Search results for "arco"
showing 10 items of 1716 documents
Folate-targeted gold nanorods for effective combined photothermal-chemotherapy of osteosarcoma
2016
Osteosarcoma (OS) is the most common primary malignant neoplasm of bone. The annual incidence of osteosarcoma is 8-11 per million in the age group of 15-19 years. Despite its rarity, it has been reported to be the second leading cause of cancer-related deaths in children and young adults. In particular with regard to OS therapy, a variety of nanostructures have been exploited in the areas of OS imaging. Among them, Gold nanorods (AuNRs) have unique optical and chemical-physical properties that make them appealing for biomedical applications such as photothermal therapy, drug delivery and imaging of solid tumors. The noble metal core is biologically inert, contributing to low toxicity and go…
NIR LASER-RESPONSIVE FOLATE-TARGETED GOLD NANORODS AS EFFICIENT THERANOSTIC TOOL FOR OSTEOSARCOMA TREATMENT
2017
Folate-targeted gold nanorods (GNRs) are here proposed as selective theranostic agents for osteosarcoma treatment. Taking advantage of the attractive physiochemical and optical properties of GNRs they can be proposed as effective and selective platform to obtain a targeted intracellular drug release, photothermal therapy and cancer imaging, which may improve therapeutic outcomes of osteosarcoma. An amphiphilic polysaccharide graft-copolymer, named INU-LA-PEG-FA, and a folic acid functionalized α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide (PHEA-FA), have been synthesized to act as coating agents for GNRs. The obtained polymer-coated GNRs were characterized in terms of size, shape, zeta potenti…
Deepening Inside the Pictorial Layers of Etruscan Sarcophagus of Hasti Afunei: An Innovative Micro-Sampling Technique for Raman/SERS Analyses
2019
The Hasti Afunei sarcophagus is a large Etruscan urn, made up of two chalky alabaster monoliths. Dated from the last quarter of the third century BC, it was found in 1826 in the small town of Chiusi (Tuscany- Il Colle place) by a landowner, Pietro Bonci Casuccini, who made it part of his private collection. The noble owner&rsquo
Polysarcosine-Based Lipids: From Lipopolypeptoid Micelles to Stealth-Like Lipids in Langmuir Blodgett Monolayers.
2016
Amphiphiles and, in particular, PEGylated lipids or alkyl ethers represent an important class of non-ionic surfactants and have become key ingredients for long-circulating (“stealth”) liposomes. While poly-(ethylene glycol) (PEG) can be considered the gold standard for stealth-like materials, it is known to be neither a bio-based nor biodegradable material. In contrast to PEG, polysarcosine (PSar) is based on the endogenous amino acid sarcosine (N-methylated glycine), but has also demonstrated stealth-like properties in vitro, as well as in vivo. In this respect, we report on the synthesis and characterization of polysarcosine based lipids with C14 and C18 hydrocarbon chains and their end g…
À bas la sélection ! Misère de la critique
2019
International audience; La critique de la sélection à l'entrée de l'université repose sur une vision misérabiliste des étudiants de milieu populaire et ne remet pas en question les inégalités au sein du système d'éducation. Il existe sans doute mille bonnes raisons d'être hostile à Parcoursup et à la réforme du baccalauréat, comme il existe de solides raisons de protester contre les conditions de travail des professeurs, des enseignants-chercheurs et des étudiants… Le propos de ce texte n'est pas de participer aux débats sur le bien-fondé des réformes ; il n'est ni de les défendre ni de les contester, mais d'interroger les cadres de la critique de la sélection que ces réformes sont censées …
Effects of pyrolysis temperature on the hydrologically relevant porosity of willow biochar
2018
Biochar pore space consists of porosity of multiple length scales. In direct water holding applications like water storage for plant water uptake, the main interest is in micrometre-range porosity since these pores are able to store water that is easily available for plants. Gas adsorption measurements which are commonly used to characterize the physical pore structure of biochars are not able to quantify this pore-size range. While pyrogenetic porosity (i.e. pores formed during pyrolysis process) tends to increase with elevated process temperature, it is uncertain whether this change affects the pore space capable to store plant available water. In this study, we characterized biochar poro…
El Trabajo penitenciario: ¿De qué partimos y hacia dónde nos dirigimos?
2017
Estructura Competencial y de utilización de las TIC y su relación con las variables personales y contextuales clave en el profesorado no universitario
2022
La Sociedad del Conocimiento supone nuevas competencias que ha de fomentar el sistema educativo. El profesorado, como actor principal de la integración de las TIC en el aula, ha de adquirir y dominar las Competencias TIC de forma que prepare al alumnado en la cultura digital. El objetivo de este trabajo consiste en determinar la dimensionalidad y la relación estructural de las competencias TIC (tecnológicas, pedagógicas y éticas) que posee el profesorado de Educación Primaria y Educación Secundaria de la Comunidad Valenciana, junto con la incidencia de los factores personales y contextuales sobre tal estructura. Se ha empleado un diseño correlacional, con una muestra compuesta por 1.002 pro…
Le “verdi” Olimpiadi di Sydney – L’applicazione del concetto di sostenibilità ambientale nella progettazione dei siti e nella gestione dei giochi oli…
2001
Nuove relazioni tra tessuto urbano e agricolo nel parco del Gugliotta a piano tavola Carini. progetto.
2014
Il tema fondamentale del progetto è il ridisegno dei collegamenti e delle connessioni fra le aree abitate ed agricole. Ai tracciati esistenti viene assegnata una nuova dimensione, proporzionata ai nuovi percorsi pedonali e carrabili ed alle essenze che ne definiscono i limiti e le soglie. I nuovi tracciati carrabili definiscono meglio i collegamenti fra le varie aree e rendono facilmente raggiungibili i nuovi servizi che offre l’area, principalmente il sistema delle scuole, la nuova piazza del mercato, ed il parcheggio semi interrato che si dispone ai lati della via A. Da Messina. Il percorso ciclopedonale, che si sviluppa tra Monte Pecoraro e Monte Colombrina, seguendo il tracciato dell’ac…