Search results for "asic"
showing 10 items of 11113 documents
Rac1-Regulated Endothelial Radiation Response Stimulates Extravasation and Metastasis That Can Be Blocked by HMG-CoA Reductase Inhibitors
2011
Radiotherapy (RT) plays a key role in cancer treatment. Although the benefit of ionizing radiation (IR) is well established, some findings raise the possibility that irradiation of the primary tumor not only triggers a killing response but also increases the metastatic potential of surviving tumor cells. Here we addressed the question of whether irradiation of normal cells outside of the primary tumor augments metastasis by stimulating the extravasation of circulating tumor cells. We show that IR exposure of human endothelial cells (EC), tumor cells (TC) or both increases TC-EC adhesion in vitro. IR-stimulated TC-EC adhesion was blocked by the HMG-CoA reductase inhibitor lovastatin. Glycyrr…
Weighted Hardy Spaces of Quasiconformal Mappings
2019
We establish a weighted version of the $H^p$-theory of quasiconformal mappings.
Microscale X-ray mapping of CZT arrays: Spatial dependence of amplitude, shape and multiplicity of detector pulses
2018
In this work, we present the results of a microscale X-ray mapping of a 2 mm thick CZT pixel detector, with pixel pitches of 500 μm and 250 μm, using collimated synchrotron X-ray sources at the Diamond Light source (U. K.). The detector is dc coupled to a fast and low noise ASIC (PIXIE ASIC), characterized only by the preamplifier stage. A custom 16-channel digital readout electronics was used, able to perform online fast pulse shape and height analysis (PSHA), with low dead time and reasonable energy resolution at both low and high fluxes. The detector allows high bias voltage operation (> 5000 V/cm) and good energy resolution at room temperature (5.3 %, 2.3 % and 2.1 % FWHM at 22.1, 59…
Enterobacter cloacae administration induces hepatic damage and subcutaneous fat accumulation in high-fat diet fed mice.
2018
Accumulating evidence indicates that gut microbiota plays a significant role in obesity, insulin resistance and associated liver disorders. Family Enterobacteriaceae and especially Enterobacter cloacae strain B29 have been previously linked to obesity and hepatic damage. The underlying mechanisms, however, remain unclear. Therefore, we comprehensively examined the effects of E. cloacae subsp. cloacae (ATCC® 13047™) administration on host metabolism of mice fed with high-fat diet (HFD). C57BL/6N mice were randomly divided into HFD control, chow control, and E. cloacae treatment groups. The E. cloacae treatment group received live bacterial cells in PBS intragastrically twice a week, every ot…
The basic psychological needs in physical education scale in Filipino
2013
The Basic Psychological Needs in Physical Education Scale (BPNPE Scale: Vlachopoulos, Katarzi, & Kontou, 2011) is a short instrument grounded in Self-Determination Theory (Ryan & Deci, 2000; 2002), designed to measure fulfillment of students’ basic needs for competence, autonomy, and relatedness in physical education context. The Greek version of this instrument has been reported to have adequate factor structure and strong internal reliability. Instruments developed in other culture need to be examined using a sample from the target culture in order to establish its cultural utility. The primary aim of this study was to explore the factor structure, construct validity, and reliability of t…
La représentation sociale de l'hygiène chez les professionnels de santé : Intérêt du recueil par entretien et de l'analyse discursive des opérateurs …
2009
This study deals with professional representations. The goal is to show the representation of hygiene by health care workers: Nurses (N) and Health Care Aides (HCA). Method follows the BSC (Bases Cognitive Schemes) procedure, explicative interviews substitute to the evaluation task. An analysis of associative words points out that for HCA hygiene is associated with acts linked with corporal hygiene and with two synonymous: no trace, no germ Discussion underlines the interest of this method for professional representations studies and nosocomial infections strength.
Talentutvikling i fotball : kan et opplevd motivasjonsklima predikere behovstilfredsstillelse og selvregulert læring hos unge talentfulle fotballspil…
2016
Masteroppgave i idrettsvitenskap - Universitetet i Agder 2016 Studies that have looked at the relationship between training and performance have sown that athletes must practice at lot in order to reach a high level (Côté et al., 2007; Ericsson et al., 1993; Simon & Chase, 1973), and motivation is viewed as an important factor in order to implement the required training. Through satisfaction of the basic needs of autonomy, competence and relatedness, athletes will feel self-determination and intrinsic motivation (Deci & Ryan, 1985). Furthermore, football players who spend more time promoting their own learning is often preferred over players taking less responsibility (Toering et al., 2012)…
Inflammatory cytokines shape a changing DNA methylome in monocytes mirroring disease activity in rheumatoid arthritis
2019
Objective: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that mainly targets joints. Monocytes and macrophages are critical in RA pathogenesis and contribute to inflammatory lesions. These extremely plastic cells respond to extracellular signals which cause epigenomic changes that define their pathogenic phenotype. Here, we interrogated how DNA methylation alterations in RA monocytes are determined by extracellular signals. Methods: High-throughput DNA methylation analyses of patients with RA and controls and in vitro cytokine stimulation were used to investigate the underlying mechanisms behind DNA methylation alterations in RA as well as their relationship with clinic…
The Clinical Value of Autoantibodies in Rheumatoid Arthritis
2018
Rheumatoid arthritis (RA) is a highly heterogeneous syndrome in terms of clinical presentation, progression, and response to therapy. In such a complicated context, the identification of disease-related biomarkers would be undoubtedly helpful in assisting tailored approaches for every patient. Despite remarkable efforts, however, progress in new biomarker development and validation is dramatically slow. At present, none of the candidate genetic, cellular, or molecular biomarker has yet surpassed the clinical value of RA-specific autoantibodies, including rheumatoid factor (RF) and anti-citrullinated protein autoantibodies (ACPA). Rather, recent years have witnessed significant advancements …
Efficacy and safety of photodynamic therapy with RLP068 for diabetic foot ulcers: a review of the literature and clinical experience
2020
This article is the second part of a literature review concerning diabetic foot ulcers (DFUs) and the use of antimicrobial photodynamic therapy (PDT). PDT involves the topical application of a photosensitiser into the tissue, followed by illumination that induces the formation of reactive oxygen species (ROS). PDT provides bacterial inactivation and promotes wound healing, and it can be used to manage the infection and microbial colonisation of DFUs. It has pivotal advantages in comparison with chemotherapeutics, such as no potential to induce resistance, and a wide spectrum of activity. Tetracationic Zn(II) phthalocyanine derivatives have been developed for PDT. Among these, we would like …