6533b85cfe1ef96bd12bd4b5

RESEARCH PRODUCT

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: Insights from the LUNG SAFE study

Madotto FRezoagli EPham TSchmidt MMcnicholas BProtti APanwar RBellani GFan EVan Haren FBrochard LLaffey JgAntonio PesentiJohn G LaffeyLaurent BrochardAndres EstebanLuciano GattinoniFrank Van HarenAnders LarssonDaniel F McauleyMarco RanieriGordon RubenfeldB Taylor ThompsonHermann WriggeArthur S SlutskyFernando RiosT SottiauxP DepuydtFredy S LoraLuciano Cesar AzevedoEddy FanGuillermo BugedoHaibo QiuMarcos GonzalezJuan SileskyVladimir CernyJonas NielsenManuel JibajaTài PhamDimitrios MatamisJorge Luis RaneroPravin AminS M HashemianKevin ClarksonGiacomo BellaniKiyoyasu KurahashiAsisclo VillagomezAmine Ali ZeggwaghLeo M HeunksJon Henrik LaakeJose Emmanuel PaloAntero Do Vale FernandesDorel SandescYaasen ArabiVesna BumbasierevicNicolas NinJose A LorenteLise PiquilloudFekri AbrougDaniel F McauleyLia McnameeJavier HurtadoEd BajwaGabriel DémpaireUhc Mother TheresaHektor SulaLordian NunciAlma CaniVilla MariaAlan ZazuChristian DelleraCarolina S InsaurraldeRisso V AlejandroJulio DaldinMauricio VinzioRuben O FernandezLuis P CardonnetLisandro R BettiniMariano Carboni BissoEmilio M OsmanMariano G SettenPablo LovazzanoJavier AlvarezVeronica VillarNorberto C PozoNicolas GrubissichGustavo A PlotnikowDaniela N VasquezSantiago IlutovichNorberto TiribelliAriel ChenaCarlos A PellegriniMaría G SaenzElisa EstenssoroMatias BrizuelaHernan GianinettoPablo E GomezValeria I CerratoMarco G BezziSilvina A BorelloFlavia A LoiaconoAdriana M FernandezSerena KnowlesClaire ReynoldsDeborah M InskipJennene J MillerJing KongChristina WhiteheadShailesh BihariAylin SevenAmanda KrstevskiHelen J RodgersRebecca T MillarToni E MckennaIrene M BaileyGabrielle C HanlonAnders AnemanJoan M LynchRaman AzadJohn NealPaul W WoodsBrigit L RobertsMark R KolHelen S WongKatharina C RissThomas StaudingerXavier WitteboleCaroline BerghePierre A BulpaAlain M DiveRik VerstraeteHerve LebbinckPieter DepuydtJoris VermassenPhilippe MeerssemanHelga CeunenJonas I RosaDaniel O BeraldoClaudio PirasAdenilton M RampinelliAntonio P Nassar JrSergio MatalounMarcelo MoockMarlus M ThompsonClaudio H GonçalvesAna Carolina P AntônioAline AscoliRodrigo S BiondiDanielle C FonteneleDanielle NobregaVanessa M SalesSuresh ShindheDk Maizatul Aiman B Pg Hj IsmailJohn LaffeyFrancois BeloncleKyle G DaviesRob CironeVenika ManoharanMehvish IsmailEwan C GoligherMandeep JassalErin NishikawaAreej JaveedGerard CurleyNuttapol RittayamaiMatteo ParottoNiall D FergusonSangeeta MehtaJenny KnollAntoine PronovostSergio CanestriniAlejandro R BruhnPatricio H GarciaFelipe A AliagaPamela A FaríasJacob S YumhaClaudia A OrtizJavier E SalasAlejandro A SaezLuis D VegaEduardo F LabarcaFelipe T MartinezNicolás G CarreñoPilar LoraHaitao LiuLing LiuRui TangXiaoming LuoYouzhong AnHuiying ZhaoYan GaoZhe ZhaiZheng L YeWei WangWenwen LiQingdong LiRuiqiang ZhengWenkui YuJuanhong ShenXinyu LiTao YuWeihua LuYa Q WuXiao B HuangZhenyang HeYuanhua LuHui HanFan ZhangRenhua SunHua X WangShu H QinBao H ZhuJun ZhaoJian LiuBin LiJing L LiuFa C ZhouQiong J LiXing Y ZhangZhou Li-xinQiang Xin-huaLiangyan JiangYuan N GaoXian Y ZhaoYuan Y LiXiao L LiChunting WangQingchun YaoRongguo YuKai ChenHuanzhang ShaoBingyu QinQing Q HuangWei H ZhuAi Y HangMa X HuaYimin LiYonghao XuYu D DiLong L LingTie H QinShou H WangJunping QinYi HanSuming ZhouMonica P VargasJuan I Silesky JimenezManuel A González RojasJaime E Solis-quesadaChristian M Ramirez-alfaroJan MácaPeter SklienkaJakob GjedstedAage ChristiansenBoris G VillamaguaMiguel LlanoPhilippe BurtinGautier BuzancaisPascal BeuretNicolas PelletierSatar MortazaAlain MercatJonathan ChellySébastien JochmansNicolas TerziCédric DaubinGuillaume CarteauxNicolas De ProstJean-daniel ChicheFabrice DaviaudTai PhamMuriel FartoukhGuillaume BarberetJerome BiehlerJean DellamonicaDenis DoyenJean-michel ArnalAnais BriquetSami HraiechLaurent PapazianArnaud FollinDamien RouxJonathan MessikaEvangelos KalaitzisLaurence DangersAlain CombesSiu-ming AuGaetan BéduneauDorothée CarpentierElie H ZogheibHerve DupontSylvie RicomeFrancesco L SantoliSebastien L BessetPhilippe MichelBruno GeléePierre-eric DaninBernard GoubauxPhilippe J CrovaNga T PhanFrantz BerkelmansJulio C BadieRomain TapponnierJosette GallySamy KhebbebJean-etienne HerbrechtFrancis SchneiderPierre-louis M DeclercqJean-philippe RigaudJacques DuranteauAnatole HarroisRussell ChabanneJulien MarinCharlene BigotSandrine ThibaultMohammed GhaziMessabi BoukhaznaSalem Ould ZeinJack R RichecoeurDaniele M CombauxFabien GrelonCharlene Le MoalElise P SauvadetAdrien RobineVirginie LemialeDanielle ReuterMartin DresAlexandre DemouleDany Goldgran-toledanoLoredana BaboiClaude GuérinRalph LohnerJens KraßlerSusanne SchäferKai D ZacharowskiPatrick MeybohmAndreas W ReskePhilipp SimonHans-bernd F HopfMichael SchuetzThomas BaltusMetaxia N PapanikolaouTheonymfi G PapavasilopoulouGiannis A ZacharasVasilis OurailogloyEleni K MouloudiEleni V MassaEva O NagyElectra E StamouEllada V KiourtzievaMarina A OikonomouLuis E AvilaCesar A CortezJohanna E CitalánSameer A JogSafal D SableBhagyesh ShahMohan GurjarArvind K BaroniaMohammedfaruk MemonRadhakrishnan MuthuchellappanVenkatapura J RameshAnitha ShenoyRamesh UnnikrishnanSubhal B DixitRachana V RhayakarNagarajan RamakrishnanVallish K BhardwajHeera L MahtoSudha V SagarVijayanand PalaniswamyDeeban GanesanSeyed Mohammadreza HashemianHamidreza JamaatiFarshad HeidariEdel A MeaneyAlistair NicholKarl M KnapmanDonall O'croininEimhin S DunneDorothy M BreenKevin P ClarksonRola F JaafarRory DwyerFahd AmirOlaitan O AjetunmobiAogan C O'muircheartaighColin S BlackNuala TreanorDaniel V CollinsWahid AltafGianluca ZaniMaurizio FusariSavino SpadaroCarlo A VoltaRomano GrazianiBarbara BrunettiniSalvatore PalmesePaolo FormentiMichele UmbrelloAndrea LombardoElisabetta PecciMarco BotteriMonica SavioliAlessandro ProttiAlessia MatteiLorenzo SchiavoniAndrea TinnirelloManuel TodeschiniAntonino GiarratanoAndrea CortegianiSara SherAnna RossiMassimo M AntonelliLuca M MontiniPaolo CasalenaSergio ScafettiGiovanna PanarelloGiovanna OcchipintiNicolò PatronitiMatteo PozziRoberto R BiscioneMichela M PoliFerdinando RaimondiDaniela AlbieroGiulia CrapelliEduardo BeckVincenzo PotaVincenzo SchiavoneAlexandre MolinFabio TarantinoGiacomo MontiElena FratiLucia MirabellaGilda CinnellaTommaso FossaliRiccardo ColomboPierpaolo Terragni Ilaria PattarinoFrancesco MojoliAntonio BraschiErika E BorottoAndrea N CracchioloDaniela M PalmaFrancesco RaponiGiuseppe FotiEttore R VascottoAndrea CoppadoroLuca BrazziLeda FlorisGiorgio A IottiAaron VentiOsamu YamaguchiShunsuke TakagiHiroki N MaeyamaEizo WatanabeYoshihiro YamajiKazuyoshi ShimizuKyoko ShiozakiSatoru FutamiSekine RyosukeKoji SaitoYoshinobu KameyamaKeiko UenoMasayo IzawaNao OkudaHiroyuki SuzukiTomofumi HarasawaMichitaka NasuTadaaki TakadaFumihito ItoShin-nunomiya Kansuke-koyamaToshikazu AbeKohkichi AndohKohei KusumotoAkira HirataAkihiro TakabaHiroyasu KimuraShuhei MatsumotoUshio HigashijimaHiroyuki HondaNobumasa AokiHiroshi ImaiYasuaki OginoIchiko MizuguchiKazuya IchikadoKenichi NittaKatsunori MochizukiTomoaki HashidaHiroyuki TanakaTomoyuki NakamuraDaisuke NiimiTakeshi UedaYozo KashiwaAkinori UchiyamaOlegs SabelnikovsPeteris OssYoussef HaddadKong Y LiewSilvio A ÑAmendys-silvaYves D Jarquin-badiolaLuis A Sanchez-hurtadoSaira S Gomez-floresMaria C MarinAsisclo J VillagomezJordana S LemusJonathan M FierroMavy Ramirez CervantesFrancisco Javier Flores MejiaDulce DectorDulce M DectorDaniel R GonzalezClaudia R EstrellaJorge R Sanchez-medinaAlvaro Ramirez-gutierrezFernando G GeorgeJanet S AguirreJuan A BuensusesoManuel PoblanoTarek DendaneHicham BalkhiMina ElkhayariNacer SamkaouiHanane EzzouineAbdellatif Benslama Mourad AmorWajdi MaazouziNedim CimicOliver BeckMonique M BrunsJeroen A SchoutenMyra-riniaMonique RaaijmakersHellen M Van WezelSerge J HeinesUlrich StrauchMarc P BuiseFabienne D SimonisMarcus J SchultzJennifer C GoodsonTroy S BrowneLeanlove NavarraAnna HuntRobyn A HutchisonMathew B BaileyLynette NewbyColin McarthurMichael KalkoffAlex McleodJonathan CasementDanielle J HackingFinn H AndersenMerete S DolvaJon H LaakeAndreas Barratt-dueKim Andre L NoremarkEldar SøreideBrit Å SjøbøAnne B GuttormsenHector H Leon YoshidoRonald Zumaran AguilarFredy A Montes OscanoaAlain U AlisasisJoanne B RoblesRossini Abbie B Pasanting-limBeatriz C TanPawel AndruszkiewiczKarina JakubowskaCristina M CoxoAntónio M AlvarezBruno S OliveiraGustavo M MontanhaNelson C BarrosCarlos S PereiraAntónio M MessiasJorge M MonteiroAna M AraujoNuno T CatorzeSusan M MarumMaria J BouwRui M GomesVania A BritoSilvia CastroJoana M EstilitaFilipa M BarrosIsabel M SerraAurelia M MartinhoDana R TomescuAlexandra MarcuOvidiu H BedreagMarius PapuricaDan E CorneciSilvius Ioan NegoitaEvgeny GrigorievAlexey I GritsanAndrey A GazenkampfGhaleb AlmekhlafiMohamad M AlbarrakGhanem M MustafaKhalid A MaghrabiNawal SalahuddinTharwat M AisaAhmed S Al JabbaryEdgardo TabhanYaseen M ArabiOlivia A TrinidadHasan M Al DorziEdgardo E TabhanStefan BolonOliver SmithJordi ManceboHernan Aguirre-bermeoJuan C Lopez-delgadoFrancisco EsteveGemma RialpCatalina FortezaCandelaria De HaroAntonio ArtigasGuillermo M AlbaicetaSara De Cima-iglesiasLeticia Seoane-quirogaAlexandra Ceniceros-barrosAntonio L Ruiz-aguilarLuis M Claraco-vegaJuan Alfonso SolerMaria Del Carmen LorenteCecilia HermosaFederico GordoMiryam-prieto-gonzálezJuan B López-messaManuel P PerezCesar P PerezRaquel Montoiro AllueFerran Roche-campoMarcos Ibañez-santacruzSusana-tempranoMaria C PintadoRaul De PabloPilar Ricart Aroa GómezSilvia Rodriguez RuizSilvia Iglesias MolesMª Teresa JuradoAlfons ArizmendiEnrique A PiacentiniNieves FrancoTeresa HonrubiaMeisy Perez ChengElena Perez LosadaJavier-blancoLuis J YusteCecilia Carbayo-gorrizFrancisca G Cazorla-barranqueroJavier G AlonsoRosa S AldaÁNgela AlgabaGonzalo NavarroEnrique CereijoEsther Diaz-rodriguezDiego Pastor MarcosLaura Alvarez MonteroLuis Herrera ParaRoberto Jimenez SanchezMiguel Angel Blasco NavalpotroRicardo Diaz AbadRaquel Montiel Gonz Á LezD Á Cil Parrilla ToribioAlejandro G CastroMaria Jose D ArtigaOscar PenuelasTomas P RoserMoreno F OlgaElena Gallego CurtoRocío Manzano SánchezVallverdu P ImmaGarcia M ElisabetLaura ClaveriasMonica MagretAna M PellicerLucia L RodriguezJesús Sánchez-ballesterosÁNgela González-salamancaAntonio G JimenezFrancisco P HuertaJuan Carlos J Sotillo DiazEsther Bermejo LopezDavid D Llinares MoyaAlec A Tallet AlfonsoPalazon Sanchez Eugenio LuisPalazon Sanchez CesarSánchez I RafaelCorcoles G VirgilioNoelia N RecioRichard O AdamssonChristian C RylanderBernhard HolzgraefeLars M BromanJoanna WessberghLinnea PerssonFredrik SchiölerHans KedelvAnna Oscarsson TibblinHenrik AppelbergLars HedlundJohan HellebergKarin E ErikssonRita GlietschNiklas LarssonIngela NygrenSilvia L NunesAnna-karin MorinThomas KanderAnne AdolfssonHervé O ZenderCorinne Leemann-refondiniSouheil ElatrousSlaheddine BouchouchaImed ChoucheneIslem OuanesAsma Ben SouissiSalma KamounOktay DemirkiranMustafa AkerEmre ErbabacanIlkay CeylanNermin Kelebek GirginMenekse OzcelikNecmettin ÜNalBasak Ceyda MecoOnat O AkyolSuleyman S DermanBarry KennedyKen ParharLatha SrinivasaDanny McauleyPhil HopkinsClare MellisVivek KakarDan HadfieldAndre VercueilKaushik BhowmickSally K HumphreysAndrew FergusonRaymond MckeeAshok S RajDanielle A FawkesPhilip WattLinda TwoheyRajeev R Jhamatthew ThomasAlex MortonVarsha KadabaMark J SmithAnil P HormisSanthana G KannanMiriam NamihHenrik ReschreiterJulie CamsooksaiAlek KumarSzabolcs RugonfalviChristopher NuttOrla O'neillColette SeasmanGed DempseyChristopher J ScottHelen E EllisStuart MckechniePaula J HuttonNora N Di TomassoMichela N VitaleRuth O GriffinMichael N DeanJulius H CranshawEmma L WillettNicholas IoannouSarah GillisPeter CsabiRosaleen MacfadyenHeidi DawsonPieter D PreezAlexandra J WilliamsOwen BoydLaura Ortiz-ruiz De GordoaJon BramallSophie SymmondsSimon K ChauTim WenhamTamas SzakmanyPiroska Toth-tarsolyKatie H MccalmanPeter AlexanderLorraine StephensonThomas CollyerRhiannon ChapmanRaphael CooperRussell M AllanMalcolm SimDavid W WrathallDonald A IrvineKim S ZantuaJohn C AdamsAndrew J BurtenshawGareth P SellorsIngeborg D WeltersKaren E WilliamsRobert J HessellMatthew G OldroydCeri E BattleSuresh PillaiIstvan KajtorMageswaran SivashanmugavelSinead C O'kaneAdrian DonnellyAniko D FrigyikJon P CarelessMartin M MayRichard StewartT John TrinderSamantha J HaganMatt P WiseJade M ColeCaroline C MacfieAnna T DowlingNicolás NinEdgardo NuñezGustavo PittiniRuben RodriguezMaría C ImperioCristina SantosAna G FrançaAlejandro EbeidAlberto DeicasCarolina SerraAditya UppalapatiGhassan KamelValerie M Banner-goodspeedJeremy R BeitlerSatyanarayana Reddy MukkeraShreedhar KulkarniJarone LeeTomaz MesarJohn O Shinn 3rdDina GomaaChristopher TainterDale J YeattsJessica WarrenMichael J LanspaRussel R MillerColin K GrissomMadotto FRezoagli EPham TSchmidt MMcnicholas BProtti APanwar RBellani GFan EVan Haren FBrochard LLaffey JgLung Safe Investigators And The Esicm Trials GroupSamuel M BrownPhilippe R BauerRyan J GosselinBarrett T KitchJason E CohenScott H BeegleRenaud M GueretAiman TulaimatShazia ChoudryWilliam StiglerHitesh BatraNidhi G HuffKeith D LambTrevor W OettingNicholas M MohrClaine JudyShigeki SaitoFayez M KheirFayez KheirAdam B SchlichtingAngela DelsingDaniel R CrouchMary ElmasriDina IsmailKyle R DreyerThomas C BlakemanRebecca M BaronCarolina Quintana GrijalbaPeter C HouRaghu SeethalaImo AisikuGalen HendersonGyorgy FrendlSen-kuang HouRobert L OwensAshley SchomerVesna BumbasirevicBojan JovanovicMaja SurbatovicMilic Veljovic

subject

ARDSmedicine.medical_treatment030204 cardiovascular system & hematologyCritical Care and Intensive Care MedicineHyperoxemiaHypoxemialaw.inventionHypoxemia0302 clinical medicinelawFraction of inspired oxygenOxygen therapyPrevalenceMedicineHypoxiaAcute respiratory distress syndrome; Hyperoxemia; Hyperoxia; Hypoxemia; Hypoxia; Invasive mechanical ventilation; Mortality; Oxygen therapy;Respiratory Distress SyndromeHyperbaric OxygenationAcute respiratory distress syndromeRespirationlcsh:Medical emergencies. Critical care. Intensive care. First aidHyperoxemiaIntensive care unitIntensive Care UnitsAnesthesiaArtificialmedicine.symptomHumanArtificial ventilationAcute respiratory distress syndrome; Hyperoxemia; Hyperoxia; Hypoxemia; Hypoxia; Invasive mechanical ventilation; Mortality; Oxygen therapyIntensive Care UnitHyperoxiaNO03 medical and health sciencesIntensive careSettore MED/41 - ANESTESIOLOGIAHumansInvasive mechanical ventilationMortalitybusiness.industryResearchRespiratory Distress Syndrome Adultlcsh:RC86-88.9medicine.diseaseOxygen therapyRespiration Artificialrespiratory tract diseasesOxygenlnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4]030228 respiratory systembusiness

description

Abstract Background Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55–100 mmHg) patients (P = 0.47). Conclusions Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073

yearjournalcountryeditionlanguage
2020-03-01
10.1186/s13054-020-2826-6http://hdl.handle.net/11591/446803