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showing 10 items of 7176 documents

Treatment of painful radiculopathies with capsaicin 8% cutaneous patch.

2017

The treatment of neuropathic pain due to low-back (lumbosacral) radiculopathies, a common source of neuropathic pain, is challenging and often requires a multimodal therapeutic approach. The capsaicin 8% patch is the first topical analgesic licensed for peripheral neuropathic pain. To evaluate this treatment, a subset of patients with painful radiculopathy (lumbar and cervical, including ventral and dorsal rami) enrolled into the multicenter, non-interventional QUEPP study (QutenzaOf the 1044 study participants, 50 were diagnosed with painful radiculopathy as only peripheral neuropathic pain syndrome and were eligible for evaluation. Patients received a single treatment (visit 1) with follo…

AdultMaleAdministration Cutaneous03 medical and health sciences0302 clinical medicineLumbarQuality of life030202 anesthesiologySurveys and QuestionnairesMedicineHumansRadiculopathyAgedReferred painbusiness.industryPruritusGeneral MedicineMiddle Agedmedicine.diseaseLow back painSpineTreatment OutcomeAnesthesiaNeuropathic painNeuralgiaQuality of LifeNeuralgiaFemalemedicine.symptomCapsaicinbusinessRadiculopathies030217 neurology & neurosurgeryLumbosacral jointCurrent medical research and opinion
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Prevalence of alexithymia in eating disorders in a clinical sample of 800 Mexican patients.

2019

The inability to identify, express feelings, and not distinguish between emotions and bodily sensations, is known as alexithymia. In 1988, it developed The Toronto Alexithymia Scale (TAS-20), consists of 20 items and three factors: a) difficulty of identifying feelings and differences between feelings and bodily sensations; b) difficulty of describing feelings; and c) externally oriented thinking. It's considered that people with eating disorders have specific deficits in identify and communicate their feelings.The present study has as purpose to the instrument validation.It was a cross-sectional study and psychometric character design of a single sample, formed of 435 persons suffering eat…

AdultMaleAdolescentPsychometricsmedia_common.quotation_subjectSample (material)PopulationEmotionsSensationOcean EngineeringComorbiditySeverity of Illness IndexFeeding and Eating DisordersToronto Alexithymia ScaleDiagnostic Self EvaluationYoung AdultAlexithymiamedicinePrevalenceHumansAffective SymptomseducationChildMexicomedia_commonAgededucation.field_of_studyPrincipal Component Analysismedicine.diagnostic_testbusiness.industryCommunication BarriersReproducibility of ResultsMiddle Agedmedicine.diseaseTest (assessment)Eating disordersCross-Sectional StudiesFeelingScale (social sciences)FemalebusinessClinical psychologyCirugia y cirujanos
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Digital assessment of MRI for lumbar disc desiccation. A comparison of digital versus subjective assessments and digital intensity profiles versus di…

1994

During magnetic resonance imaging, a vast amount of digital data on anatomic structures is translated into images, which are then assessed subjectively. The development of an objective, sensitive method to directly assess the digital data would have clear benefits, particularly for clinical research on disc degeneration. The study goals were to develop a method of digital assessment of disc desiccation and to compare digital signal intensity profiles with discographic patterns and macroanatomic findings. Proton density-weighted MRIs were obtained from 45 males (9-77 years) and digital analysis was done with a freely selectable region of interest facility. The adjacent cerebrospinal fluid (C…

AdultMaleAdolescentRadiographyDigital dataDiscographyBody WaterRegion of interestImage Processing Computer-AssistedMedicineHumansOrthopedics and Sports MedicineDigital signalChildIntervertebral DiscAgedLumbar Vertebraemedicine.diagnostic_testbusiness.industryMagnetic resonance imagingAnatomyMiddle AgedMagnetic Resonance ImagingRadiographyIntervertebral diskNeurology (clinical)businessNuclear medicineCadaveric spasm
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Cerebral blood flow velocities after subarachnoid haemorrhage in relation to the amount of blood clots in the initial computed tomography.

1998

In 72 patients with acute subarachnoid haemorrhage (SAH) the relationship between the amount of subarachnoid blood clots detected by initial cranial computed tomography (CCT) up to 48 hours after bleeding and the later development of vasospasm, established by blood flow velocity measurement with transcranial Doppler ultrasound (TCD) was investigated. The serial Doppler examinations started within the first 72 hours after SAH and were carried out every second day up to three weeks. Each Doppler recording was accompanied by a neurological examination. Patients classified as Hunt and Hess grade V were excluded from the study. All patients with remarkable brain oedema in CCT or with intracrania…

AdultMaleAdolescentUltrasonography Doppler TranscranialHemodynamicsmedicineHumanscardiovascular diseasesIntracranial pressureAgedVascular diseasebusiness.industryVasospasmBlood flowLaser Doppler velocimetryIntracranial Embolism and ThrombosisMiddle AgedSubarachnoid Hemorrhagemedicine.diseasenervous system diseasesTranscranial DopplerCerebral blood flowIschemic Attack TransientAnesthesiaCerebrovascular Circulationcardiovascular systemSurgeryFemaleNeurology (clinical)Nuclear medicinebusinessTomography X-Ray ComputedBlood Flow Velocitycirculatory and respiratory physiologyActa neurochirurgica
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A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus

2014

Contains fulltext : 137763.pdf (Publisher’s version ) (Open Access) Recent genome-wide association studies (GWAS) of Hodgkin lymphoma (HL) have identified associations with genetic variation at both HLA and non-HLA loci; however, much of heritable HL susceptibility remains unexplained. Here we perform a meta-analysis of three HL GWAS totaling 1,816 cases and 7,877 controls followed by replication in an independent set of 1,281 cases and 3,218 controls to find novel risk loci. We identify a novel variant at 19p13.3 associated with HL (rs1860661; odds ratio (OR)=0.81, 95% confidence interval (95% CI)=0.76-0.86, Pcombined=3.5 x 10(-10)), located in intron 2 of TCF3 (also known as E2A), a regul…

AdultMaleAdolescent[SDV]Life Sciences [q-bio]TRANSCRIPTION FACTOR E2AGENETIC-ASSOCIATIONGeneral Physics and AstronomyLocus (genetics)Genome-wide association studyHuman leukocyte antigenBiologyGeneral Biochemistry Genetics and Molecular BiologyArticleDISEASEYoung AdultBasic Helix-Loop-Helix Transcription FactorsHumansTOOLGenetic Predisposition to DiseaseAlleleGENOME-WIDE ASSOCIATIONEPSTEIN-BARR-VIRUSGenetic associationAgedGeneticsAged 80 and overRISKMultidisciplinaryCELL-TYPECase-control studyGenetic VariationGeneral ChemistryOdds ratioGenomicsMiddle AgedALLELESHodgkin DiseaseCANCERMalaltia de HodgkinHodgkin lymphoma (HL)GenòmicaGenetic epidemiologyCase-Control StudiesUrological cancers Radboud Institute for Health Sciences [Radboudumc 15]Hodgkin's diseaseChromosomes Human Pair 19Genome-Wide Association Study
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Bone marrow after autologous blood stem cell transplantation and total body irradiation: magnetic resonance and chemical shift imaging.

1993

Magnetic resonance studies of the lumbar, pelvic, and femoral bone marrow were performed in 10 patients after autologous blood stem cell transplantation, including total body irradiation and myeloablative chemotherapy. The posttreatment interval varied between 2 and 6 yr. The appearance on T1-weighted images and the quantitative data obtained from chemical shift imaging (relative fat signal) were compared to 10 age-matched healthy volunteers. The classification of the T1-weighted images yielded no significant differences between the two groups. Chemical shift imaging by determination of the relative fat signal was able to detect a significant fatty replacement of the patients' lumbar (p < .…

AdultMaleAdolescentmedicine.medical_treatmentBiomedical EngineeringBiophysicsBlood cellLumbarBone MarrowmedicineHumansRadiology Nuclear Medicine and imagingFemurChildPelvic BonesChemotherapyLeukemiaLumbar Vertebraemedicine.diagnostic_testChemistrybusiness.industryHematopoietic Stem Cell TransplantationMagnetic resonance imagingTotal body irradiationMiddle AgedCombined Modality TherapyMagnetic Resonance ImagingTransplantationmedicine.anatomical_structureAcute DiseaseFemaleBone marrowStem cellNuclear medicinebusinessWhole-Body IrradiationMagnetic resonance imaging
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Impaired plasma nitric oxide availability and extracellular superoxide dismutase activity in healthy humans with advancing age

2006

This study is aimed to verify the modifications of extracellular superoxide dismutase (EC-SOD) activity and its potential involvement on the mechanism responsible for the impairment of plasma nitric oxide (NO) availability occurring with advancing age in healthy humans. For this purpose, plasma samples were drawn from 40 healthy men, aged 20-92 years, in fasting state and used for measurements of stable end-product nitrite/nitrate (NOx), as expression of NO availability, EC-SOD activity, thiobarbituric acid reactive substances (TBARS) as marker of lipid peroxidation, Trolox equivalent antioxidant capacity (TEAC) as a measure of plasma total antioxidant capacity, and in vitro susceptibility …

AdultMaleAgingmedicine.medical_specialtyAntioxidantThiobarbituric acidextracellular superoxide dismutasemedicine.medical_treatmentTrolox equivalent antioxidant capacitymedicine.disease_causeAntioxidantsGeneral Biochemistry Genetics and Molecular BiologyNitric oxideLipid peroxidationchemistry.chemical_compoundNitric oxide Extracellular superoxide dismutase ; Oxidative stress; Advancing ageadvancing agenitric oxideInternal medicinemedicineTBARSAnimalsHumansoxidative stressGeneral Pharmacology Toxicology and PharmaceuticsAgedAged 80 and overSuperoxide DismutaseFastingGeneral MedicineMiddle AgedLipidsEndocrinologychemistryBiochemistryLow-density lipoproteinLipid PeroxidationExtracellular SpaceOxidative stressLife Sciences
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Lipid Peroxidation, Nitric Oxide Metabolites, and Their Ratio in a Group of Subjects with Metabolic Syndrome

2014

Our aim was to evaluate lipid peroxidation, expressed as thiobarbituric acid-reactive substances (TBARS), nitric oxide metabolites (nitrite + nitrate) expressed asNOx, and TBARS/NOxratio in a group of subjects with metabolic syndrome (MS). In this regard we enrolled 106 subjects with MS defined according to the IDF criteria, subsequently subdivided into diabetic (DMS) and nondiabetic (NDMS) and also into subjects with a low triglycerides/HDL-cholesterol (TG/HDL-C) index or with a high TG/HDL-C index. In the entire group and in the four subgroups of MS subjects we found an increase in TBARS andNOxlevels and a decrease in TBARS/NOxratio in comparison with normal controls. Regarding all these …

AdultMaleAgingmedicine.medical_specialtySettore MED/09 - Medicina InternaArticle SubjectInflammationNitric OxideThiobarbituric Acid Reactive SubstancesBiochemistryNitric oxideLipid peroxidationchemistry.chemical_compoundInsulin resistanceInternal medicinemedicineTBARSHumanslcsh:QH573-671NitriteNitritesTriglyceridesNOxMetabolic SyndromeNitrateslcsh:CytologyCell BiologyGeneral MedicineMiddle Agedmedicine.diseaseEndocrinologyBiochemistrychemistryLipid Peroxidation Nitric Oxide Metabolites Metabolic SyndromeFemaleLipid Peroxidationmedicine.symptomMetabolic syndromeLipoproteins HDLResearch ArticleOxidative Medicine and Cellular Longevity
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Synchronization to metrical levels in music depends on low-frequency spectral components and tempo

2016

Previous studies have found relationships between music-induced movement and musical characteristics on more general levels, such as tempo or pulse clarity. This study focused on synchronization abilities to music of finely-varying tempi and varying degrees of low frequency spectral change/flux. Excerpts from six classic Motown/R&B songs at three different tempos (105, 115, and 130 BPM) were used as stimuli in this experiment. Each was then time-stretched by a factor of 5% with regards to the original tempo, yielding a total of 12 stimuli that were presented to 30 participants. Participants were asked to move along with the stimuli while being recorded with an optical motion capture system.…

AdultMaleAuditory perceptionSpectral fluxBar (music)Speech recognitionmusiikkiExperimental and Cognitive PsychologyMotor Activity050105 experimental psychologySynchronizationliikkeetYoung Adult03 medical and health sciences0302 clinical medicineArts and Humanities (miscellaneous)low-frequency spectral componentsDevelopmental and Educational PsychologyHumans0501 psychology and cognitive sciencesCommunicationMovement (music)business.industry05 social sciencesGeneral Medicinemetrical levels in musicTime perceptionPulse (music)temporytmioppiTime PerceptionAuditory PerceptionFemalesynkronointiPsychologybusinesssynchronizationBeat (music)Music030217 neurology & neurosurgeryPsychological Research
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The long-term effects of rally driving on spinal pathology

2000

Abstract Objectives. To investigate the consequences of rally driving on lumbar degenerative changes. Background. Vehicular driving is suspected to accelerate disc degeneration through whole-body vibration, leading to back problems. However, in an earlier well-controlled study of lumbar MRI findings in monozygotic twins, significant effects of lifetime driving on disc degeneration were not demonstrated. Another study of machine operators found only long-term exposure to vibration on unsprung seats led to a reduction in disc height. Design. Case-control study comparing rally drivers with population sample. Methods. Eighteen top rally drivers and co-drivers, mean age 43 yrs (SD, 10), voluntee…

AdultMaleAutomobile Drivingmedicine.medical_specialtyBiophysicsPoison controlVibrationTimeSpinal OsteophytosisLumbarPhysical medicine and rehabilitationInjury preventionmedicineBack painHumansWhole body vibrationOrthopedics and Sports MedicineIntervertebral DiscLumbar Vertebraemedicine.diagnostic_testbusiness.industryIncidence (epidemiology)Lumbosacral RegionMagnetic resonance imagingMagnetic Resonance ImagingSurgeryOccupational DiseasesBack PainCase-Control StudiesEpidemiological MonitoringDisc degenerationmedicine.symptombusinessIntervertebral Disc DisplacementEnvironmental MonitoringClinical Biomechanics
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