Search results for "arki"

Resveratrol increases DAT expression levels in the striatum of female mouse and its effect is mediated by estrogen receptors

2010

Resveratrol (3,4',5-trihydroxystilbene, RSV), a phytoalexins with a stilbene skeleton, exhibits a wide range of biological actions that includes neuroprotective effect against neurodegenerative diseases. In a previous study on RSV neuroprotective effects in mouse Parkinson’s model, we unexpectedly observed an upregulation of DAT in the striatum of female mice treated with RSV. Here we aimed to study in depth the effect of RSV on DAT expression, and additionally to verify the potential involvement of estrogen receptor activation by RSV, according with its striking similarity to the synthetic estrogen diethylstilbestrol. Daily repeated injection of RSV (20 mg/kg i.p.) for four days led, eight…

Buccal delivery as a new challenge for treatment of motor fluctuations in Parkinson's Disease

2011

Effects of Grade Retention Policies: A Literature Review of Empirical Studies Applying Causal Inference

2021

The identification of the causal effects of grade retention policies is of enormous relevance for researchers and policymakers alike. Taking advantage of the availability of more detailed longitudinal datasets, researchers have been able to apply different identification strategies that address the classical problems of selection bias and unobserved heterogeneity that have plagued previous studies on the effect of retention. We present a systematic literature review of empirical studies aiming to unveil the causal effects of retention. This study underlines the need to consider and evaluate different kinds of grade retention polices as their effects vary depending on several dimensions (suc…

Chemical intervention in senescence-accelerated mice metabolism for modeling neurodegenerative diseases: an overview

2004

Abstract SAMP1 is a line of inbred mice with a pronounced misbalance between generation and neutralization of reactive oxygen species (ROS) in brain and other tissues. This results in accumulation of molecular defects in lipids, proteins and DNA moieties. The metabolic disorders appear at a very early stage of ontogenic development and induce morphological and behavioral defects manifesting from the fourth month after birth. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment of these mice induced specific changes that closely resembled parkinsonian syndrome. Neuropeptide carnosine prevented toxic effects of MPTP and protected the animals against experimental parkinsonism.

A Survey of Methods to Interpolate, Distribute and Extra- polate Time Series

2010

This survey provides an overview with a broad coverage of the literature on methods for temporal disaggregation and benchmarking. Dozens of methods, procedures and algorithms have been proposed in the statistical and economic literature to solve the problem of transforming a low-frequency series into a high-frequency one. This paper classifies and reviews the procedures, provides interesting discussion on the history of the methodological development in this literature and permits to identify the assets and drawbacks of each method, to comprehend the current state of art on the subject and to identify the topics in need of further development. It would be useful for readers who are interest…

Parking Pricing for a Sustainable Transport System

2014

Abstract The purpose of this study has been the develop of a model for designing an efficient parking pricing policy. The aim is an intelligent control and management system of parking pricing integrated with a redefinition of the circulation scheme for a limited traffic zone in the Central Business District (CBD) of Palermo. The transport demand over the entire area of the town has been studied in order to design various parking pricing scenarios with the application of an additional cost on parking inside the selected area of the CBD. This area attracts most of the private vehicular traffic and it is characterized by university faculties, schools, hospitals, offices and commercial areas. …

Fuzzy ServPerf model combined with ELECTRE III to comparatively evaluate service quality of international airports in Sicily

2015

In this paper a new approach was proposed so as to comparatively evaluate the quality of service alternatives. In particular, a fuzzy extension of the ServPerf service conceptual model was considered to estimate quality scores of fundamental service criteria, whereas the non-compensative multi-criteria decision-making ELECTRE III method was employed to point out the quality ranking of service alternatives on the basis of which the comparative service quality analysis was performed. In order to show the effectiveness of the proposed approach, an empirical study concerning service quality evaluation of the three international airports in Sicily (Italy) was conducted with detailed proposals fo…

Evolving e-government benchmarking to better cover technology development and emerging societal needs

2012

Many international e-government benchmarks seek to measure progress towards various versions of a digital society, and in this endeavor include a component of e-government. But because comparable international e-government data are scarce, most reports rely on the United Nations E-Government Development Index, specifically its Online Service Index as a benchmark. However, this assessment only captures national level initiatives at a broad level and does not link evaluation to outcomes and impacts, i.e. e-government performance relative to investment.This paper briefly reviews the current UN framework and assesses how it can evolve to meet new demands, such as calls to better connect investm…

A Simulation Analysis for Assessing the Reliability of AC/DC Hybrid Microgrids - Part I: Underground Station and Car Parking

2021

This paper reports the results of a simulation study with the aim of evaluating the capability of two portions of a hybrid AC/DC MV/LV network of maintaining their operation in off-grid mode during the loss of the main AC grid due to a failure. In particular, the study aims to verify, in the case of islanded operation of the two microgrids, the continuity of the electricity service by exploiting the local generation plants, Energy Storage Systems (ESSs), and other flexible resources managed by suitable algorithms in different energy scenarios. The analysis was carried out considering two microgrids: an underground station and a car parking with Electric Vehicles (EVs). For assessing the per…

Accounting for service quality to customers in the efficiency of water companies: evidence from England and Wales

2015

This paper investigates the role of service quality to customers in the efficiency assessment of water companies in England and Wales. To achieve this, data envelopment analysis techniques are employed to compute the technical efficiency of the water companies following two approaches: (i) traditional assessment based on quantity variables (without the inclusion of service quality variables) and (ii) alternative assessment considering quantity and service quality variables as undesirable outputs. The analysis covers 22 water and sewerage companies and water only companies providing drinking water services. The results indicate that the traditional efficiency assessment reveals a high level …