Search results for "asd"

New progress of high current gasdynamic ion source (invited).

2016

The experimental and theoretical research carried out at the Institute of Applied Physics resulted in development of a new type of electron cyclotron resonance ion sources (ECRISs)—the gasdynamic ECRIS. The gasdynamic ECRIS features a confinement mechanism in a magnetic trap that is different from Geller’s ECRIS confinement, i.e., the quasi-gasdynamic one similar to that in fusion mirror traps. Experimental studies of gasdynamic ECRIS were performed at Simple Mirror Ion Source (SMIS) 37 facility. The plasma was created by 37.5 and 75 GHz gyrotron radiation with power up to 100 kW. High frequency microwaves allowed to create and sustain plasma with significant density (up to 8 × 1013 cm−3 ) …

Alterations in Tau Protein Level and Phosphorylation State in the Brain of the Autistic-Like Rats Induced by Prenatal Exposure to Valproic Acid

2021

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by deficient social interaction and communication besides repetitive, stereotyped behaviours. A characteristic feature of ASD is altered dendritic spine density and morphology associated with synaptic plasticity disturbances. Since microtubules (MTs) regulate dendritic spine morphology and play an important role in spine development and plasticity the aim of the present study was to investigate the alterations in the content of neuronal α/β-tubulin and Tau protein level as well as phosphorylation state in the valproic acid (VPA)-induced rat model of autism. Our results indicated that maternal exposure to VPA indu…

Proteomic Analysis of Brain Region and Sex-Specific Synaptic Protein Expression in the Adult Mouse Brain

2020

Genetic disruption of synaptic proteins results in a whole variety of human neuropsychiatric disorders including intellectual disability, schizophrenia or autism spectrum disorder (ASD). In a wide range of these so-called synaptopathies a sex bias in prevalence and clinical course has been reported. Using an unbiased proteomic approach, we analyzed the proteome at the interaction site of the pre- and postsynaptic compartment, in the prefrontal cortex, hippocampus, striatum and cerebellum of male and female adult C57BL/6J mice. We were able to reveal a specific repertoire of synaptic proteins in different brain areas as it has been implied before. Additionally, we found a region-specific set…

Sympathetic, metabolic adaptations, and oxidative stress in autism spectrum disorders: How far from physiology?

2018

Autism spectrum disorders (ASD) is a complex and multifaceted neurobehavioral syndrome with no specific cause still identified, despite the worldwide increasing (prevalence for 1,000 children from 6.7 to 14.6, between 2000 and 2012). Many biological and instrumental markers have been suggested as potential predictive factors for the precocious diagnosis during infancy and/or pediatric age. Many studies reported structural and functional abnormalities in the autonomic system in subjects with ASD. Sleep problems in ASD are a prominent feature, having an impact on the social interaction of the patient. Considering the role of orexins (A and B) in wake-sleep circadian rhythm, we could speculate…

Using Zebrafish to Model Autism Spectrum Disorder: A Comparison of ASD Risk Genes Between Zebrafish and Their Mammalian Counterparts.

2020

Autism spectrum disorders (ASDs) are a highly variable and complex set of neurological disorders that alter neurodevelopment and cognitive function, which usually presents with social and learning impairments accompanied with other comorbid symptoms like hypersensitivity or hyposensitivity, or repetitive behaviors. Autism can be caused by genetic and/or environmental factors and unraveling the etiology of ASD has proven challenging, especially given that different genetic mutations can cause both similar and different phenotypes that all fall within the autism spectrum. Furthermore, the list of ASD risk genes is ever increasing making it difficult to synthesize a common theme. The use of ro…

40(th) EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004

2004

A Review of the State-of-the-Art of Assistive Technology for People with ASD in the Workplace and in Everyday Life

2019

Part 8: Digital Divide and Social Inclusion; International audience; Autism, also known as autism spectrum disorder (ASD), is an incurable brain-based disorder that refers to a wide range of complex neurodevelopment disorders characterised by marked difficulties in communication and social skills, repetitive behaviour, highly focused interests and sensory sensitivity. Autism can present challenges for affected people at the work environment and in everyday life. The barrier for individuals with ASD increases further with changing environmental situations. Individuals with ASD have limited abilities to isolate their Five senses and often experience over- or under-sensitivity to sounds, touch…

Latviešu epigrammu jeb improvizāciju otrais krājums

1808

Plašāka latviešu folkloras dokumentēšana un publicēšana uzsākta 19. gs.; pirmo krājumu autors ir Baltijas vācu izcelsmes garīdznieks – Gustavs fon Bergmans (Gustav von Bergmann ; Vidzemē ; 1749-1814). Savā tipogrāfijā iespieda pirmos latviešu tautasdziesmu jeb "latviešu gudrību, latviešu epigrammu" (lettischer Sinn- oder Stegreifs Gedichte) krājumus. Krājums satur 252 dziesmas. Izmantotas paša sastādītāja G. Bergmana, kā arī Eitnera, K. Hardera, Keslera un J. K. Šrēdera Kurzemē un Vidzemē (Cēsīs, Dikļos, Ērgļos, Limbažos, Rencēnos, Rubenē, Rūjienā un Valmierā) pierakstītās 249 latviešu tautasdziesmas un 3 mīklas. Pievienotie paskaidrojumi vācu valodā. Priekšvārdos viena tautasdziesma igauņu…

Erste Sammlung Lettischer Sinngedichte

1807

Plašāka latviešu folkloras dokumentēšana un publicēšana uzsākta 19. gs.; pirmo krājumu autors ir Baltijas vācu izcelsmes garīdznieks – Gustavs fon Bergmans (Gustav von Bergmann ; Vidzemē ; 1749-1814). Savā tipogrāfijā iespieda pirmos latviešu tautasdziesmu jeb "latviešu gudrību, latviešu epigrammu" (lettischer Sinngedichte) krājumus. Krājums satur 238 dziesmas, tautas gudrības. Pievienotie paskaidrojumi vācu valodā. Bibliogrāfiski aprakstīts: Seniespiedumi latviešu valodā, 1525-1855 / Nr. 807. Šis izdevums sastopams arī ar nos.: Sammlung ächt lettischer Sinngedichte. 1807 (Seniespiedumi latviešu valodā, 1525-1855 / Nr. 808).

Palcmariešu dziesmu krājums

1808

Frīdrihs Daniels Vārs (Friedrich Daniel Wahr ; 1749-1827) - vācu izcelsmes luterāņu mācītājs Palsmanes un Aumeisteru draudzēs. Tulkojis gan baznīcas procesijām nepieciešamo literatūru, gan zemnieku izglītošanai nepieciešamos materiālus. Savācis vienu no pirmajiem tautasdziesmu krājumiem "Palcmariešu dziesmu krājums" (1808). Palcmariešu dziesmu krājumā ievietotas 412 tautas dziesmas, sakārtotas tematiski - lauku dziesmas, dravnieku dziesmas, talku dziesmas, vedēju dziesmas, kāzu dziesmas, panāksnieku dziesmas, raudu dziesmas. Datums teksta beigās: "1807. 13. Sept:", taču gatavs bija 1808. g. vasarā. Paskaidrojumi tekstā vācu valodā. Bibliogrāfiski aprakstīts: Seniespiedumi latviešu valodā, 1…