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Optimized In Silico Modeling of Drug Absorption after Gastric Bypass: The Case of Metformin

2021

Bariatric surgery is an effective treatment for severe obesity and related comorbidities, such as type II diabetes. Gastric bypass surgery shortens the length of the intestine, possibly leading to altered drug absorption. Metformin, a first-line treatment for type II diabetes, has permeability-dependent drug absorption, which may be sensitive to intestinal anatomic changes during bypass surgery, including Roux-en-Y gastric bypass (RYGB). Previous computer simulation data indicate increased metformin absorption after RYGB. In this study, we experimentally determined the region-dependent permeability of metformin, using the rat single-pass intestinal perfusion method (SPIP), which we then imp…

Breve noticia de los principios, y progresos de la Academia de Pintura, Escultura, y Architectura, erigida en la Ciudad de Valencia, baxo el titulo d…

Corren altres impressions del mateix tex, any i impressor, amb diferències en la disposició del text, gravats, nº de pàg., sign. tip., etc Els grav. calc. El de la p. 1 "Ant. Gonzz. invt". "Palomºinct.". En la vinyeta del final "V Pz" Ornament tip. a la port., caplletres grav Sign.: [ ]2, A-E4 Reclams

Remembrance of the historian Vicent Llombart

2017

Esta evocación muestra cómo la formación inicial que recibió Vicent Llombart en el Seminario de historia del pensamiento económico en la Universidad de Valencia fue decisiva, pero no suficiente, para entender una trayectoria rotunda por sus contribuciones. Su propósito decidido, su firme exigencia personal y su apertura intelectual permanente nos ayudan a comprender mejor a un gran historiador. This remembrance shows how the initial training that Vicent Llombart received at the Seminar on the History of Economic Thought at the University of Valencia was crucial, although not the only element, to understanding a prominent academic career with so relevant contributions. His determined purpose…

Trencalòs, Quebrantahuesos (VER0000130)

1862

Altres noms vulgars: Lammergeier (Anglès), Gypaète barbu (Francès), Bartgeier (Alemany) Gabinet de Vertebrats (Departament de Zoologia), Facultat de Ciències Biològiques (Campus de Burjassot), C/ Doctor Moliner, s/n, Bloque B. 5é plant, Burjassot (Valencia). Armari: 6-1 Valencia 12/03/1862 Juvenil

Trencalòs, Quebrantahuesos (VER0000218)

Lammergeier (Anglès), Gypaète barbu (Francès), Bartgeier (Alemany) Gabinet de Vertebrats (Departament de Zoologia), Facultat de Ciències Biològiques (Campus de Burjassot), C/ Doctor Moliner, s/n, Bloque B. 5é plant, Burjassot (Valencia). Armari: 6-1 Requena (Valencia)/Cayena, 1852 Adulto Adulto/Juvenil barbatus _

Trencalòs, Quebrantahuesos (VER0000129)

Altres noms vulgars: Lammergeier (Anglès), Gypaète barbu (Francès), Bartgeier (Alemany) Gabinet de Vertebrats (Departament de Zoologia), Facultat de Ciències Biològiques (Campus de Burjassot), C/ Doctor Moliner, s/n, Bloque B. 5é plant, Burjassot (Valencia). Armari: 6-2 Sagunto Macho Adulto

Il contratto collettivo aziendale in una prospettiva comparata. Italia, Francia, Spagna e Stati Uniti a confronto

2014

Sulla scorta del metodo comparato, la tesi analizza le recenti modifiche alla disciplina del contratto collettivo aziendale in Italia, Francia e Spagna, introdotte dalla legge e dagli accordi interconfederali; l'obiettivo è dimostrare un tendenziale avvicinamento degli stati europei analizzati al sistema nord-americano di relazioni industriali, in cui il rapporto di lavoro è regolato non tanto dalla legge o dall'accordo di categoria, ma dal contratto aziendale.Vengono inoltre analizzati i recenti accordi collettivi firmati alla Fiat ed alla Chrysler a partire dal processo di integrazione iniziato nel 2009. According to the comparative method, the thesis analyses the recent changes to the di…

Isocratic high-performance liquid chromatographic determination of tryptophan in infant formulas.

1996

The application to infant formulas of a method for tryptophan determination by isocratic HPLC with UV detection at 254 nm, after derivatization with phenyl isothiocyanate, was studied. Protein was hydrolysed by barium hydroxide at 120 degrees C for 8 h, followed by derivatization with phenyl isothiocyanate, HPLC and UV detection at 254 nm. The optimum chromatographic conditions (pH, ionic strength of elution solvent and eluent ratio) were established. The analytical parameters (linearity, precision, accuracy of derivatization and limits of detection and quantification) were determined. The values obtained demonstrated that the method is useful for determining the tryptophan content of infan…

Room temperature acid sonication ICP-MS multielemental analysis of milk

2005

Abstract Room temperature acid sonication of milk samples is proposed as a fast alternative methodology for the determination of the total content of 45 elements (Li, Al, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Rb, Sr, Y, Mo, Ag, Cd, In, Sn, U, Sb, Te, Cs, Ba, Hg, Pb, Bi, Th, La, Ce, Pr, Nd, Sm, Eu, Gd, Dy, Ho, Er, Tm, Yb, Lu, Hf and Ta) in milk by inductively coupled plasma mass spectrometry (ICP-MS). The aforementioned procedure involves a 10 min sample pre-treatment. Measurements were made in quantitative and semiquantitative (Totalquant ® ) modes of analysis using Rh as internal standard and Be, Ge, Tb and Re for internal calibration of the equipment in the semiquantitative mode. The…

Molecular Recognition by Hydrogen Bonding in Polyelectrolyte Multilayers

1997

Functional polyanions were prepared by copolymerization of sulfopropyl acrylate and sulfopropyl methacrylate with monomers bearing triaminopyrimidine or barbituric acid functionalities, respectively. Functionalized polyelectrolyte multilayers were assembled from these copolymers by stepwise alternating adsorption with poly(choline methacrylate). These multilayers are suited for molecular recognition of substrates that are complementary to the functional groups incorporated. Thus, multilayers containing triaminopyrimidine moieties selectively bind barbituric acid, and vice versa, when exposed to solutions of the 1:1 complex of barbituric acid and triaminopyrimidine. The molecular recognition…