Search results for "amine"

The metaphysics behind pharmacotherapy: treating depression with conventional and psychedelic drugs

2018

This paper aims to explore and compare the metaphysical entailments of the conventional psychopharmacological approach in the treatment of depression to those of a psychedelic approach. We will examine the thesis by which knowledge of how drugs act upon us shapes our self-image and our understanding of psychopathology––and defend that this process can only take place in a supportive environment. It is commonly claimed that the nature of depression was shaped after the therapeutic success of antidepressants; nevertheless, psychedelic drugs were at least as successful as antidepressants, and they didn’t end up having the same power to influence our views. It was possible for first and second-…

Chanching the externalizing and internalizing spectrum of personality with self-regultaion therapy

2018

This article presents an integrator model of changes in the externalizing and internalizing factors of personality grouped in the General Factor of Personality (GFP), based on the Unique Trait Personality Theory (UTPT) [1]. This theory proposes that a continuum exists between personality and psychopathology, as well as the existence of a GFP that occupies the apex of the hierarchy of personality, and extends from an impulsiveness-and-aggressiveness pole (externalizing spectrum) to an anxiety-and-introversion pole (internalizing spectrum). With an experimental intra-group design, 30 regular users of stimulant drugs (cocaine and amphetamine) used the Self-Regulation Therapy (SRT). The SRT is …

Studies of polyamines transport through liquid membranes with D2EHPA as a carrier.

2008

The transport of polyamines through the liquid membranes with di‐2‐ethylhexyl phosphoric acid (D2EHPA) was investigated. The study was performed in three main steps: liquid–liquid extraction (LLE), bulk liquid membrane (BLM) extraction, and supported liquid membrane (SLM) extraction. Equilibrium distribution experiments allowed determining the extraction constants and stoichiometric coefficients for each polyamine. It turned out that one amino group binds two molecules of carrier (one D2EHPA dimer) and the extractability of polyamine rises with the increase in number of function groups in the molecule. The BLM and SLM experiments showed that despite considerable differences in distribution …

(Pathologies of) Recognition in Schelling's Thought on Evil

2015

Fibroblast growth factor-21 enhances mitochondrial functions and increases the activity of PGC-1α in human dopaminergic neurons via Sirtuin-1

2014

Abstract Mitochondrial dysfunctions accompany several neurodegenerative disorders and contribute to disease pathogenesis among others in Parkinson’s disease (PD). Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) is a major regulator of mitochondrial functions and biogenesis, and was suggested as a therapeutic target in PD. PGC-1α is regulated by both transcriptional and posttranslational events involving also the action of growth factors. Fibroblast growth factor-21 (FGF21) is a regulator of glucose and fatty acid metabolism in the body but little is known about its action in the brain. We show here that FGF21 increased the levels and activity of PGC-1α and elevated mito…

Automatic image-based identification and biomass estimation of invertebrates

2020

1. Understanding how biological communities respond to environmental changes is a key challenge in ecology and ecosystem management. The apparent decline of insect populations necessitates more biomonitoring but the time-consuming sorting and expert-based identification of taxa pose strong limitations on how many insect samples can be processed. In turn, this affects the scale of efforts to map and monitor invertebrate diversity altogether. Given recent advances in computer vision, we propose to enhance the standard human expert-based identification approach involving manual sorting and identification with an automatic image-based technology. 2. We describe a robot-enabled image-based ident…

Software startup education: gamifying growth hacking

2021

Startups seek to create highly scalable business models. For startups, growth is thus vital. Growth hacking is a marketing strategy advocated by various startup practitioner experts. It focuses on using low cost practices while utilizing existing platforms in creative ways to gain more users for the service. Though topics related to growth hacking such as marketing on a general level have been extensively studied in the past, growth hacking as a practitioner-born topic has not seen much interest among the academia. To both spark interest in growth hacking, and to facilitate teaching growth hacking in the academia, we present two board games intended to serve as an engaging introduction to g…

Towards a Trustful Digital World : Exploring Self-Sovereign Identity Ecosystems

2021

In the current global situation-burdened by, among others, a vast number of people without formal identification, digital leap, the need for health passports and contact tracking applications-providing private and secure digital identity for individuals, organizations and other entities is crucial. The emerging self-sovereign identity (SSI) solutions rely on distributed ledger technologies and verifiable credentials and have the potential to enable trustful digital interactions. In this human-centric paradigm, trust among actors can be established in a decentralized manner while the identity holders are able to own and control their confidential data. In this paper, we build on observations…

Phenothiazine-based dyes for efficient dye-sensitized solar cells

2016

As an emerging photovoltaic technology, dye-sensitized solar cells (DSSCs) have attracted a great deal of academic and industrial interest due to their reasonably high power conversion efficiency, low material cost and facile fabrication process. Metal-free organic dyes, as one of the key components of DSSCs, play a pivotal role in light harvesting and electron injection. Among the various species of organic dyes, easily tunable 10H-phenothiazine-based dyes hold a large proportion. The electron-rich nitrogen and sulfur atoms render 10H-phenothiazine a stronger donor character than other amines, even better than triphenylamine, tetrahydroquinoline, carbazole and iminodibenzyl. On the other h…

Template-assisted fabrication of free-standing nanorod arrays of a hole-conducting cross-linked triphenylamine derivative: toward ordered bulk-hetero…

2009

Free-standing nanorod arrays of a thermally cross-linked semiconducting triphenylamine were fabricated on conductive ITO/glass substrates via an anodic aluminum oxide (AAO) template-assisted approach. By using a solution wetting method combined with a subsequent thermal imprinting step to fill the nanoporous structure of the template with a cross-linkable triphenylamine derivative, a polymeric replication of the AAO was obtained after thermal curing and selective removal of the template. To obtain well-aligned and free-standing nanorod arrays, aggregation and collapse of the nanorods were prevented by optimizing their aspect ratio and applying a freeze-drying technique to remove the aqueous…