0000000000142183

AUTHOR

Andrea Von Berg

showing 10 related works from this author

Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitis

2020

Atopic dermatitis (AD) is a prevalent inflammatory skin disease. Loss-of-function mutations in filaggrin gene (FLG) represent the strongest genetic risk factors for AD, being strongly associated with early disease onset and persistence into adulthood.1 The epidermis of individuals with mutations in FLG is fundamentally different from normal skin being characterized by increased penetration of allergens.2 Recent birth cohort studies showed a significant interaction between cat ownership at birth and mutations in FLG (R501X, 2282del4) on the development of early-onset AD.3 This finding was replicated for the 2282del4 FLG mutation in a Dutch cohort study, and extended to further associate with…

AllergyAllergyImmunologyFilaggrin ProteinsDermatitis Atopic03 medical and health sciences0302 clinical medicineCAT EXPOSUREIntermediate Filament ProteinsmedicineImmunology and AllergyAnimalsHumansGenetic Predisposition to Disease030304 developmental biologyRISK0303 health sciencesScience & TechnologyCATSbusiness.industryInfant NewbornAtopic dermatitismedicine.disease030228 respiratory system1107 ImmunologyMutation (genetic algorithm)ImmunologyMutationCatsbusinessLife Sciences & BiomedicineFilaggrinAllergy
researchProduct

Association of Gestational Weight Gain With Adverse Maternal and Infant Outcomes

2019

Importance: Both low and high gestational weight gain have been associated with adverse maternal and infant outcomes, but optimal gestational weight gain remains uncertain and not well defined for all prepregnancy weight ranges. Objectives: To examine the association of ranges of gestational weight gain with risk of adverse maternal and infant outcomes and estimate optimal gestational weight gain ranges across prepregnancy body mass index categories. Design, setting, and participants: Individual participant-level meta-analysis using data from 196 670 participants within 25 cohort studies from Europe and North America (main study sample). Optimal gestational weight gain ranges were estimated…

Gestational hypertensionNutrition and Disease01 natural sciencesBody Mass Index0302 clinical medicinePregnancyVoeding en ZiekteMedicineBirth Weight030212 general & internal medicineObstetricsDiabetesPregnancy OutcomeGestational ageGeneral MedicineCesarean Section/statistics & numerical dataAdult; Birth Weight; Cesarean Section; Diabetes Gestational; Female; Humans; Hypertension Pregnancy-Induced; Infant Newborn; Obesity; Pregnancy; Premature Birth; Body Mass Index; Gestational Weight Gain; Pregnancy Complications; Pregnancy OutcomeGestational Weight GainGestational diabetesPremature birthGestationalHypertensionPremature BirthFemalemedicine.symptomUnderweightPREGNANT-WOMENAdultmedicine.medical_specialtyBirth weightPregnancy-InducedHealthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18]03 medical and health sciencesAll institutes and research themes of the Radboud University Medical CenterLife ScienceHumansObesity0101 mathematicsbusiness.industryCesarean Section010102 general mathematicsInfant NewbornInfantHypertension Pregnancy-Inducedmedicine.diseaseNewbornReconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10]BODY-MASS INDEXPregnancy ComplicationsDiabetes GestationalbusinessBody mass indexWeight gain
researchProduct

Mechanisms of the Development of Allergy (MeDALL) : Introducing novel concepts in allergy phenotypes

2017

Asthma, rhinitis, and eczema are complex diseases with multiple genetic and environmental factors interlinked through IgE-associated and non–IgE-associated mechanisms. Mechanisms of the Development of ALLergy (MeDALL; EU FP7-CP-IP; project no: 261357; 2010-2015) studied the complex links of allergic diseases at the clinical and mechanistic levels by linking epidemiologic, clinical, and mechanistic research, including in vivo and in vitro models. MeDALL integrated 14 European birth cohorts, including 44,010 participants and 160 cohort follow-ups between pregnancy and age 20 years. Thirteen thousand children were prospectively followed after puberty by using a newly standardized MeDALL Core Q…

0301 basic medicineAllergyGenome-wide association studyComorbidityImmunoglobulin Emedicine.disease_causeCohort StudiesTranslational Research Biomedical0302 clinical medicineAllergenREGULATORY B-CELLSPRECISION MEDICINEMedicineBIRTH COHORT INFANTSATOPIC-DERMATITISImmunology and Allergy[SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/AllergologyChildmedia_commonbiologyatopic dermatitisAtopic dermatitis3. Good healthEuropeMulticenter StudyCHRONIC RESPIRATORY-DISEASESrhinitiPhenotypeINNER-CITY CHILDRENBiomarker (medicine)Femaleatopic dermatitiAdolescentEUROPEAN INNOVATION PARTNERSHIPImmunologyreview03 medical and health sciencesEARLY-LIFEYoung AdultrhinitisAllergy ; Asthma ; Atopic Dermatitis ; RhinitisHypersensitivityJournal Articlemedia_common.cataloged_instanceAnimalsHumansEuropean unionAsthmaMOUNTAIN CEDAR POLLINOSISbusiness.industryGene Expression ProfilingCHILDHOOD ASTHMAAllergensImmunoglobulin Emedicine.diseaseallergyAsthma030104 developmental biology030228 respiratory systemImmunologybiology.proteinImmunizationbusinessGenome-Wide Association StudyJournal of Allergy and Clinical Immunology
researchProduct

Air Pollution Exposure During Pregnancy and Symptoms of Attention Deficit and Hyperactivity Disorder in Children in Europe

2018

Background: Exposure to air pollution during pregnancy may increase attention-deficit/hyperactivity disorder (ADHD) symptoms in children, but findings have been inconsistent. We aimed to study this association in a collaborative study of eight European population-based birth/child cohorts, including 29,127 mother-child pairs. Methods: Air pollution concentrations (nitrogen dioxide [NO2] and particulate matter [PM]) were estimated at the birth address by land-use regression models based on monitoring campaigns performed between 2008 and 2011. We extrapolated concentrations back in time to exact pregnancy periods. Teachers or parents assessed ADHD symptoms at 3-10 years of age. We classified …

Pediatricsmedicine.medical_specialtyEpidemiologyNitrogen DioxideEnvironmental pollution010501 environmental sciences01 natural sciencesOdds03 medical and health sciences0302 clinical medicinePregnancyAir PollutionmedicineHumanslongitudinal studies030212 general & internal medicineChildProspective cohort study0105 earth and related environmental scienceschild developmentparticulate matterInhalation ExposurePregnancybusiness.industryattention deficit disorder with hyperactivityOdds ratiomedicine.diseaseChild developmentConfidence intervalprospective studies3. Good healthEuropemeta-analysisnitrogen oxidesChild PreschoolPrenatal Exposure Delayed EffectsMeta-analysisFemaleenvironmental pollutionAttention Deficit Disorder With Hyperactivity ; Child Development ; Environmental Pollution ; Longitudinal Studies ; Meta-analysis ; Nitrogen Oxides ; Particulate Matter ; Prospective Studiesbusiness
researchProduct

Does early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts

2018

The parallel epidemics of childhood asthma and obesity over the past few decades have spurred research into obesity as a risk factor for asthma. However, little is known regarding the role of asthma in obesity incidence. We examined whether early-onset asthma and related phenotypes are associated with the risk of developing obesity in childhood.This study includes 21 130 children born from 1990 to 2008 in Denmark, France, Germany, Greece, Italy, The Netherlands, Spain, Sweden and the UK. We followed non-obese children at 3-4 years of age for incident obesity up to 8 years of age. Physician-diagnosed asthma, wheezing and allergic rhinitis were assessed up to 3-4 years of age.Children with ph…

Pulmonary and Respiratory MedicineMaleAllergyPediatricsmedicine.medical_specialtyPediatric ObesityInfants -- MalaltiesCHILDRENOverweightPROFILEChildhood obesityArticleCohort Studies03 medical and health sciences0302 clinical medicineSDG 3 - Good Health and Well-beingRisk FactorsWheezemedicineHumans030212 general & internal medicineRisk factorAge of OnsetChildAsmaAsthmaRespiratory SoundsOVERWEIGHTbusiness.industryINCIDENT ASTHMAmedicine.diseaseObesityRhinitis AllergicAsthma3. Good healthrespiratory tract diseasesBODY-MASS INDEXALLERGYEuropePhenotype030228 respiratory systemChild PreschoolObesitatFemaleAge of onsetmedicine.symptombusiness
researchProduct

Add-on salmeterol compared to double dose fluticasone in pediatric asthma: A double-blind, randomized trial (VIAPAED)

2009

Rationale In asthmatic children whose symptoms are uncontrolled on standard doses of inhaled corticosteroids (ICS), guidelines recommend to either increase the ICS dose or to add further controller medication, e.g. a long acting s2-agonist (LABA). The aim of this study was to compare the efficacy and safety of doubling the dose of ICS (fluticasone proprionate FP 200 µg twice daily) with adding a long-acting beta-2 agonist to the ICS (SFC, salmeterol 50 µg/ FP 100 µg twice daily) in children with uncontrolled asthma. Methods Children between 4 and 16 years of age were eligible for this multicenter, randomized, double blind, double dummy, parallel-group study. During a 14-day run-in phase, al…

Pulmonary and Respiratory Medicinemedicine.medical_specialtybusiness.industryInhalerInterim analysismedicine.diseaselaw.inventionRandomized controlled triallawInternal medicineAnesthesiaPediatrics Perinatology and Child HealthmedicineClinical endpointSalbutamolSalmeterolbusinessAsthmamedicine.drugFluticasonePediatric Pulmonology
researchProduct

Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, …

2019

ObjectiveTo assess the separate and combined associations of maternal pre‐pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact.DesignIndividual participant data meta‐analysis of 39 cohorts.SettingEurope, North America, and Oceania.Population265 270 births.MethodsInformation on maternal pre‐pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used.Main outcome measuresGestational hypertension, pre‐eclampsia, gestational diabetes, preterm birth, small and large for gestational age at birth.ResultsHigher maternal pre‐pregnancy BMI and gesta…

Gestational hypertensionand promotion of well-beingNutrition and DiseaseBirthweightReproductive health and childbirthLow Birth Weight and Health of the NewbornCardiovascularMedical and Health SciencesDISEASECohort Studies0302 clinical medicine3123 Gynaecology and paediatricsRisk FactorsPregnancyVoeding en ZiekteInfant MortalityOdds RatioMedicineBirth Weight2.1 Biological and endogenous factorsEPIDEMIOLOGYwq_200Aetiology2. Zero hungerPediatricRISKeducation.field_of_studyOUTCOMES030219 obstetrics & reproductive medicineObstetricspregnancy complicationsDiabetesObstetrics and GynecologyGestational ageweight gainASSOCIATIONGestational Weight GainGestational diabetesEuropeBirthweight ; Body Mass Index ; Pregnancy Complications ; Preterm Birth ; Weight GainOBESITYFemalemedicine.symptomAdultmedicine.medical_specialtyPRETERM BIRTHBirth weightPopulationGestational Agebody mass index[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetricswa_310Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18]03 medical and health sciencesAll institutes and research themes of the Radboud University Medical CenterPretermClinical ResearchHumanswq_100ObesityeducationObstetrics & Reproductive MedicineMetabolic and endocrineNutritionPregnancybusiness.industryContraception/ReproductionPreventionBirthweight; body mass index; pregnancy complications; preterm birth; weight gainAustraliaInfantbirth weightpreterm birthDIABETES-MELLITUSPreterm birth weight gainOverweightPerinatal Period - Conditions Originating in Perinatal Periodmedicine.diseaseNewbornPrevention of disease and conditionsReconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10]Good Health and Well BeingNorth America3.1 Primary prevention interventions to modify behaviours or promote wellbeingpregnancy complicationbusinessWeight gainBody mass indexwb_200
researchProduct

Changes in parental smoking during pregnancy and risks of adverse birth outcomes and childhood overweight in Europe and North America

2020

Background Fetal smoke exposure is a common and key avoidable risk factor for birth complications and seems to influence later risk of overweight. It is unclear whether this increased risk is also present if mothers smoke during the first trimester only or reduce the number of cigarettes during pregnancy, or when only fathers smoke. We aimed to assess the associations of parental smoking during pregnancy, specifically of quitting or reducing smoking and maternal and paternal smoking combined, with preterm birth, small size for gestational age, and childhood overweight. Methods and findings We performed an individual participant data meta-analysis among 229,158 families from 28 pregnancy/bir…

MaleParentsembarazoEpidemiologyMaternal HealthSocial SciencesCHILDREN0302 clinical medicinePregnancynacimiento prematuroSmoking/adverse effectsPsychologyMATERNAL SMOKINGestudios de cohortesBody mass indexeducation.field_of_studyGeneral MedicineASSOCIATION16. Peace & justice3. Good healthPrenatal Exposure Delayed EffectsMedicineGROWTHefectos diferidos por exposición prenatalCohort studyHumanPRETERM BIRTHEurope/epidemiology03 medical and health sciencesHumansSmoking habitsRisk factoreducationBehaviorPregnancyBiology and Life SciencesInfantOdds ratiohábito de fumarmedicine.diseasePregnancy ComplicationsCESSATIONDemographyPediatric ObesityPhysiologyhumanos030204 cardiovascular system & hematologyOverweightNorth America/epidemiologyCohort StudiesHabitsRisk FactorsMedicine and Health Sciences030212 general & internal medicineDNA METHYLATIONSmokingRObstetrics and GynecologyGestational ageedad gestacionalPrenatal Exposure Delayed Effects/diagnosis3142 Public health care science environmental and occupational healthobesidad pediátricaPediatric Obesity/diagnosisEuropePhysiological ParametersCohort Studies; Europe; Female; Gestational Age; Humans; Infant Newborn; Male; North America; Pediatric Obesity; Pregnancy; Premature Birth; Prenatal Exposure Delayed Effects; Risk Factors; Smoking; ParentsOBESITYPremature BirthFemalemedicine.symptomResearch ArticleBirth weightPopulationPremature Birth/diagnosisGestational AgepadresPrenatal Exposure Delayed EffectHealthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18]All institutes and research themes of the Radboud University Medical CenterBirth weightmedicinefactores de riesgoEXPOSURElactantebusiness.industryRisk FactorBody WeightInfant NewbornOverweightNewbornReconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10]Medical risk factors3121 General medicine internal medicine and other clinical medicineNorth AmericaBirthWomen's HealthWEIGHTCohort Studiebusiness[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyPLOS Medicine
researchProduct

Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: An individual participant data meta-analy…

2019

Background Maternal obesity and excessive gestational weight gain may have persistent effects on offspring fat development. However, it remains unclear whether these effects differ by severity of obesity, and whether these effects are restricted to the extremes of maternal body mass index (BMI) and gestational weight gain. We aimed to assess the separate and combined associations of maternal BMI and gestational weight gain with the risk of overweight/obesity throughout childhood, and their population impact. Methods and findings We conducted an individual participant data meta-analysis of data from 162,129 mothers and their children from 37 pregnancy and birth cohort studies from Europe, No…

Data AnalysisembarazoMaternal HealthBlood PressureCHILDRENWeight GainCardiovascularVascular MedicineBody Mass Index0302 clinical medicineEndocrinologyPregnancyMedicineMass indexestudios de cohortesCancer030219 obstetrics & reproductive medicineStatisticsWOMENta3141General Medicine030220 oncology & carcinogenesisMeta-analysisPhysical SciencesMedicineGestationHEALTHINTERVENTIONChildhood ObesityEndocrine Disorders03 medical and health sciencesHypertensive Disorders in PregnancyClinical ResearchDiabetes MellitusHumansGestational DiabetesStatistical MethodsPregnancyIndividual participant dataPreventionAustraliaBiology and Life SciencesOdds ratiomedicine.diseaseObesityGeneric health relevanceBody mass indexMathematicsDemographyPediatric ObesityNutrition and DiseasePhysiologyhumanosReproductive health and childbirth030204 cardiovascular system & hematologyOverweightMedical and Health SciencesOral and gastrointestinalCohort StudiesMathematical and Statistical TechniquesRisk FactorsVoeding en ZiekteOFFSPRING OBESITYMedicine and Health Sciences030212 general & internal medicineChildhood obesity2. Zero hungerPediatricsobrepesoMedicine (all)RObstetrics and GynecologyMetaanalysis3142 Public health care science environmental and occupational healthGestational Weight Gainobesidad pediátricaEuropeStrokePREGNANCYPhysiological Parametersgestational weight gain pregnancy obesityHypertensionFemalemedicine.symptomResearch ArticleBIRTH[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetricsResearch and Analysis MethodsChildhood obesityGeneral & Internal Medicinefactores de riesgoLife ScienceObesityMetabolic and endocrineNutritionbusiness.industryíndice de masa corporalBody WeightOverweight3121 General medicine internal medicine and other clinical medicineMetabolic DisordersNorth AmericaWomen's HealthbusinessMaternal bodyGestiational diabetesWeight gainPLOS Medicine
researchProduct

Variations in the prevalence of childhood asthma and wheeze in MeDALL cohorts in Europe.

2017

While there is evidence for variations in prevalence rates of childhood wheeze and asthma between countries, longitudinal, individual-level data are needed to understand these differences. The aim of this study was to examine variations in prevalence rates of childhood asthma, wheeze and wheeze with asthma in Europe. We analysed datasets from 10 MeDALL (Mechanisms of the Development of ALLergy) cohorts in eight countries, representing 26 663 children, to calculate prevalence rates of wheeze and asthma by child age and wheeze with asthma at age 4 years. Harmonised variables included outcomes parent-reported wheeze and parent-reported doctor-diagnosed asthma, and covariates maternal education…

Pulmonary and Respiratory MedicinePediatricsmedicine.medical_specialtyAllergy5Child age12Prevalencelcsh:MedicineChildhood asthma03 medical and health sciences0302 clinical medicineimmune system diseasesWheezeJournal Articlemedicine030212 general & internal medicineSleep medicineAsthmaChildhood asthmaAsthma and allergybusiness.industrylcsh:ROriginal Articlesmedicine.disease3. Good healthrespiratory tract diseasesMaternal educationCOPD and smoking030228 respiratory systemmedicine.symptombusinessDemography
researchProduct