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showing 10 items of 7176 documents
Barbara Godard, a Translator's Portrait: Analysing the Reception of Québec's Roman au Féminin (1960-1990) in Anglophone Canada
2021
The current dissertation is not only concerned with nourishing the Feminist Translation Studies field with an interdisciplinary perspective into Feminist Translator History. It strives for an understanding of Translation Studies, and Feminist Translation Studies in this particular case, as a cross-disciplinary space where the aims of various disciplines may converge (see Castro 2012). In the particular space of Feminist Translation/Translator History, and in line with Rundle's proposed synergies between Translation Studies and History (2014), the limitations of the so-called "discursive turn" in Feminist History" (Canning 1994) which, despite showing interest in how ideologies operate via h…
Noves prestacions al Serveis Socials: per a qui? per a què? La Llei Valenciana de Protecció a la Maternitat
2010
The Generalitat Valenciana (Valencia Autonomous Community Authority) approved the maternity protection law one year ago. In this article, we talk about this law, its development and its connection with Valencian social services. We also make a point about the situation of social services faced with longstanding and new social needs to guarantee protection for people and groups in a vulnerability and/ or social exclusion situation. We conclude with the affirmation that this law does not propose any new policy in favour of maternity or anything new for the weak structure of social services.
Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo
2021
Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…
Elucidation of antioxidant properties of wood bark derived saturated diarylheptanoids: a comprehensive (DFT-supported) understanding.
2013
A series of diarylheptanoids, namely 1,7-bis-(3,4-dihydroxyphenyl)-heptan-3-one-5-O-D-xylopyranoside (oregonin), 1,7-bis-(3,4-dihydroxyphenyl)-3-hydroxyheptane-5-O-β-D-xylopyranoside and 1,7-bis-(4-hydroxyphenyl)-heptane-3-one-5-O-β-D-glucopyranoside (platyphylloside), were isolated from the bark of alder family trees, a species widely spread over in Europe. As antioxidants, these natural polyphenols have a promising potential in various fields of application, but their redox reactivity is insufficiently characterized. In this work, their antioxidant activity is described using assays based on DPPH and ABTS(+) radical scavenging, oxygen anion radicals (O2(-)) quenching. The standardized ORA…
Time-Varying mHAP-III Is the Most Accurate Predictor of Survival in Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization
2021
<b><i>Introduction:</i></b> The prognosis of patients undergoing transarterial chemoembolization (TACE) is extremely variable, and a confounding factor is that TACE is often repeated several times. We retrospectively evaluated the accuracy of different prognostic scores and staging systems in estimating overall survival (OS) in patients with hepatocellular carcinoma (HCC). <b><i>Methods:</i></b> An analysis considering prognostic models as time-varying variables was performed, calculating OS from the time of TACE to the time of the subsequent treatment. Total follow-up time for each patient was therefore split into several observation times ac…
Heavy flavour decay muon production at forward rapidity in proton--proton collisions at sqrt(s) = 7 TeV
2012
The production of muons from heavy flavour decays is measured at forward rapidity in proton-proton collisions at $\sqrt{s} = 7$ TeV collected with the ALICE experiment at the LHC. The analysis is carried out on a data sample corresponding to an integrated luminosity $L_{\rm int} = 16.5$ nb$^{-1}$. The transverse momentum and rapidity differential production cross sections of muons from heavy flavour decays are measured in the rapidity range 2.5 < y < 4, over the transverse momentum range 2 < $p_{\rm T}$ < 12 GeV/$c$. The results are compared to predictions based on perturbative QCD calculations.
Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: Insights from the LUNG SAFE study
2020
Abstract Background Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence o…
Rutas y cargamento de vino itálico en Época Republicana en la Hispania Citerior
2017
El período de la Roma republicana fue el momento de mayor comercialización del vino itálico, sobre todo en las costas de Hispania Citerior. La arqueología tanto terrestre como subacuática nos muestra las evidencias de este comercio en las costas del Mediterráneo peninsular y nos ayuda a hacernos una gran idea de las diferentes rutas comerciales marítimas y cuáles eran los cargamentos de los cientos de barcos que comerciaban. En el siguiente artículo nos centraremos en las diferentes rutas de vino que provenían de la península itálica, los cargamentos de vino, al igual que sus contenedores, cronologías en relación a los envases, zona de producción anfórica y de vino, y por último, un breve v…
Alkamides from Echinacea angustifolia Interact with P-Glycoprotein of Primary Brain Capillary Endothelial Cells Isolated from Porcine Brain Blood Ves…
2013
The blood-brain barrier prevents the passage of toxic compounds from blood circulation into brain tissue. Unfortunately, drugs for the treatment of neurodegenerative diseases, brain tumors, and other diseases also do not cross the blood-brain barrier. In the present investigation, we used isolated porcine brain capillary endothelial cells and a flow cytometric calcein-AM assay to analyze inhibition of P-glycoprotein, a major constituent of the blood-brain barrier. We tested 8 alkamides isolated from Echinacea angustifolia and found that four of them inhibited P-glycoprotein-mediated calcein transport in porcine brain capillary endothelial cells.
Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics
2021
Graphical abstract