Search results for "asic"

Understanding physical activity in adolecents with cerebral palsy from a self-determination theoretical perspective : a mixed method case study

2018

Ruiz Egea, Alfredo, 2018. Understanding physical activity in adolescents with cerebral palsy from a self-determination theoretical perspective: a mixed method case study. Master´s Thesis in Sport and Exercise Psychology. Faculty of Sport and Health Sciences. University of Jyväskylä. 75 p. The amount of research in cerebral palsy has augmented considerably during last twenty years. Increasing functional capacity in population with cerebral palsy, through physical activity has been the main goal of the research in this field during the past decades. Research sustains its effort in a basic assumption, that an increase in functionality will be followed by an increase in physical activity behavi…

Perceived autonomy support, basic needs satisfaction, motivation regulation and well-being : verification of self-determination theory in dancers in …

2010

Geme, L. 2010. Perceived autonomy support, basic need satisfaction, motivation regulation and well-being: Verification of self-determination theory in dancers in Finland. 2010 University of Jyväskylä. Master Thesis of Sport and Exercise Psychology. Department of Sport Sciences. 84 pages. Based on self-determination theory (Deci & Ryan, 2000), the main aim of the present study was to examine the relationships between perceptions of autonomy support, perceived basic need satisfaction, motivation regulation, and several indicators of physical and psychological well-being among Finnish dancers. Participants to the study were 101 Finnish professional ballet dancers (m = 35) and dance students (m…

Autonomy support, basic needs satisfaction, motivation regulation, and well-being among elite level ballet dancers in Russian speaking countries

2010

Testing the need for novelty as a candidate need in basic psychological needs theory

2020

The purpose of this research was to test novelty as a candidate basic psychological need according to the inclusion criteria established within basic psychological needs theory (BPNT). Two cross-sectional studies with 303 (Mage = 33.50, SD = 12.95; 58.41% female) and 598 (Mage = 35.47, SD = 11.89; 54.18% female) Spanish adults were conducted in physical exercise and general life contexts with the following aims: (1) to analyze relations between novelty satisfaction/frustration and well-being outcomes; (2) to examine the mediating role of motivation (autonomous, controlled, and amotivation) in these relations; and (3) to study whether these associations held regardless of the importance part…

The role of in situ species diversification for the evolution of high vascular plant species diversity in the European Alps—A review and interpretati…

2017

Abstract By harbouring ca. 3500 native vascular plant species in an area of ca. 170 000 km2, the European Alps represent a region of very high species diversity. Using the most recently published flora of the area and phylogenetic literature, I here review which proportion of the endemic flora of the Alps is the result of in situ diversification, i.e., of diversification in the area and (largely) restricted to the area. There exist only very few and mostly species-poor species diversifications in the Alps, accounting for ca. 1.2% of the native and for ca. 9% of the endemic flora of the Alps. In contrast to this, ca. 33% of the endemic species of the Alps belong to lineages widespread in the…

The assessment of skeletal status in young patients with Turner syndrome by 2 densitometric techniques: Phalangeal quantitative ultrasound and dual e…

2018

Background. Studies using dual energy X-ray absorptiometry (DXA) demonstrate a reduction in bone mineral density (BMD) in children and adolescents with Turner syndrome (TS). However, these studies do not take into account changes in bone size, which influence BMD in the case of short-statured patients. Phalangeal quantitative ultrasound (phQUS) measurements have shown an ability to reveal changes due to skeletal growth, aging, and bone and mineral disorders. There is limited data on bone mineral status in girls with TS assessed by 2 different techniques, i.e., DXA and phQUS. Objectives. The aim of this study was to investigate the potential negative impact of TS on bone status and to assess…

ShRNA-mediated knock-down of CXCL8 inhibits tumor growth in colorectal liver metastasis.

2018

CXCL8 belongs to proinflammatory chemokines that are predominantly involved in neutrophil chemotaxis and degranulation. Several studies have suggested that secretion of CXCL8 from cancer cells have a profound effect on tumor microenvironment. In this study, in continuation to our previous work of understanding the global picture of invasion related genes in colorectal liver metastases, we clearly show an up-regulation of CXCL8 expression in the tumor cells at the invasion front as compared to the tumor cells in the inner parts of the tumor. Furthermore, ShRNA mediated down-regulation of CXCL8 resulted in inhibition of cell proliferation, viability and invasion in vitro and a near complete g…

Targeting CD34+ cells of the inflamed synovial endothelium by guided nanoparticles for the treatment of rheumatoid arthritis

2019

Abstract Despite the advances in the treatment of rheumatoid arthritis (RA) achieved in the last few years, several patients are diagnosed late, do not respond to or have to stop therapy because of inefficacy and/or toxicity, leaving still a huge unmet need. Tissue-specific strategies have the potential to address some of these issues. The aim of the study is the development of a safe nanotechnology approach for tissue-specific delivery of drugs and diagnostic probes. CD34 + endothelial precursors were addressed in inflamed synovium using targeted biodegradable nanoparticles (tBNPs). These nanostructures were made of poly-lactic acid, poly-caprolactone, and PEG and then coated with a synovi…

Posttraumatic Propofol Neurotoxicity Is Mediated via the Pro–Brain-Derived Neurotrophic Factor-p75 Neurotrophin Receptor Pathway in Adult Mice*

2016

Objectives:The gamma-aminobutyric acid modulator propofol induces neuronal cell death in healthy immature brains by unbalancing neurotrophin homeostasis via p75 neurotrophin receptor signaling. In adulthood, p75 neurotrophin receptor becomes down-regulated and propofol loses its neurotoxic effect. H

Cytokine Interferon-γ suppresses the function of capsule myofibroblasts and induces cell apoptosis

2017

Myofibroblasts (MFs), a contractile subset of fibroblasts, play a pivotal role in physiological wound healing and in the development of many fibroconnective disorders. The complex cytokine network regulating the function of MFs in joint stiffness is still poorly understood. In this in vitro study, we investigated the effect of the cytokine Interferon-gamma (IFN-γ) on MFs isolated from human joint capsules. MFs were cultivated either in the presence of increasing concentrations of IFN-γ alone or in combination with IFN-γ neutralizing antibodies. Cell viability, cytotoxicity, apoptosis, and mRNA gene expression of the MF markers alpha-smooth muscle actin (α-SMA) and collagen type I were analy…