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showing 10 items of 31559 documents
Effects of endurance training on small airways of mice
2006
No effects of low-intensity endurance exercise on muscle necrosis in the diaphragm of mdx mice
2014
Duchenne muscular dystrophy (DMD) is characterized by progressive skeletal muscle weakness. We have previously shown that low-intensity endurance training prevented muscle damage (Frinchi et al, Int J Sports Med 2014). Since the effects of low-intensity endurance training on the the diaphragm in the mdx mouse model are unknown, in the same animals we investigated Cx39 protein levels (Western blotting) in homogenates of the diaphragm before and after training. Mdx and wild-type (WT) mice were randomly assigned to sedentary (mdx-S, n=17; WT-S, n=19) or trained (mdx-EX, n=14; WT-EX, n=16) groups. Low-intensity endurance training (running on a wheel) was done 5 days/week for 6 weeks at progress…
Extracellular Vesicle microRNAs Contribute to the Osteogenic Inhibition of Mesenchymal Stem Cells in Multiple Myeloma
2020
Osteolytic bone disease is the major complication associated with the progression of multiple myeloma (MM). Recently, extracellular vesicles (EVs) have emerged as mediators of MM-associated bone disease by inhibiting the osteogenic differentiation of human mesenchymal stem cells (hMSCs). Here, we investigated a correlation between the EV-mediated osteogenic inhibition and MM vesicle content, focusing on miRNAs. By the use of a MicroRNA Card, we identified a pool of miRNAs, highly expressed in EVs, from MM cell line (MM1.S EVs), expression of which was confirmed in EVs from bone marrow (BM) plasma of patients affected by smoldering myeloma (SMM) and MM. Notably,we found that miR-129-5p, whic…
Longitudinal Gait Analysis of a Transfemoral Amputee Patient: Single-Case Report from Socket-Type to Osseointegrated Prosthesis
2023
The aim of the present case report was to provide a longitudinal functional assessment of a patient with transfemoral amputation from the preoperative status with socket-type prosthesis to one year after the osseointegration surgery. A 44 years-old male patient was scheduled for osseointegration surgery 17 years after transfemoral amputation. Gait analysis was performed through 15 wearable inertial sensors (MTw Awinda, Xsens) before surgery (patient wearing his standard socket-type prosthesis) and at 3-, 6-, and 12-month follow-ups after osseointegration. ANOVA in Statistical Parametric Mapping was used to assess the changes in amputee and sound limb hip and pelvis kinematics. The gait symm…
The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress.
2021
Summary: Chromatin organization plays a crucial role in tissue homeostasis. Heterochromatin relaxation and consequent unscheduled mobilization of transposable elements (TEs) are emerging as key contributors of aging and aging-related pathologies, including Alzheimer’s disease (AD) and cancer. However, the mechanisms governing heterochromatin maintenance or its relaxation in pathological conditions remain poorly understood. Here we show that PIN1, the only phosphorylation-specific cis/trans prolyl isomerase, whose loss is associated with premature aging and AD, is essential to preserve heterochromatin. We demonstrate that this PIN1 function is conserved from Drosophila to humans and prevents…
Search for photonic signatures of gauge-mediated supersymmetry in 8TeV pp collisions with the ATLAS detector
2015
A search is presented for photonic signatures motivated by generalized models of gauge-mediated supersymmetry breaking. This search makes use of 20.3 fb[superscript −1] of proton-proton collision data at √s = 8 TeV recorded by the ATLAS detector at the LHC, and explores models dominated by both strong and electroweak production of supersymmetric partner states. Four experimental signatures incorporating an isolated photon and significant missing transverse momentum are explored. These signatures include events with an additional photon, lepton, b-quark jet, or jet activity not associated with any specific underlying quark flavor. No significant excess of events is observed above the Stand…
Recommendations of the LHC Dark Matter Working Group: Comparing LHC searches for dark matter mediators in visible and invisible decay channels and ca…
2019
Physics of the Dark Universe 26, 100377 (2019). doi:10.1016/j.dark.2019.100377
Images - Computed tomography urographic appearance of traumatic rupture of renal cyst into the pyelocaliceal system.
2019
Spontaneous or traumatic rupture of renal cysts, documented by radiological imaging, occurs infrequently. The pathogenesis of a cyst rupture is still unclear, except when it has occurred following trauma or when the cyst has become infected. Imaging plays a crucial role in the diagnosis, management, surveillance, and choice of lesions that need treatment.
Anatomy of the "false thumb" of Tremarctos ornatus (Carnivora, Ursidae, Tremarctinae): Phylogenetic and functional implications
2006
6 pages, 3 figures.
Diversidad genética de los principales vectores de la enfermedad de Chagas en Brasil: repercusiones epidemiológicas en el control de la enfermedad
2017
La enfermedad de Chagas, también llamada Tripanosomiasis Americana, es una enfermedad potencialmente mortal causada por el parásito protozoo Trypanosoma cruzi, es endémica de América Latina y transmitida, principalmente, por vectores hemípteros de la subfamilia Triatominae adaptados a los hábitats doméstico y peridoméstico. Puesto que el parásito se mantiene en un ciclo zoonótico silvestre y es imposible de eliminar, la única forma de luchar contra la transmisión vectorial consiste en la eliminación de las poblaciones domiciliadas del vector. Los estudios moleculares constituyen una herramienta de gran utilidad a la hora de planificar las campañas de control vectorial, puesto que permiten c…