Search results for "angles"

Azure C Targets and Modulates Toxic Tau Oligomers.

2018

Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder affecting millions of people worldwide. Therefore, finding effective interventions and therapies is extremely important. AD is one of over 20 different disorders known as tauopathies, characterized by the pathological aggregation and accumulation of tau, a microtubule-associated protein. Tau aggregates are heterogeneous and can be divided into two major groups: large metastable fibrils, including neurofibrillary tangles, and oligomers. The smaller, soluble and dynamic tau oligomers have been shown to be more toxic with more proficient seeding properties for the propagation of tau pathology as compared to the …

Some Applications of the Poincaré-Bendixson Theorem

2021

We consider a C 1 vector field X defined on an open subset U of the plane, with compact closure. If X has no singular points and if U is simply connected, a weak version of the Poincaré-Bendixson Theorem says that the limit sets of X in U are empty but that one can defined non empty extended limit sets contained into the boundary of U. We give an elementary proof of this result, independent of the classical Poincaré-Bendixson Theorem. A trapping triangle T based at p, for a C 1 vector field X defined on an open subset U of the plane, is a topological triangle with a corner at a point p located on the boundary ∂U and a good control of the tranversality of X along the sides. The principal app…

An improved numerical solver of the 2D diffusive shallow waters equations over unstructured triangular meshes

2009

Apolipoprotein E polymorphism is associated with both senile plaque load and Alzheimer-type neurofibrillary tangle formation.

1996

Recent work provided evidence that the apolipoprotein (apo) E polymorphism is associated with late-onset sporadic Alzheimer's disease. The major histological hallmarks of Alzheimer's disease are the extraneuronal deposition of A4/beta-amyloid and the intraneuronal formation of neurofibrillary tangles, the latter correlating strongly with the psychometric status. We examined the relationship between the apo E polymorphism and Alzheimer's disease-related histological changes using a staging system which accounts for the progression of the disease over time and correlates well with the cognitive decline ante mortem. We observed a significant positive correlation between both neurofibrillary ch…

Apolipoprotein E polymorphism influences not only cerebral senile plaque load but also Alzheimer-type neurofibrillary tangle formation.

1995

Only recently, evidence was provided that apolipoprotein E allele epsilon 4 located on Chromosome 19 is associated with late onset (i.e. senile) sporadic Alzheimer's disease. Histologically, Alzheimer's disease is associated with intraneuronal neurofibrillary changes and extraneuronal A4/beta-amyloid deposition. We set out with a histological staging system which considers the gradual development of Alzheimer's disease-related histological changes over time and correlates highly with the cognitive decline ante mortem. Our analysis revealed that both the mean stage for A4/beta-amyloid deposits and the mean stage for neurofibrillary tangles get significantly shifted upwards in epsilon 4-carri…

Simplified analytical model for moment–axial force domain in the presence of shear in R.C. members externally strengthened with steel cages

2015

Equations for a hand calculation of moment–axial force domain in the presence of shear for R.C. beam/column externally strengthened with steel angles and strips are developed. The analytical derivation is made assuming, for axial load and flexure, the equivalent stress-block parameters for internal forces, considering the confinement effects induced in the concrete core by external cages both in the cases of strips or angles yielding. Limit states due to bond failure, concrete crushing and yielding of steel angles and strips in flexure and in shear, including moment-to-shear interaction, are considered. The proposed model gives results in a good agreement with available experimental data an…

Lipofuscin Hypothesis of Alzheimer’s Disease

2011

The primary culprit responsible for Alzheimer’s disease (AD) remains unknown. Aβ protein has been identified as the main component of amyloid of senile plaques, the hallmark lesion of AD, but it is not definitively established whether the formation of extracellular Aβ deposits is the absolute harbinger of the series of pathological events that hit the brain in the course of sporadic AD. The aim of this paper is to draw attention to a relatively overlooked age-related product, lipofuscin, and advance the hypothesis that its release into the extracellular space following the death of neurons may substantially contribute to the formation of senile plaques. The presence of intraneuronal Aβ, sim…

Uncertainty evaluation in power measurements with commercial data acquisition boards

2011

The paper deals with the metrological characterization of a digital wattmeter developed by using a personal computer, a shunt, two commercial data acquisition boards and commercial software. The uncertainty of the active power measurements is assessed individually characterizing the voltage channel, the current channel and the phase displacement measurement between the two channels. In particular, the uncertainty on the voltage and current rms measurements is evaluated by using an already proposed approach based on the Monte Carlo method and on the usage of five parameters, while the uncertainty on the phase angle is experimentally estimated. In order to validate the proposed approach for t…

Dense Post-Barite-type Polymorph of PbSO4 Anglesite at High Pressures

2019

Synchrotron X-ray diffraction measurements on lead sulfate have been performed up to 67 GPa using He as pressure transmitting medium. Experiments reveal the existence of a reversible pressure-induced phase transition from the initial Pnma barite-type to the P212121 post-barite-type structure at pressures above 27 GPa. This phase transition involves a volume collapse of 2.4% and requires a considerable pressure overshoot (large pressure range with coexistence of phases) to overcome the large kinetic barrier of the transition. DFT calculations confirm the experimental observations and support the hypothesis that post-barite-type phase is the thermodynamically stable high-pressure structure fo…

The Use of Accelerometers and Gyroscopes to Estimate Hip and Knee Angles on Gait Analysis

2014

In this paper the performance of a sensor system, which has been developed to estimate hip and knee angles and the beginning of the gait phase, have been investigated. The sensor system consists of accelerometers and gyroscopes. A new algorithm was developed in order to avoid the error accumulation due to the gyroscopes drift and vibrations due to the ground contact at the beginning of the stance phase. The proposed algorithm have been tested and compared to some existing algorithms on over-ground walking trials with a commercial device for assisted gait. The results have shown the good accuracy of the angles estimation, also in high angle rate movement.