6533b7d1fe1ef96bd125c2d2
RESEARCH PRODUCT
Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitis
Jonathan O'b HourihaneJonathan O'b HourihaneHans BisgaardJoachim HeinrichJoachim HeinrichSuzanne G.m.a. PasmansIngo MarenholzIngo MarenholzPeter BagerCarol A. WangNiels J. ElbertTamara SchikowskiLavinia PaternosterAna EspluguesYoung-ae LeeYoung-ae LeeDonnchadh M. O'sullivanChen HuCraig E. PennellPatrick G. HoltGunda HerberthNatalia BallardiniMariona BustamanteAdnan CustovicAndrea Von BergMads MelbyeMads MelbyeMads MelbyeErik MelénBo L. ChawesLiesbeth DuijtsMaties TorrentJakob StokholmMarie StandlKlaus BønnelykkeAnna BergströmTarunveer S. AhluwaliaJohn A. CurtinAngela SimpsonJacob P. ThyssenTamar NijstenSusanne Lausubject
AllergyAllergyImmunologyFilaggrin ProteinsDermatitis Atopic03 medical and health sciences0302 clinical medicineCAT EXPOSUREIntermediate Filament ProteinsmedicineImmunology and AllergyAnimalsHumansGenetic Predisposition to Disease030304 developmental biologyRISK0303 health sciencesScience & TechnologyCATSbusiness.industryInfant NewbornAtopic dermatitismedicine.disease030228 respiratory system1107 ImmunologyMutation (genetic algorithm)ImmunologyMutationCatsbusinessLife Sciences & BiomedicineFilaggrindescription
Atopic dermatitis (AD) is a prevalent inflammatory skin disease. Loss-of-function mutations in filaggrin gene (FLG) represent the strongest genetic risk factors for AD, being strongly associated with early disease onset and persistence into adulthood.1 The epidermis of individuals with mutations in FLG is fundamentally different from normal skin being characterized by increased penetration of allergens.2 Recent birth cohort studies showed a significant interaction between cat ownership at birth and mutations in FLG (R501X, 2282del4) on the development of early-onset AD.3 This finding was replicated for the 2282del4 FLG mutation in a Dutch cohort study, and extended to further associate with risk of allergic sensitization.4 We performed analyses in multiple birth cohorts to examine the consistency and overall strength of the previously observed interaction.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-02-05 | Allergy |