exposure Delayed EffectsEnvironmental chemistryGestationFemalebusinessBirth cohortEnvironmental Science & Technology
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First-trimester maternal concentrations of polyfluoroalkyl substances and fetal growth throughout pregnancy

2019

Background: Several studies have investigated the possible association between prenatal exposure to perfluoroalkyl substances (PFASs) and birth anthropometry. However, none has assessed fetal size longitudinally. We studied the possible association between PFASs and fetal biometry. Methods: In 1230 mother-child pairs of three cohorts from the Spanish INMA-Project, we analyzed perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) in first-trimester maternal plasma (collection: 2003-2008). We measured abdominal circumference (AC), femur length (FL), biparietal diameter (BPD), and estimated fetal weight (EFW)…

AdultMalePerfluorooctanesulfonic acid010504 meteorology & atmospheric sciencesPFNAFluorine CompoundsPopulationPhysiologyFetal growth010501 environmental sciences01 natural sciencesCohort StudiesFetal DevelopmentPerfluorononanoic acidchemistry.chemical_compoundFetusPregnancyPFASsPFOSHumansMedicineeducationlcsh:Environmental sciences0105 earth and related environmental sciencesGeneral Environmental Sciencelcsh:GE1-350Fetuseducation.field_of_studyPregnancybusiness.industryPFOAPregnancy OutcomeAnthropometrymedicine.disease3. Good healthPregnancy Trimester FirstPFHxSchemistryCohortPerfluorooctanoic acidFemalebusiness
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Exposure to perfluoroalkyl substances and thyroid function in pregnant women and children: A systematic review of epidemiologic studies

2017

Introduction: Thyroid hormones (THs) are especially important for brain maturation and development during the fetal period and childhood. Several epidemiological studies have assessed the possible association between exposure to perfluoroalkyl substances (PFAS) and thyroid outcomes during the early stages of life. We aimed to review this evidence. Methods: We conducted a systematic review in compliance with the PRISMA Statement (search conducted in PubMed and Embase, as well as in the citations of the selected articles). We chose studies if they dealt with thyroid-stimulating hormone (TSH), triiodothyronine (T3), thyroxin (T4), or thyroid dysfunctions, and perfluorohexane sulfonate (PFHxS),…

0301 basic medicineMalemedicine.medical_specialtyAdolescentPrenatal and infant exposureThyroid GlandPhysiology010501 environmental sciences01 natural sciencesPerfluorononanoic acidToxicology03 medical and health scienceschemistry.chemical_compoundEnvironmental Science(all)PregnancyEpidemiologymedicineHumansPerfluorononanoic acid (PFNA)Childlcsh:Environmental sciences0105 earth and related environmental sciencesGeneral Environmental Sciencelcsh:GE1-350ThyroidFluorocarbonsTriiodothyroninebusiness.industryThyroidEnvironmental ExposurePerfluorohexane sulfonate (PFHxS)3. Good healthPerfluorooctane030104 developmental biologymedicine.anatomical_structurechemistryAlkanesulfonic AcidsEnvironmental PollutantsFemalePerfluorooctane sulfonate (PFOS)Thyroid functionCaprylatesPerfluorooctanoic acid (PFOA)businessHormoneCohort studyEnvironment International
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