Search results for "analgesia"

Continuous Femoral Catheter for Postoperative Analgesia After Total Knee Arthroplasty

2020

Introduction Postoperative pain management in the total knee replacement (TKR) represent a fundamental step for a positive outcome, allowing rapid mobilization, already on the first day. Further, continuous peripheral nerve block techniques have been reported to allow effective and safe control of acute postoperative pain, ensuring the implementation and completion of an accurate and intensive joint rehabilitation program. Aim The aim of this study was to assess early mobility and compliance of patients that underwent TKR surgery using the femoral block. Methods For the study, all patients that underwent TKR from 2015 to 2018 with ASA score between II-III was evaluated. Patients underwent v…

Intraoperative clonidine modulates sympathetic tone in the early postoperative period after remifentanil. A double blind, placebo-controlled study

1999

Abstract Aim of the study : Severe pain following major surgery can impair the control of the cardiovascular system (CVS) by causing sympathetic stimulation, possibly leading to myocardial ischaemia. In this study we examine the influence of intraoperative intravenous (i.v.) clonidine infusion on postoperative analgesia and blood concentrations of noradrenaline and adrenaline after major gynaecological surgery. Methods : All patients underwent an abdominal hysterectomy under balanced general anaesthesia using the new opioid remifentanil. The patients were randomised to receive either 5 μg kg −1 of i.v. clonidine intraoperatively ( n =20), or placebo ( n =20). Over a period of 240 minutes po…

Chemical stability of tramadol hydrochloride injection admixed with selected pain drugs

2011

Background: Tramadol hydrochloride (HCl) and ketorolac tromethamine are analgesic drugs, which are commonly used in combination in postoperative pain management. According to some studies, metoclopramide and magnesium sulfate (MgSO4 ) as adjuvant agents can improve analgesia and decrease the need for other pain drugs. Materials and Methods: The chemical stability of tramadol HCl combined with ketorolac tromethamine and metoclopramide HCl has been studied using a stability-indicating high-performance liquid chromatographic assay method. Calibration curves were produced using linear regression of the peak area against concentration of each drug, with an r 2 value ≥ 0.96. Our aim was to invest…

Efficacy of fentanyl transdermal patch in pain control after lower third molar surgery: A preliminary study

2015

Background Surgical removal of impacted lower third molars is a common oral surgical procedure, generally followed by moderate to severe postoperative pain. Transdermal drug delivery as a concept offers interesting possibilities for postoperative pain control. The aim of this study was to evaluate the efficacy of transdermal system with fentanyl in relieving pain following impacted lower third molar surgery. Material and Methods Seventeen patients with bilateral impacted lower third molars were included in this preliminary study. For postoperative pain control, patients randomly received a fentanyl patch plus placebo tablet after the first operation and regular (placebo) patch and an analge…

Opioid switching from and to tapentadol extended release in cancer patients: conversion ratio with other opioids

2013

Objectives: The aim of this exploratory study was to assess the conversion ratios between tapentadol and other opioids in patients requiring an opioid switching. Methods: A prospective study was carried out in a convenience sample of consecutive patients admitted to an acute palliative care unit and a home care unit for a period of 1 year. Patients who were switched from/to tapentadol were selected. The initial ratio between tapentadol and other opioids, expressed as oral morphine equivalents was 1:3.3. The subsequent doses were flexible and were changed to fit the patients’ needs. Pain intensity and distress score were recorded until opioid doses were stable. In all, 37 patients were exami…

Sufentanil sublingual tablet system. From rationale of use to clinical practice

2020

The control of post-operative pain in Italy and other western countries is still suboptimal. In recent years, the Sufentanil Sublingual Tablet System (SSTS; Zalviso; AcelRx Pharmaceuticals, Redwood City, CA, USA), which is designed for patient-controlled analgesia (PCA), has entered clinical practice. SSTS enables patients to manage moderate-to-severe acute pain during the first 72 postoperative hours directly in the hospital setting. However, the role of SSTS within the current framework of options for the management of post-operative pain needs to be better established. This paper presents the position on the use of SSTS of a multidisciplinary group of Italian Experts and provides protoco…

Acupuncture: its neurophysiological basis: an anaesthetist's foreword.

1978

Evaluation of the analgesic action of different fractions from the methanol extract of Teucrium buxifolium L

1998

Different fractions (F-2, F-3, F-5) of the methanol extract from Teucrium buxifolium L. have been tested for their analgesic activity in mice. All of them exhibited peripheral analgesic activity except F-3, Fraction F-5 had the strongest effect and was subjected to a second re-extraction. The subfractions obtained (F-5/3 and F-5/8) exhibited a similar activity to that observed with the whole fraction. (C) 1998 John Wiley & Sons, Ltd.

Evaluation of the acute toxicity, analgesic and CNS activities of different species ofTeucrium genus

1995

Methanol and dichloromethanol extracts of the leaves and stems of four Teucrium species (T. cartaginenses, T. flavum, T. pumillum and T. buxifolium) have been tested for their toxicity, analgesic and central depressor effects. The intraperitoneal administration of the different extracts showed a CNS depressant activity in mice, but they lacked anticonvulsive effects. When tested for analgesic activity none of the extracts increased the threshold of pain thermal stimulus. However, the methanol and dichloromethanol extracts of T. cartaginenses and T. buxifolium species showed a significant analgesic effect in models of pain induced by chemical or mechanical stimulation.

Effects of the prolonged thoracic epidural analgesia on ventilation function and complication rate after the lung cancer surgery.

2006

Thoracic epidural analgesia has been considered to have a good anesthetic efficacy and to decrease the postoperative complication rate, while its effect upon the ventilation function is still the topic of many clinical studies. The aim of this study was to evaluate the course of early postoperative period using thoracic epidural analgesia. Material and methods. A total of 453 patients undergoing the operation due to the non–small cell carcinoma were selected and examined. Their postoperative complications and mortality rate were evaluated. In 79 patients, arterial oxygen saturation (SaO2), forced vital capacity, forced expiratory volume in the first second, and the efficacy of analgesia wer…