Search results for "arki"

showing 10 items of 1015 documents

The Role of Recollection and Familiarity in Nondemented Parkinson's Patients

2017

The aim of the current study was to examine if recollection and familiarity decline in nondemented Parkinson's patients. To do so we compared a sample of older people with Parkinson's disease (n = 32) to a control sample of healthy older people (n = 32) on an associative recognition task in which we manipulated the repetition of the pairs during the study phase (half of the pairs were presented once and half twice) to obtain corrected estimates of recollection, familiarity, and false recognition based on the logic of the process-dissociation procedure. The results clearly show that recollection is impaired but familiarity is preserved in nondemented Parkinson's patients. The results show th…

MaleStudy phaseParkinson's diseaseExperimental and Cognitive PsychologyNeuropsychological Tests050105 experimental psychologyGender Studies03 medical and health sciences0302 clinical medicineArts and Humanities (miscellaneous)medicineHumans0501 psychology and cognitive sciencesControl sampleAgedAged 80 and overRecall05 social sciencesParkinson DiseaseRecognition PsychologyMiddle Agedmedicine.diseaseFalse recognitionMental RecallFemaleOlder peoplePsychology030217 neurology & neurosurgeryCognitive psychologyThe Journal of General Psychology
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High-frequency rTMS improves time perception in Parkinson disease.

2004

Patients with Parkinson disease (PD) are impaired in time processing. The authors investigated the effects of high-frequency (5 Hz) repetitive transcranial magnetic stimulation (rTMS) in patients with PD performing a time reproduction task. The authors found significant improvement in time processing induced by rTMS when trains were applied over the right dorsolateral prefrontal cortex (DLPFC) but not over the supplementary motor area, suggesting that the circuit involving the basal ganglia and the DLPFC might constitute the neural network subserving time perception.

MaleTRANSCRANIAL MAGNETIC STIMULATIONCORTEXmedicine.medical_treatmentmedia_common.quotation_subjectFrontal Lobe; Magnetics; Parkinson Disease; Humans; Treatment Outcome; Aged; Time Perception; Middle Aged; Prefrontal Cortex; Perceptual Disorders; Male; FemalePrefrontal CortexDiseasebehavioral disciplines and activitiesNOCentral nervous system diseasePerceptual DisordersMagneticsDegenerative diseasePerceptionmental disordersBasal gangliamedicineHumansmedia_commonAgedSupplementary motor areaSettore M-PSI/02 - Psicobiologia E Psicologia FisiologicaParkinson DiseaseTime perceptionMiddle Agedmedicine.diseaseFrontal LobeTranscranial magnetic stimulationmedicine.anatomical_structureTreatment Outcomenervous systemTime PerceptionSettore MED/26 - NeurologiaFemaleNeurology (clinical)PsychologyNeurosciencepsychological phenomena and processesNeurology
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Prevalence of fatigue in Parkinson disease and its clinical correlates

2014

Objective: To assess in a noninterventional setting the prevalence and severity of fatigue in patients with Parkinson disease (PD). Methods: This was a cross-sectional study conducted in Italian patients with PD. Objectives included the evaluation of the current prevalence and severity of fatigue in patients with PD measured using the 16-item Parkinson Fatigue Scale (PFS-16), distressing fatigue (defined as a PFS-16 mean score $3.3), and assessment of its clinical correlates. Results: A total of 402 patients were enrolled and 394 patients completed the PFS-16 questionnaire with a PFS-16 mean (6SD) score of 2.87 6 0.99. Of these, 136 patients (33.8%) reported distressing fatigue (PFS-16 mean…

MaleTime FactorsDiseaseDSM-IV 5 Diagnostic and Statistical Manual of Mental Disorders 4th edition; ICD-10 5 International Classification of Diseases 10th revision; MAO-B 5 monoamine oxidase B; MS 5 multiple sclerosis; PD 5 Parkinson disease; PDQ-39 5 39-item Parkinson’s Disease Questionnaire; PDSS 5 Parkinson’s Disease Sleep Scale; PFS-16 5 16-item Parkinson Fatigue Scale; UPDRS 5 Unified Parkinson’s Disease Rating ScaleSeverity of Illness IndexQuality of life80 and overPrevalencePDSS 5 Parkinson’s Disease Sleep ScaleAge FactorDepression (differential diagnoses)FatigueAged 80 and overDepressionmusculoskeletal neural and ocular physiologyAge FactorsParkinson DiseasePDQ-39 5 39-item Parkinson’s Disease QuestionnaireMiddle AgedItalyPFS-16 5 16-item Parkinson Fatigue ScaleFemaleSettore MED/26 - NeurologiaMS 5 multiple sclerosiPsychologyHumanAdultSleep Wake Disordersmedicine.medical_specialtyPD 5 Parkinson diseasemacromolecular substancesArts and Humanities (miscellaneous)Internal medicinemedicineDistressingHumansIn patientAgedCross-Sectional StudieMAO-B 5 monoamine oxidase BUPDRS 5 Unified Parkinson’s Disease Rating Scalenervous system diseasesAdult; Age Factors; Aged; Aged 80 and over; Cross-Sectional Studies; Depression; Fatigue; Female; Humans; Italy; Male; Middle Aged; Parkinson Disease; Prevalence; Severity of Illness Index; Sleep Wake Disorders; Time Factors; Neurology (clinical); Arts and Humanities (miscellaneous)Cross-Sectional Studiesnervous systemICD-10 5 International Classification of Diseases 10th revisionPhysical therapyNeurology (clinical)DSM-IV 5 Diagnostic and Statistical Manual of Mental Disorders 4th editionSleep Disorder
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Autobiographical memory in Parkinson's disease: A retrieval deficit

2012

This study examined the effects of providing cues to facilitate autobiographical memory retrieval in Parkinson's disease. Previous findings have shown that individuals with Parkinson's disease retrieve fewer specific autobiographical memories than older adult controls. These findings are clinically significant since the quality of autobiographical memory is linked to identity and sense of self. In the current study, 16 older adults with Parkinson's disease without dementia and 16 matched older adult controls were given 3 min in which to recall autobiographical memories associated with five different time periods and to give each memory a short title. Participants were later asked to retriev…

MaleTime FactorsParkinson's diseaseRecallAutobiographical memoryMemory EpisodicCognitive NeuroscienceNeuropsychologyParkinson Diseasemedicine.diseaseBehavioral NeuroscienceNeuropsychology and Physiological PsychologyFree recallCase-Control StudiesMental RecallmedicineHumansDementiaFemaleChildhood memoryCuesPsychologyEpisodic memoryAgedCognitive psychologyJournal of Neuropsychology
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Impaired reproduction of second but not millisecond time intervals in Parkinson's disease

2008

The basal ganglia have been associated with temporal processing in ranges of milliseconds and seconds. However, results from PD patient studies are elusive. Time perception in these patients has been tested with different approaches including repetitive movement tasks (i.e. finger tapping) and cognitive tasks (i.e. time reproduction), and both abnormal and normal performances have been reported for different time intervals. Furthermore, when PD patients were required to learn two target durations in the same session when they were off medication, they overestimated the short duration and underestimated the long duration in the seconds range. This pattern of temporal accuracy was described a…

MaleTime perception; Parkinson's disease; Basal ganglia; Dopamine; MemoryParkinson's diseaseDopamineNeuropsychological TestsAudiologyBehavioral neuroscienceAntiparkinson AgentsBehavioral NeuroscienceCognitionAttentionBRAINTomographyDepression; Humans; Tomography X-Ray Computed; Time Perception; Aged; Antiparkinson Agents; Memory Disorders; Cognition; Psychiatric Status Rating Scales; Parkinson Disease; Psychomotor Performance; Middle Aged; Neuropsychological Tests; Attention; Female; Male; Reaction TimeMillisecondDepressionParkinson DiseaseCognitionPsychiatric Status Rating ScaleMiddle AgedTime perceptionTIMEX-Ray ComputedNeuropsychology and Physiological PsychologyAntiparkinson AgentBasal gangliaNeuropsychological TestFemaleSettore MED/26 - NeurologiaPsychologyHumanMemory Disordermedicine.medical_specialtyElementary cognitive taskCognitive NeuroscienceExperimental and Cognitive PsychologyCognitive neuroscienceNOMemoryReaction TimemedicineHumansAgedPsychiatric Status Rating ScalesMemory DisordersSettore M-PSI/02 - Psicobiologia E Psicologia FisiologicaMemoriaTime PerceptionFinger tappingTomography X-Ray ComputedPARKINSONNeurosciencePsychomotor PerformanceNeuropsychologia
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Acute inactivation of the medial forebrain bundle imposes oscillations in the SNr: a challenge for the 6-OHDA model?

2010

It has been recently shown that the substantia nigra pars reticulata (SNr) of 6-hydroxydopamine (6-OHDA)-lesioned rats, under urethane anaesthesia, manifests a prominent low frequency oscillation (LFO) of around 1Hz, synchronized with cortical slow wave activity (SWA). Nevertheless, it is poorly understood whether these electrophysiological alterations are correlated only with severe dopamine depletion or may also play a relevant pathogenetic role in the early stages of the dopamine denervation. Hence, here we recorded SNr single units and electrocorticogram (ECoG) in two models of dopamine denervation: (i) acute dopamine denervated rats, obtained by injection of tetrodotoxin (TTX), (ii) ch…

MaleTyrosine 3-Monooxygenasebasal ganglia oscillationsDopamineParkinson's diseaseWistarAction PotentialsParkinson's disease; Low frequency oscillation basal ganglia oscillations; Medial forebrain bundle; Tetrodotoxin; ElectrocorticogramTetrodotoxinSettore BIO/09 - FisiologiaParkinson's disease; low frequency oscillation; basal ganglia oscillations; medial forebrain bundle; Tetrodotoxin; electrocorticogramStatistics NonparametricAnimals; Analysis of Variance; Action Potentials; Electrophysiology; Tyrosine 3-Monooxygenase; Cerebral Cortex; Rats; Biological Clocks; Dopamine; Neurons; Rats Wistar; Substantia Nigra; Immunohistochemistry; Medial Forebrain Bundle; Statistics Nonparametric; MaleMedial forebrain bundlechemistry.chemical_compoundDevelopmental NeuroscienceBiological ClocksDopamineBasal gangliamedicineAnimalsNonparametricRats WistarMedial forebrain bundleElectrocorticographyCerebral CortexNeuronsDenervationAnalysis of Variancemedicine.diagnostic_testChemistryStatisticsLow frequency oscillation basal ganglia oscillationElectrocorticogramImmunohistochemistryRatsCortex (botany)ElectrophysiologySubstantia NigraElectrophysiologynervous systemNeurologylow frequency oscillationTetrodotoxinSettore MED/26 - NeurologiaNeurosciencemedicine.drug
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Neurofunctional correlates of attention rehabilitation in Parkinson's disease: an explorative study

2014

The effectiveness of cognitive rehabilitation (CR) in Parkinson’s disease (PD) is in its relative infancy, and nowadays there is insufficient information to support evidence-based clinical protocols. This study is aimed at testing a validated therapeutic strategy characterized by intensive computer-based attention-training program tailored to attention deficits. We further investigated the presence of synaptic plasticity by means of functional magnetic resonance imaging (fMRI). Using a randomized controlled study, we enrolled eight PD patients who underwent a CR program (Experimental group) and seven clinically/demographically-matched PD patients who underwent a placebo intervention (Contro…

Malemedicine.medical_specialtyBrain activity and meditationPrefrontal CortexDermatologyNeuropsychological TestsStatistical parametric mappingPhysical medicine and rehabilitationParietal LobemedicineHumansAttentionSingle-Blind MethodEffects of sleep deprivation on cognitive performanceCognitive rehabilitation therapyPrincipal Component AnalysisNeuronal PlasticityResting state fMRImedicine.diagnostic_testCognitionParkinson DiseaseGeneral MedicineMiddle AgedMagnetic Resonance ImagingDorsolateral prefrontal cortexPsychiatry and Mental healthParkinson disease rehabilitationmedicine.anatomical_structureMemory Short-TermPhenotypeSpace PerceptionTherapy Computer-AssistedVisual PerceptionFemaleSettore MED/26 - NeurologiaNeurology (clinical)Nerve NetFunctional magnetic resonance imagingPsychologyCognition DisordersNeurosciencePsychomotor Performance
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Is there still a role for lesioning in functional neurosurgery? Preliminary Italian (and world-first) experience with a trans-cranial MRI-guided focu…

2015

Malemedicine.medical_specialtyDeep Brain StimulationEssential TremorFunctional neurosurgeryNeurosurgical Procedures030218 nuclear medicine & medical imaging03 medical and health sciences0302 clinical medicinemedicineHumansUltrasonographybusiness.industryBrainParkinson DiseaseMiddle AgedFocused ultrasound surgeryMagnetic Resonance ImagingItalySurgery Computer-AssistedSurgeryNeurology (clinical)RadiologyTomography X-Ray Computedbusiness030217 neurology & neurosurgeryMri guidedJournal of Neurosurgical Sciences
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Increased neuropeptide Y mRNA expression in striatum in Parkinson's disease.

2003

High levels of neuropeptide Y (NPY) are found in basal ganglia where it is co-localised with somatostatin (SOM) and nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH/d) in a population of striatal GABA containing interneurones. Although alterations occur in the levels of various neuropeptides in basal ganglia in Parkinson’s disease (PD), it is not known whether NPY is affected. Using in situ hybridisation immunohistochemistry, we have examined the distribution of NPY mRNA in the caudate nucleus, putamen and nucleus accumbens of normal individuals and patients with PD. NPY mRNA was weakly expressed in the caudate nucleus, putamen and nucleus accumbens in normal individuals with a…

Malemedicine.medical_specialtyIn situ hybridisationPopulationCaudate nucleusNeuropeptideStriatumBiologyNucleus accumbensNucleus AccumbensStriatumCellular and Molecular NeuroscienceNeuropeptide Y (NPY)InterneuronsInternal medicinemental disordersBasal gangliamedicineHumansNeuropeptide YRNA MessengereducationMolecular BiologyAgededucation.field_of_studyPutamenPutamenParkinson DiseaseMiddle AgedNeuropeptide Y receptorhumanitiesCorpus StriatumEndocrinologynervous systemGene Expression RegulationParkinson’s diseaseSettore BIO/14 - FarmacologiaFemaleCaudate NucleusBrain research. Molecular brain research
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Is Transcranial Magnetic Resonance Imaging-Guided Focused Ultrasound a Repeatable Treatment Option? Case Report of a Retreated Patient With Tremor Co…

2019

Introduction In recent years, transcranial Magnetic Resonance Imaging-guided Focused Ultrasound (tcMRgFUS) treatments for functional neurological disorders are giving a new thrust to the field of therapeutic brain lesioning. Objective To present the case of a patient affected by tremor combined with Parkinsonism who underwent a second tcMRgFUS thalamotomy because of relapsing tremor after a few months from the first tcMRgFUS treatment. Methods A 72-yr-old, right-handed man, came to our observation because of a disabling tremor affecting his upper limbs, refusing any invasive surgical procedure and already treated by tcMRgFUS left Vim thalamotomy. However, clinical benefit had brief duration…

Malemedicine.medical_specialtyInterventional magnetic resonance imagingmedicine.medical_treatmentEssential TremorFocused ultrasoundParkinsonian DisordersTremorMedicineHumansAgedmedicine.diagnostic_testbusiness.industryPatient affectedThalamotomySettore MED/27 - NeurochirurgiaParkinsonismSettore FIS/01 - Fisica SperimentaleTreatment optionsSettore MED/37 - NeuroradiologiaMagnetic resonance imagingmedicine.diseaseMagnetic Resonance ImagingTreatment OutcomeStereotaxic techniqueSurgerySettore MED/26 - NeurologiaNeurology (clinical)RadiologyHigh-intensity focused ultrasound ablation Minimally invasive surgical procedures Stereo- taxic techniques Tremor Parkinsonian disorders Interventional magnetic resonance imaging Intraoperative monitoringbusinessSettore MED/36 - Diagnostica Per Immagini E Radioterapia
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