Search results for "arki"

Characteristics of Bipolar Patients with Cognitive Impairment of Suspected Neurodegenerative Origin: A Multicenter Cohort

2021

Bipolar disorder is associated with an increased risk of dementia with aging. Little is known regarding this association, limiting appropriate diagnosis and management. We aimed to describe the characteristics of bipolar patients with late cognitive impairment for whom the hypothesis of an underlying neurodegenerative disease had been raised. We performed a retrospective multicenter study, recruiting bipolar patients over 50 years old from five French tertiary memory centers who had undergone cerebrospinal fluid (CSF) biomarker assessment for Alzheimer’s disease (AD). Clinical, neuropsychological, and paraclinical characteristics were analyzed and 78 patients were included. The mean age at …

Frequency of cognitive impairment and factors associated in outpatients with Parkinson’s disease

2011

Preservation in Disaster Situations: a case study of the Valvilla Wool Mill Museum, Finland

2013

This article discusses the role of documentation and rescue planning in minimizing collection damages in disaster situations. The topic is surveyed through a case study of a fire that occurred in 2003 at the Valvilla Wool Mill museum in Hyvinkää, in Southern Finland. This incident caused significant damage to the authenticity and integrity of the museum’s archival collection. Both the fire and the extinguishing of the fire caused severe damage to items in the archival collection. Deterioration continued during aftercare, causing serious secondary collection damage because the methods of the first aid and aftercare were spontaneously planned and applied. By using the Valvilla Wool Mill museu…

Fabry Disease With Concomitant Lewy Body Disease

2019

AbstractAlthough Gaucher disease can be accompanied by Lewy pathology (LP) and extrapyramidal symptoms, it is unknown if LP exists in Fabry disease (FD), another progressive multisystem lysosomal storage disorder. We aimed to elucidate the distribution patterns of FD-related inclusions and LP in the brain of a 58-year-old cognitively unimpaired male FD patient suffering from predominant hypokinesia. Immunohistochemistry (CD77, α-synuclein, collagen IV) and neuropathological staging were performed on 100-µm sections. Tissue from the enteric or peripheral nervous system was unavailable. As controls, a second cognitively unimpaired 50-year-old male FD patient without LP or motor symptoms and 3…

Computer-assisted cognitive remediation for Parkinson’s disease

2012

Improving Docking Performance Using Negative Image-Based Rescoring

2018

Despite the large computational costs of molecular docking, the default scoring functions are often unable to recognize the active hits from the inactive molecules in large-scale virtual screening experiments. Thus, even though a correct binding pose might be sampled during the docking, the active compound or its biologically relevant pose is not necessarily given high enough score to arouse the attention. Various rescoring and post-processing approaches have emerged for improving the docking performance. Here, it is shown that the very early enrichment (number of actives scored higher than 1% of the highest ranked decoys) can be improved on average 2.5-fold or even 8.7-fold by comparing th…

Measurement of Open Access as an Infrastructural Challenge : The Case of Finland

2017

Finland has set numeric goals for the development of open access. However, at the moment, no system is available by which this development could be monitored. Poor quality in the metadata records in universities’ research information databases prevents metadata-based analysis of open access publishing progress. This paper shows how the quality problems of Finnish publication data can be resolved through centralizing the services and processes of metadata creation and by improving the interoperability of systems involved in the processes. As a result, this study describes an environment where reliable measurement of open access is possible and presents suggested actions for improving the Fin…

Vadlīnijas dendroloģisko parku turpmākai attīstībai

2018

Maģistra darbā ir izstrādātas vadlīnijas dendroloģisko vērtīgo parku plānošanai. Darbā ir apskatīti 15 dendroloģiski vērtīgi parki un detāli ir analizēti seši aizsargājami dendroloģiskie dendroloģiski vērtīgi parki. Darbā norādīts, ka daudzi no dendroloģiski vērtīgiem parkiem, pašreiz netiek apsaimniekoti, tajos nav atbilstošu dendroloģisko vērtību un tie vairs neatbilst aizsargājamas teritorijas statusam. Balstoties uz darbā veikto izpēti, tai skaitā apsekojot parkus dabā, darbā ir dots priekšlikums diviem dendroloģiski vērtīgo parku plānošanas un attīstības virzieniem, padarot kopējo sistēmu pēc iespējas saprotamāku. Atslēgas vārdi: dendroloģiskie stādījumi, cilvēku veidoti dendroloģiski …

Suurikokoisten kulttuurihistoriallisten arkkitehtuuripiirustuksien digitointi

2001

The role of small local history museums in creating digital heritage : the Finnish case

2017

The overall objective of this museological research is to investigate the role of small Finnish local heritage museums in creating digital heritage. The research aims are: (1) to provide a critical overview of virtual museums and digital heritage in the Finnish context, particularly in relation to small local history museums; (2) to bring attention to the potential of small museums in the area of digital heritage, and (3) to provide an insight into the shared qualities of digital heritage in small museums in Finland that can be used in future projects in the area of digital heritage in Finland. The research examines the following questions: (1) What are the qualities of the online services …