Search results for "and K"
showing 10 items of 56 documents
Verso un curricolo 0-6: continuità, discontinuità e prospettive possibili a partire da un percorso di ricerca-azione nella città di Palermo
2021
A partire da una ricerca sulla costruzione di un possibile curricolo zero-sei, condotta con un gruppo di insegnanti di scuola dell’infanzia statale ed un gruppo di educatrici di un nido comunale operanti nello stesso territorio (un quartiere del centro storico di Palermo), l’articolo mira a mettere in luce e a problematizzare ambiti di continuità e di discontinuità tra i due servizi educativi collegandoli alla storia e alla cultura organizzativa dei servizi stessi. Intende, inoltre, riflettere su possibili proposte di cambiamento organizzativo nella direzione della continuità, attraverso l’adozione di una metodologia partecipativa centrata sulla autovalutazione riflessiva, sulla progettazio…
Targeting Phosphatases and Kinases: How to Checkmate Cancer
2021
Metastatic disease represents the major cause of death in oncologic patients worldwide. Accumulating evidence have highlighted the relevance of a small population of cancer cells, named cancer stem cells (CSCs), in the resistance to therapies, as well as cancer recurrence and metastasis. Standard anti-cancer treatments are not always conclusively curative, posing an urgent need to discover new targets for an effective therapy. Kinases and phosphatases are implicated in many cellular processes, such as proliferation, differentiation and oncogenic transformation. These proteins are crucial regulators of intracellular signaling pathways mediating multiple cellular activities. Therefore, altera…
Biophysical approaches for the study of metal-protein interactions
2019
Protein-protein interactions play important roles for a variety of cell functions, often involving metal ions; in fact, metal-ion binding mediates and regulates the activity of a wide range of biomolecules. Enlightening all of the specific features of metal-protein and metal-mediated protein-protein interactions can be a very challenging task; a detailed knowledge of the thermodynamic and spectroscopic parameters and the structural changes of the protein is normally required. For this purpose, many experimental techniques are employed, embracing all fields of Analytical and Bioinorganic Chemistry. In addition, the use of peptide models, reproducing the primary sequence of the metal-binding …
Coppie omosessuali e tutela costituzionale
2015
Le coppie di fatto e quelle omosessuali in particolare sono da tempo una componente della società italiana. La Corte europea dei diritti dell'uomo nella sentenza Schalk and Kopf del 2010 ha riconosciuto la relazione omosessuale come una delle possibili manifestazioni della vita privata e familiare, la cui tutela è sancita dall'art. 8 Cedu. Anche la Corte costituzionale italiana ha attribuito alla relazione omosessuale la connotazione di "formazione sociale", i cui diritti inviolabili sono riconosciuti e garantiti in base all'art. 2 della Costituzione. In questo quadro, stona l'inerzia del legislatore italiano, incapace sino ad ora di disciplinare anche le semplici relazioni di fatto, indipe…
La cueva de El Sidrón (Borines, Piloña, Asturias): primeros resultados
2003
Se exponen los resultados preliminares de las excavaciones arqueológicas llevadas a cabo en la Cueva de El Sidrón entre 2000 y 2002, de acuerdo con los tres objetivos principales que conciernen al registro fósil humano: las características antropológicas, cómo y cuándo llegaron allí y la relación entre fósiles y cultura. Las primeras conclusiones obtenidas son que los restos humanos pertenecen al Neandertal, que el registro arqueológico corresponde a un tecno-complejo del Paleolítico Medio y que están en posición secundaria
Forest structural elements and bryophyte species richness in managed forest landscape
2013
Elektroniskā versija nesatur pielikumus
Nieznane dokumenty dotyczące sejmiku województw poznańskiego i kaliskiego z lat 1701 i 1735 w londyńskich zbiorach archiwalnych. Edycja źródłowa
2022
Odnalezione w londyńskich instytucjach naukowych rękopiśmienne dokumenty związane są z niezwykle burzliwymi okresami w dziejach szlacheckiej Rzeczypospolitej. Instrukcja, a w zasadzie punkty z sejmiku województw poznańskiego i kaliskiego z 1701 r. są związane z początkową fazą Wielkiej Wojny Północnej, która zmieniła układ sił w Europie Środkowo-Wschodniej. Analizowany sejmik został zerwany, a mimo to upubliczniono wyniki jego prac właśnie w formie punktów. Znany polskim historykom dokument nieco odbiega od tego, który znajduje się w londyńskich zbiorach, a różnic, na tym etapie badań, nie jesteśmy w stanie wyjaśnić. Drugi dokument dotyczy tego samego sejmiku, ale z 1735 r., okresu równie b…
Three zone modeling of downdraft biomass gasification : equilibrium and finite kinetic approach
2013
Mathematical models and simulations are being practiced exceedingly in the field of research and development work. Simulations provide a less expensive means of evaluating the benefits and associated risk with applied field. Gasification is a complex mechanism, which incorporates thermochemical conversion of carbon based feedstock. Therefore, simulation of gasification provides a better comprehension of physical and chemical mechanism inside the gasifier than general conjecture and assist in optimizing the yield. The main objectives of present thesis work involve formulation of separate sub-model for pyrolysis and oxidation zone from published scientific references, and assembling it with p…
Forest act habitats : Finnish woodland key habitats amid the intensive forestry
2014
Predicting valuable forest habitats using an indicator species for biodiversity
2020
Intensive management of boreal forests impairs forest biodiversity and species of old-growth forest. Effective measures to support biodiversity require detection of locations valuable for conservation. We applied species distribution models (SDMs) to a species of mature forest, the northern goshawk (Accipiter gentilis, goshawk), that is often associated with hotspots of forest biodiversity. We located optimal sites for the goshawk on a landscape scale, assessed their state under intensified logging operations and identified characteristics of goshawks' nesting sites in boreal forests. Optimal sites for the goshawk covered only 3.4% of the boreal landscape and were mostly located outside pro…