Search results for "barrier"

The ins and outs of cholesterol in the vertebrate retina

2010

Thematic Review Series: Lipids and Lipid Metabolism in the Eye; International audience; The vertebrate retina has multiple demands for utilization of cholesterol and must meet those demands either by synthesizing its own supply of cholesterol or by importing cholesterol from extraretinal sources, or both. Unlike the blood-brain barrier, the blood-retina barrier allows uptake of cholesterol from the circulation via a lipoprotein-based/receptor-mediated mechanism. Under normal conditions, cholesterol homeostasis is tightly regulated; also, cholesterol exists in the neural retina overwhelmingly in unesterified form, and sterol intermediates are present in minimal to negligible quantities. Howe…

Quantum walk on the line through potential barriers

2015

Quantum walks are well-known for their ballistic dispersion, traveling $\Theta(t)$ away in $t$ steps, which is quadratically faster than a classical random walk's diffusive spreading. In physical implementations of the walk, however, the particle may need to tunnel through a potential barrier to hop, and a naive calculation suggests this could eliminate the ballistic transport. We show by explicit calculation, however, that such a loss does not occur. Rather, the $\Theta(t)$ dispersion is retained, with only the coefficient changing, which additionally gives a way to detect and quantify the hopping errors in experiments.

ChemInform Abstract: The Ins and Outs of Proton Complexation

2009

Proton complexation differs from simple protonation by the fact that the coordinated hydrogen atom is bound intramolecularly to more than one donor atom. This is usually achieved by covalent bonding supplemented by hydrogen bonding. In a few cases, however, the complexed proton is hydrogen-bound to all donor atoms, which gives rise to single well (SWHB) and low barrier (LBHB) hydrogen bonds. This tutorial review highlights a full range of proton complexes formed with chelating and “proton-sponge”-type ligands, cryptand-like macropolycycles, and molecules of topological relevance, such as rotaxanes and catenanes. The concept of proton complexation can explain how the smallest cation possible…

Quenching of bandgaps by flow noise.

2009

We report an experimental study of acoustic effects produced by wind impinging on noise barriers based on two‐dimensional sonic crystals with square symmetry. We found that the attenuation strength of sonic‐crystal‐bandgaps decreases for increasing values of low speed. A quenching of the acoustic bandgap appears at a certain speed value that depends of the barrier filling ratio. For increasing values of low speed, the data indicate that the barrier becomes in a sound source because of its interaction with the wind. We conclude that flow noise has paramount importance in designing acoustic barriers based on sonic crystals. [Work supported by Spanish AECI.]

EPR, ENDOR and TRIPLE resonance of amino-substituted 9,10-anthraquinone radicals and the rotation of the amino groups in the solution phase

1996

EPR, ENDOR and TRIPLE resonance spectra were recorded for 1-amino-9,10-anthraquinone (1-aminoAQ), 2-aminoAQ, 1,2-diaminoAQ, 1.4-diaminoAQ, 1,5-diaminoAQ and 2,6-diaminoAQ anion radicals in the solution phase. The rotation of the amino groups is discussed with reference to the experimental data. Rotation barrier calculations were carried out using B3PW91/3-21G* density functional method. The amino groups at positions 1, 4, 5, 8 were found not to be in rotational movement up to the EPR time-scale.

Momentum-resolved photoelectron absorption in surface barrier scattering on Ir(111) and graphene/Ir(111)

2017

Physical review / B 96(15), 155108 (2017). doi:10.1103/PhysRevB.96.155108

Industrial Symbiosis: A Mechanism to Guarantee the Implementation of Circular Economy Practices

2022

There is a growing concern regarding the scarcity of natural resources. The levels of resource exploitation generated by the current system of production and consumption has led the European Commission to develop a set of guidelines that aim to reduce the pressure on natural resources. The set of guidelines proposed by the European Union is based on the transformation of the current linear economic system into a circular system in which resources and materials remain in the production system for longer. However, for this change to take effect, practical measures are required. This paper presents an industrial symbiosis approach as a practical application of a circular economy model. The aim…

Coulomb Effects on Few-Body Scattering States

1986

Modifications of stationary momentum space scattering theory, necessitated by the presence of Coulomb forces, are described, both in the formalism which uses unscreened Coulomb potentials and in the screening and renormalization approach. Thereby, emphasis is laid on exposing the conceptual differences, as well as the different, presently achieved status of applicability. Some of the unresolved problems in both methods are enumerated.

2014

In the pathogenesis of Alzheimer’s disease (AD) the homeostasis of amyloid precursor protein (APP) processing in the brain is impaired. The expression of the competing proteases ADAM10 (a disintegrin and metalloproteinase 10) and BACE-1 (beta site APP cleaving enzyme 1) is shifted in favor of the A-beta generating enzyme BACE-1. Acitretin–a synthetic retinoid–e.g., has been shown to increase ADAM10 gene expression, resulting in a decreased level of A-beta peptides within the brain of AD model mice and thus is of possible value for AD therapy. A striking challenge in evaluating novel therapeutically applicable drugs is the analysis of their potential to overcome the blood-brain barrier (BBB)…

2015

Transporters of the ATP-binding cassette (ABC) family such as MDR1 play a pivotal role in persistence of brain homeostasis by contributing to the strict permeability properties of the blood–brain barrier. This barrier on one hand compromises treatment of central nervous system diseases by restricting access of drugs; on the other hand, an impaired or altered function of barrier building cells has been described in neurological disorders. The latter might contribute to increased vulnerability of the brain under pathological conditions or even enforce pathogenesis. Here, we present a novel approach for a systematic examination of drug impact on Mdr1 gene expression by establishing a dual repo…