Search results for "aortic aneurysm"

showing 10 items of 255 documents

Identification of Three Particular Morphological Phenotypes in Sporadic Thoracic Aortic Aneurysm: Phenotype III As Sporadic Thoracic Aortic Aneurysm …

2014

Abstract Aging has a striking impact on the heart and the vascular system, particularly on the large elastic arteries (i.e., aorta), resulting in a multitude of changes at different structural and functional levels. As result, medial degeneration (MD) occurs. A characteristic example of MD is sporadic thoracic aortic aneurysm (S-TAA), whose patho-physiological mechanisms remain unclear. In this study, typical MD morphological phenotypes were researched in S-TAA cases and control aorta specimens by histopathological and immunohistochemical analyses. Three phenotypes (I, II, and III) were detected, but mainly the phenotype III was observed. Elevated cystic MD, plurifocal medial apoptosis, and…

MalePathologymedicine.medical_specialtyAgingThoracicAging; Aorta; Aortic Aneurysm Thoracic; Biomarkers; Female; Humans; Male; Middle Aged; PhenotypeDissection (medical)Settore MED/08 - Anatomia PatologicaThoracic aortic aneurysmAneurysmmedicine.arteryMedicineHumansSettore MED/05 - Patologia ClinicaAortaSettore MED/04 - Patologia GeneraleAortaSurgical approachAortic Aneurysm Thoracicbusiness.industrySettore MED/23 - Chirurgia CardiacaMiddle Agedmedicine.diseaseTAA phenotype IIIPhenotypeAortic AneurysmPhenotypeImmunohistochemistryBiomarker (medicine)FemaleGeriatrics and GerontologybusinessBiomarkers
researchProduct

Familial thoracic aortic aneurysm/dissection with patent ductus arteriosus: genetic arguments for a particular pathophysiological entity.

2004

International audience; Thoracic aortic aneurysm and aortic dissection (TAA and AD) are an important cause of sudden death. Familial cases could account for 20% of all cases. A genetic heterogeneity with two identified genes (FBN1 and COL3A1) and three loci (3p24-25 or MFS2/TAAD2, 5q13-q14 and 11q23.2-24) has been shown previously. Study of a single family composed of 179 members with an abnormally high occurrence of TAA/AD disease. A total of 40 subjects from three generations were investigated. In addition to five cases of stroke and three cases of sudden death, there were four cases of AD and four cases of TAA in adults. In all, 11 cases of patent ductus arteriosus (PDA) were observed, t…

MalePathologymedicine.medical_specialtycongenital hereditary and neonatal diseases and abnormalitiesGenetic Linkage030204 cardiovascular system & hematologyThoracic aortic aneurysmSudden deathFamilial thoracic aortic aneurysm03 medical and health sciencesAortic aneurysmDeath Sudden0302 clinical medicineDuctus arteriosusGenetic modelGeneticsmedicine[INFO.INFO-IM]Computer Science [cs]/Medical ImagingHumansDuctus Arteriosus PatentGenetics (clinical)030304 developmental biologyAortic dissection0303 health sciences[ INFO.INFO-IM ] Computer Science [cs]/Medical ImagingAortic Aneurysm ThoracicGenetic heterogeneitybusiness.industryAnatomymedicine.disease3. Good healthPedigreeStrokeAortic Dissectionmedicine.anatomical_structureFemaleFrancebusinessMicrosatellite RepeatsEuropean journal of human genetics : EJHG
researchProduct

Three-dimensional parametric modeling of bicuspid aortopathy and comparison with computational flow predictions

2016

Bicuspid aortic valve (BAV)-associated ascending aneurysmal aortopathy (namely “bicuspid aortopathy”) is a heterogeneous disease making surgeon predictions particularly challenging. Computational flow analysis can be used to evaluate the BAV-related hemodynamic disturbances, which likely lead to aneurysm enlargement and progression. However, the anatomic reconstruction process is time consuming so that predicting hemodynamic and structural evolution by computational modeling is unfeasible in routine clinical practice. The aim of the study was to design and develop a parametric program for three-dimensional (3D) representations of aneurysmal aorta and different BAV phenotypes starting fr…

MalePatient-Specific ModelingBicuspid aortic valveComputed Tomography AngiographyHeart Valve DiseasesBiomedical EngineeringMedicine (miscellaneous)Bioengineering—Three-dimensional anatomic reconstructionElectrocardiographyImaging Three-DimensionalBicuspid Aortic Valve DiseaseSettore ING-IND/12 - Misure Meccaniche E TermicheHumans—Finite-element analysiProspective StudiesAortaAgedRetrospective Studies—Aortic failureHemodynamicsModels CardiovascularComputational BiologySettore ING-IND/34 - Bioingegneria IndustrialeMiddle AgedBiomaterialAortic Aneurysm—Ascending thoracic aortic aneurysmAortic ValveFemaleStress MechanicalSoftware
researchProduct

Predilation technique with balloon angioplasty to facilitate percutaneous groin access of large size sheath through scar tissue

2017

Purpose Percutaneous remote access for endovascular aortic repair is an advantageous alternative to open access. Previous surgery in the femoral region and the presence of synthetic vascular grafts in the femoral/iliac arteries represent major limitations to percutaneous remote access. The aim of this study was to evaluate an original technique used for enabling percutaneous remote access for thoracic or abdominal endovascular aortic repair in patients with scar tissue and/or a vascular graft in the groin. Methods Twenty-five consecutive patients with a thoracic (11/25; 44%) or an aortic aneurysm (14/25; 66%) and with a synthetic vascular graft in the groin (16/25; 64%) or a redo groin acce…

MalePercutaneousmedicine.medical_treatment030204 cardiovascular system & hematologyBalloonEndovascular aneurysm repairSettore MED/22 - Chirurgia Vascolarecalcificationendovascular aneurysm repairAortic aneurysm0302 clinical medicinesheathprosthetic graftballoon angioplastyVascular closure device030212 general & internal medicineAged 80 and over10042 Clinic for Diagnostic and Interventional RadiologyVascular Access Deviceultrasonographyvascular closure deviceGeneral MedicineEquipment Design2746 SurgeryBlood Vessel Prosthesimedicine.anatomical_structureTreatment OutcomeFemaleRadiologyCardiology and Cardiovascular MedicineVascular Access DevicesHumanmedicine.medical_specialtycomplication610 Medicine & healthGroin2705 Cardiology and Cardiovascular MedicineAneurysm; balloon angioplasty; calcification; complications; endovascular aneurysm repair; infection; prosthetic graft; sheath; ultrasonography; vascular closure devices; Aged; Aged 80 and over; Angioplasty Balloon; Aortic Aneurysm Abdominal; Aortic Aneurysm Thoracic; Blood Vessel Prosthesis; Blood Vessel Prosthesis Implantation; Catheterization Peripheral; Cicatrix; Equipment Design; Female; Groin; Humans; Male; Treatment Outcome; Ultrasonography Interventional; Vascular Access Devices; Surgery; Radiology Nuclear Medicine and Imaging; Cardiology and Cardiovascular Medicine03 medical and health sciencesBlood Vessel Prosthesis ImplantationCicatrixBlood vessel prosthesisAngioplastyCatheterization Peripheralmedicine2741 Radiology Nuclear Medicine and ImagingHumansRadiology Nuclear Medicine and imagingUltrasonography InterventionalAgedGroinAortic Aneurysm Thoracicbusiness.industrymedicine.diseaseAneurysminfectionSurgery10020 Clinic for Cardiac SurgeryBlood Vessel ProsthesisSurgerybusinessAngioplasty BalloonAortic Aneurysm Abdominal
researchProduct

Mid- and Longer-term Follow up of Chimney and/or Periscope Grafts and Risk Factors for Failure

2016

Objective The aim was to report on chimney and periscope grafts (CPGs) and their mid- and longer-term outcomes when they are used to preserve reno-visceral artery (RVA) perfusion in endovascular repair of pararenal (PRAAs) or thoraco-abdominal aortic aneurysm (TAAAs). In addition, factors associated with CPG failure are presented. Limited data exist on the outcomes of CPGs, and mid- and long-term results are generally not reported. Methods This was a prospective study in a cohort of 100 patients with PRAA (69) or TAAA (31). A total of 224 (mean 2.24 per patient) RVAs were preserved with 136 (61%) chimney and 88 (39%) periscope grafts. CPGs were constructed mainly using self expandable stent…

MalePercutaneousmedicine.medical_treatment030204 cardiovascular system & hematologyEndovascular aneurysm repairSettore MED/22 - Chirurgia VascolareAortic aneurysm0302 clinical medicineRenal ArteryRisk FactorsOcclusion030212 general & internal medicineTreatment FailureProspective cohort studyAortaPararenal aortic aneurysm10042 Clinic for Diagnostic and Interventional RadiologyReno2746 SurgeryAortic AneurysmFemaleRadiologyCardiology and Cardiovascular Medicinemedicine.medical_specialty610 Medicine & health2705 Cardiology and Cardiovascular Medicine03 medical and health sciencesEndovascular aneurysm repairabdominal aortic aneurysmAneurysmChimney and periscope graftChimney and periscope graft; Complex aortic aneurysm; Endovascular aneurysm repair; Pararenal aortic aneurysm; Reno-visceral arteries; Thoraco-abdominal aortic aneurysm; Cardiology and Cardiovascular Medicine; SurgerymedicineHumansAgedRetrospective StudiesReno-visceral arterieThoraco-abdominal aortic aneurysmbusiness.industryComplex aortic aneurysmStentRetrospective cohort studyThoracomedicine.diseaseSurgeryvisceral arteriesSurgeryVascular GraftingbusinessFollow-Up Studies
researchProduct

Histological and genetic studies in patients with bicuspid aortic valve and ascending aorta complications.

2011

OBJECTIVES: Aneurysm diameter and growing rate does not represent a definite parameter for operation in bicuspid aortic valve (BAV), ascending aortic aneurysm and normal root patients. Thus, we investigated histological and immunohistochemical aspects of different segments of ascending aorta (precisely, aortic root without dilatation, aneurysmatic tubular portion, dissected ascending aorta) and genetic features of patients with BAV and ascending aorta complication (aneurysm or dissection). METHODS: Aorta tissue samples of 24 BAV patients were examined. The patients comprised of 18 men and 6 women; the mean age was 54.2 ± 14.3 years. All patients underwent composite aortic root replacement (…

MalePulmonary and Respiratory MedicineAortic valveGenotypeBicuspid aortic valveHeart Valve DiseasesAorta ThoracicApoptosisPolymerase Chain ReactionPolymorphism Single NucleotideAortic aneurysmAneurysmBicuspid aortic valveRisk Factorsmedicine.arteryAscending aortaIn Situ Nick-End LabelingmedicineHumansThoracic aortaSettore MED/05 - Patologia ClinicaGenetic Predisposition to DiseaseCystRetrospective StudiesAortaAortic Aneurysm Thoracicbusiness.industryDissectionSettore MED/23 - Chirurgia CardiacaFollow-up PapersDNAAnatomyMiddle Agedmedicine.diseaseImmunohistochemistryAneurysmEchocardiography Doppler ColorAortic Dissectionmedicine.anatomical_structureAortic Valvecardiovascular systemFemaleSurgeryCardiology and Cardiovascular MedicinebusinessBiomarkersEchocardiography TransesophagealFollow-Up Studies
researchProduct

Adjunct Perfusion Branch for Reduction of Spinal Cord Ischemia in the Endovascular Repair of Thoracoabdominal Aortic Aneurysms

2017

Background To analyze utilization of a perfusion branch for temporary sac perfusion to reduce the spinal cord ischemia (SCI) in the endovascular repair of thoracoabdominal aortic aneurysms (TAAAs). Methods Between January 2012 and August 2016, 30 patients (18, men; median age 72 years) were treated for TAAAs with total endovascular repair using customized branched/fenestrated endografts in our institution. The median aneurysm size was 6.6 cm. Types of TAAA were: type I, 9 (30%), type II, 5 (16.6%), type III, 4 (13.3%), type IV, 6 (20%), and type V, 6 (20%). Ten patients received a perfusion branch to create an intentional endoleak, which was occluded with vascular plugs in mean interval ti…

MalePulmonary and Respiratory Medicinemedicine.medical_specialtyMean arterial pressureTime FactorsAortographyComputed Tomography Angiography030204 cardiovascular system & hematologyAortographyBlood Vessel Prosthesis Implantation03 medical and health sciencesAortic aneurysm0302 clinical medicineAneurysmRisk FactorsHumansMedicineArterial PressureHospital MortalityAgedComputed tomography angiographyAged 80 and overAortic Aneurysm Thoracicmedicine.diagnostic_testSpinal Cord Ischemiabusiness.industryEndovascular ProceduresMiddle Agedmedicine.diseaseSurgeryPerfusionTreatment OutcomeBlood pressureSpinal CordRegional Blood FlowCardiothoracic surgeryFeasibility StudiesFemaleSurgeryCardiology and Cardiovascular MedicinebusinessPerfusion030217 neurology & neurosurgeryThe Thoracic and Cardiovascular Surgeon
researchProduct

Endovascular treatment of large and wide aortic neck: case report and literature review

2017

Large (24–34 mm) and wide (≥35 mm) aortic necks are a contraindication to endovascular aneurysm repair (EVAR). A 63-year-old man, unfit for conventional surgery, presented a 79 mm abdominal aortic aneurysm with 36.5 mm aortic neck and a 62 mm right common iliac artery aneurysm. He was treated endovascularly with standard commercially available stent-graft using the so-called ‘funnel technique’; by placing a thoracic stent-graft inside a bifurcated device to achieve proximal sealing. The completion angiography and the 6 months follow-up with computed tomography showed no stent-graft migration, limb occlusion or endoleak. The literature review reported 179 cases of large aortic neck managed w…

MalePulmonary and Respiratory Medicinemedicine.medical_specialtyTime FactorsEndoleakTime Factormedicine.medical_treatmentRight Common Iliac Artery030204 cardiovascular system & hematologyEndovascular aneurysm repairSettore MED/22 - Chirurgia Vascolare030218 nuclear medicine & medical imaging03 medical and health sciencesBlood Vessel Prosthesis Implantation0302 clinical medicineAneurysmOcclusionmedicineStentHumanscardiovascular diseasesComplications; Endoleak; Funnel technique; Large neck; Migration; Aortic Aneurysm Abdominal; Blood Vessel Prosthesis Implantation; Endovascular Procedures; Humans; Male; Middle Aged; Time Factors; Tomography X-Ray Computed; Stents; Surgery; Pulmonary and Respiratory Medicine; Cardiology and Cardiovascular MedicineContraindicationMigrationEndovascular Proceduremedicine.diagnostic_testLarge neckbusiness.industryEndovascular ProceduresGeneral MedicineMiddle Agedmedicine.diseaseAbdominal aortic aneurysmSurgerysurgical procedures operativeAngiographycardiovascular systemStentsSurgeryAortic neckbusinessFunnel techniqueTomography X-Ray ComputedCardiology and Cardiovascular MedicineComplicationAortic Aneurysm AbdominalHuman
researchProduct

Outcome after surgery for acute aortic dissection type A in patients over 70 years: data analysis from the German Registry for Acute Aortic Dissectio…

2010

Objective: The number of elderly patients undergoing emergency surgery for acute aortic dissection type A (AADA) is rising. Published results report a higher risk for thesepatients comparedwith younger patients. The aim of our study wasto analyse the surgicaloutcomeof these patients and to identify those at risk. Methods: Between July 2006 and June 2009, 44 centres participating in the German Registry for Acute Aortic Dissection Type A (GERAADA) reported a total of 1558 patients. As many as 381 patients were between 70 and 80 years of age (septuagenarians), while 83 patients were 80 years and older (octogenarians). We compared the clinical features and events occurring 30 days after surgery…

MalePulmonary and Respiratory Medicinemedicine.medical_specialtylaw.inventionBlood Vessel Prosthesis ImplantationAortic aneurysmAneurysmlawGermanyCardiac tamponademedicineHumansIn patientRegistriesAgedAged 80 and overAortic dissectionbusiness.industryPatient SelectionAge FactorsGeneral MedicineOdds ratiomedicine.diseaseIntensive care unitConfidence intervalAortic AneurysmSurgeryAortic DissectionTreatment OutcomeAcute DiseaseFemaleSurgeryEmergenciesCardiology and Cardiovascular MedicinebusinessEuropean Journal of Cardio-Thoracic Surgery
researchProduct

Mortality in patients with acute aortic dissection type A: analysis of pre- and intraoperative risk factors from the German Registry for Acute Aortic…

2015

Acute aortic dissection type A (AADA) is an emergency with excessive mortality if surgery is delayed. Knowledge about independent predictors of mortality on surgically treated AADA patients is scarce. Therefore, this study was conducted to identify pre- and intraoperative risk factors for death.Between July 2006 and June 2010, 2137 surgically treated patients with AADA were enrolled in a multicentre, prospective German Registry for Acute Aortic Dissection type A (GERAADA), presenting perioperative status, operative strategies, postoperative outcomes and AADA-related risk factors for death. Multiple logistic regression analysis was performed to identify the influence of different parameters …

MalePulmonary and Respiratory Medicinemedicine.medical_specialtymedicine.medical_treatmentOperative TimeMyocardial IschemiaIschemiaDisease030204 cardiovascular system & hematologyBrain Ischemia03 medical and health sciences0302 clinical medicineIschemiaRisk FactorsGermanymedicine.arteryHumansMedicineProspective StudiesRegistriesCardiopulmonary resuscitationIntraoperative ComplicationsAortic dissectionLegAortaAortic Aneurysm Thoracicbusiness.industryGeneral MedicineOdds ratioPerioperativeMiddle Agedmedicine.diseaseSurgeryAortic DissectionTreatment OutcomeHemiparesis030228 respiratory systemAcute DiseaseFemaleSurgerymedicine.symptomCardiology and Cardiovascular MedicinebusinessAortic Aneurysm AbdominalEuropean Journal of Cardio-Thoracic Surgery
researchProduct