Search results for "amiinit"
showing 10 items of 22 documents
Iodonium complexes of the tertiary amines quinuclidine and 1-ethylpiperidine
2021
Iodonium complexes incorporating tertiary amines have been synthesised to study and explore why such species comprised of alkyl amines are relatively rare. The complexes were characterised in solution (1H and 15N NMR spectroscopy) and the solid state (SCXRD), and analysed computationally. peerReviewed
Revisited Dual Luminescence of 2,2′-Dipyridylamine Hydrochloride in Solution and Physical Processes behind It
2018
Structural studies on filamin domain interactions
2015
Three proteins regulating integrin function - filamin, 14-3-3 and RIAM
2011
Trans-(2,5)-disubstituoitujen pyrrolidiiniyhdisteiden enantioselektiivinen synteesi
2018
2,5-disubstituoitujen pyrrolidiinien enantioselektiivistä synteesiä on tutkittu paljon, sillä pyrrolidiinirakenne löytyy monista alkaloideista ja on täten tärkeä osa luonnonainesynteesiä. Lisäksi ne toimivat tärkeinä asymmetrisen synteesin työkaluina. Erityisen kiinnostavia tässä suhteessa ovat erilaiset trans-2,5-bisaryylipyrrolidiinit katalyyttisten ominaisuuksiensa vuoksi. Tässä tutkielmassa käydään läpi eräitä tapoja niiden syntetisoimiseksi. Tutkielmassa keskitytään erityisesti trans-2,5-difenyylipyrrolidiinin enantioselektiiviseen synteesiin.
One-Pot Synthesis, X-ray Single Crystal and Molecular Insight of Enaminone-Based β-Morpholino-/N-Methylpiperazinyl-/Pyrrolidinylpropiophenone
2020
One-pot synthesis of three enaminones, (E)-1-(4-chlorophenyl)-3-morpholinoprop-2-en-1-one 1, (E)-1-(4-chlorophenyl)-3-(4-methylpiperazin-1-yl)prop-2-en-1-one 2, and (E)-1-(4-chlorophenyl)-3-(pyrrolidin-1-yl)prop-2-en-1-one 3 were achieved. The synthetic protocol via three components reaction of p-chloroacetophenone with DMFDMA (N,N-dimethylformamid-dimethylacetal) and the corresponding secondary amines (morpholine/N-methylpiperazine/pyrrolidine) in dioxane under heating for 2.5–4 h at 102 °C yielded the requisite enaminones. This protocol has the advantage of no separation of intermediate, no need for column purification with quantitative yield for the target compounds. The chemical feature…
Inter-domain interactions in filamins
2014
Stereocontrolled synthesis of fluorine-containing piperidine γ-amino acid derivatives
2019
An efficient synthetic approach for the construction of fluorine‐containing piperidine γ‐amino acid derivatives has been developed. The synthetic concept was based on oxidative ring opening of an unsaturated bicyclic γ‐lactam (Vince‐lactam) through its ring C=C bond, followed by double reductive amination of the diformyl intermediate performed with various fluoroalkylamines. The method has been extended towards the access of alkylated and perfluoroalkylated substances and for γ‐lactam derivatives. The transformations proceeded with stereocontrol: the configuration of the stereocenters in the products were predetermined by the configuration of the chiral centers of the starting γ‐lactam. The…
Water-Soluble Cuprizone Derivative: Synthesis, Characterization, and in Vitro Studies
2019
The cuprizone mouse model is one of the most accepted model systems for the investigation of oligodendrocyte degeneration, a process critically involved in the pathogenesis of diseases such as multiple sclerosis or schizophrenia. In order to substitute the in vivo experiments by in vitro approaches, the amine derivative BiMPi is introduced as a water-soluble alternative to cuprizone. Regarding superoxide dismutase activity, toxicity for oligodendrocytes, and disturbance of mitochondrial membrane potential, BiMPi shows similar in vitro effects as is observed in vivo for cuprizone. peerReviewed