Search results for "aminoacids"
showing 10 items of 13 documents
An Efficient Synthesis of γ-Aminoacids and Attempts to Drive Its Enantioselectivity
2008
Addition of carboxylic acid dianions to bromoacetonitrile lead, in good yields,to the corresponding gamma-cyanoacids, which on hydrogenation yielded gamma-amino acids. This two step methodology improves upon previously described results. Poor e.e's resultedfrom our attempts to drive the enantioselectivity of this transformation by chiral amide induction.
NANOTECHNOLOGIES FOR BIOMEDICAL APLICATIONS
2010
Low-Q peak in X-ray patterns of choline-phenylalanine and homophenylalanine: a combined effect of chain and stacking
2016
Abstract In this contribution we report for the first time the X-ray patterns of choline-phenylalanine and choline-homophenylalanine ionic liquids. The presence of a low Q peak in both systems is another evidence that a long alkyl chain is not always needed to establish a nanodomain segregation in the liquid sufficient to be revealed by the diffraction experiment. These new data are compared with the diffraction patterns and the theoretical calculations of other choline-aminoacid ionic liquids recently reported. A significant role might be played by the stacking interactions between aromatic rings.
Complexes of diorganotin(IV) with aminoacids and a dipeptide. Synthesis and structural investigations.
2008
The aim of this work is to synthesize complexes of Arginine, effector of recognition, with organotin(IV) ions (R2Sn2+, R =Me, nBu) which are known to possess antitumour, antimicrobial, anti-inflammatory activities. The complexes were investigated by FT-IR and 119Sn Můssbauer.While identical stoichiometries are present for Me2Sn(Arg)2 and Me2Sn(Boc-Arg)2 complexes, 119Sn Můssbauer spectra give a clear evidence of different coordination modes. L-Arginine appears to behave as a chelating ligand through carboxylate and a-NH2 groups in the former, while in Nα-Boc-L-Arginine complex, the Nα-protected amino group being exempted from coordination, only the carboxylate groups are effectors of bondin…
Synthèse de pinces à fluorures dérivées d'aminoacides pour l'imagerie TEP
2014
This thesis project, which is part of a collaboration between the Institut de Chimie Moléculaire de l’Université de Bourgogne and the Positron Emission Tomography Research Centre, is about the synthesis of fluoride pincers derived from amino acids based on 18F-B bond construction to get a new class of PET imaging agents. First, this project concerned the design, synthesis and characterisation of new boronato and trifluoroborato phosphonium amino acid salts. Quaternisation of o-boronate phenyl phosphine with β-iodo amino esters or γ-iodo amino ester leads to the corresponding salts without racemisation and in yields up to 88%. Saponification of boronato phosphonium amino esters afford the fr…
SCAFFOLDS BASED ON HYALURONIC ACID AND POLYAMINOACIDS AS ARTIFICIAL ECM SUBSTITUTES
2009
HYBRID SYSTEMS FOR TISSUE ENGINEERING
2009
Hastening of wound healing of mucosa by means of aminoacids combined to sodium hyaluronate after oral biopsy: an open trial.
2014
Sodium hyaluronate has been widely used in order to promote wound healing in oral cavity for its anti-inflammatory effects. Aim of this clinical trial was to evaluate the efficacy of aminoacids added to topical sodium hyaluronate, in minor oral surgery. After surgery by means of Quantic molecular resonance scalpel, in 27 patients a gel with sodium hyaluronate has been applied directly on the surgical wound, in order to favorite healing by secondary intention. Furthermore, gel has been applied 3-4times/day, after meals and oral hygiene. Hemostatic effect, edema and pain symptoms by VAS (Visual Analogue Scale;0-100), and clinical healing (full, partial, absent) have been evaluated at T#1(2hrs…
Streoselective hemisynthesis of heterosubstituted aminoacidsApplication on radiofluorolabeling for peptide imaging.
2017
Stereoselective hemisynthesis of lateral chain heterosubstituted aminoacids.Applications on radiofluorolabeling for peptide imaging.This thesis work, which was carried out at the Institute of Molecular Chemistry of the University of Burgundy and in collaboration with the Institute of Cognitive and Integrative Neurosciences of Aquitaine, focuses on the development of new methods for the synthesis of side chain heterosubstituted amino acids including phosphine containing or silyl groups, as well as on their applications. In a first part, the synthesis of side chain silylated amino acids is achieved without racemization using a key Wittig reaction between a phosphonium salt, derived from L-asp…