Search results for "basi"
showing 10 items of 12854 documents
The effect of nanoparticle size and NLS density on nuclear targeting in cancer and normal cells; impaired nuclear import and aberrant nanoparticle in…
2017
The cell nucleus is an interesting target in many diseases with particular interest in cancer. Previously, nuclear targeted small and large chitosan nanoparticles (S-NPs≈25nm, and L-NPs≈150nm respectively), modified with low, intermediate and high densities of NLS (L-NLS, I-NLS and H-NLS) were developed and assessed in L929 fibroblasts. However, to evade apoptosis and stimulate tumor growth cancer cells are capable of manipulating the nuclear-cytoplasmic transport on many levels, making NPs that are capable of nuclear targeting in normal cells incapable of doing so in cancer. For such reason, here, the nuclear delivery efficiency of S-NPs and L-NPs was assessed as a function of their NLS de…
Nitrated Fatty Acids Modulate the Physical Properties of Model Membranes and the Structure of Transmembrane Proteins
2017
Nitrated fatty acids (NO2 -FAs) act as anti-inflammatory signal mediators, albeit the molecular mechanisms behind NO2 -FAs' influence on diverse metabolic and signaling pathways in inflamed tissues are essentially elusive. Here, we combine fluorescence measurements with surface-specific sum frequency generation vibrational spectroscopy and coarse-grained computer simulations to demonstrate that NO2 -FAs alter lipid organization by accumulation at the membrane-water interface. As the function of membrane proteins strongly depends on both, protein structure as well as membrane properties, we consecutively follow the structural dynamics of an integral membrane protein in presence of NO2 -FAs. …
Nitric oxide metabolism is impaired by type 1 diabetes and diabetic nephropathy
2020
Diabetes leads to reduced nitric oxide bioavailability, resulting in endothelial dysfunction. However, overproduction of nitric oxide due to hyperglycaemia is associated with oxidative stress and tissue damage. The objective of this study was to characterise nitric oxide production (NO) and added nitrite and nitrate (NO(2)(-)+NO(3)(-)) concentration in the blood and urine of patients with and without diabetic nephropathy. A total of 268 patients with type 1 diabetes and 69 healthy subjects were included. Diabetic nephropathy was defined as macroalbuminuria and/or estimated glomerular filtration rate below 60 ml/min/1.73 cm(2). NO(2)(-)+NO(3)(-) concentration was measured by Griess reaction.…
Comparison between a detailed and a simplified integrated model for the assessment of urban drainage environmental impact on an ephemeral river
2008
The benefit of integrated analysis has been demonstrated in technical literature and it is also required by the EU Water Framework Directive 60/2000, which proposes a water-quality-orientated view of the whole urban drainage system and oversees new ways of assessing its performance. Integrated models, such as any complex modelling approach, often have prohibitive data availability requirements that reduce their applicability. Moreover, widely different approaches can be applied, ranging from simple conceptual models to complex physically based ones. In the present paper, two approaches have been compared using data from an experimental catchment in Bologna ( Italy), which consists of a part…
"Dżafar z Bagdadu" Janusza Makarczyka jako cenne źródło wiedzy o historii i literaturze arabskiej epoki Abbasydów
2018
This article deals with Janusz Makarczyk’s bestselling historical romance Jafar of Baghdad, first published in 1950. Makarczyk had a varied career as a journalist, travel writer of the ‘globtrotter school’, military officer, diplomat and academic; his deep involvement with the Middle East and Arab history began in the 1926 when he was sent to the Polish consulate in Jerusalem. The life of Jafar ibn Yahya provided him not only with enough material for a gripping story of love and romance but also a pretext for painting a broad canvas of historical events and personages. Addressed to younger readers, the book is didactic in the sense that it offers them basic information about Islam (e.g. the…
The Administration of Escherichia coli Nissle 1917 Ameliorates Development of DSS-Induced Colitis in Mice
2018
The beneficial effects of probiotics on immune-based pathologies such as inflammatory bowel disease (IBD) have been well reported. However, their exact mechanisms have not been fully elucidated. Few studies have focused on the impact of probiotics on the composition of the colonic microbiota. The aim of the present study was to correlate the intestinal anti-inflammatory activity of the probiotic Escherichia coli Nissle 1917 (EcN) in the dextran sodium sulfate (DSS) model of mouse colitis with the changes induced in colonic microbiota populations. EcN prevented the DSSinduced colonic damage, as evidenced by lower disease activity index (DAI) values and colonic weight/length ratio, when compa…
Ernesto Basile e lo studio della figura umana nel disegno "dal vero" e "al vero".
2012
Questo nuovo corpus di opere supporta l'ipotesi che, al contrario, l'attenzione data al disegno dal vero, non soltanto quello architettonico o floreale, sia stata una costante nell'opera basiliana, e che il ritratto e, soprattutto, più in generale, il disegno di figura, ne siano una parte strutturale. E questa attenzione non si limita al piano ideologico, come si potrebbe dedurre dall'accalorato intervento del 1879 sulla rivista «Pensiero ed Arte», con il quale il giovane architetto rivolgeva pubblicamente le proprie richieste al senatore palermitano Perez, l'allora Ministro della Pubblica Istruzione, in merito all'auspicata realizzazione di una Scuola di Belle Arti a Palermo, affermando: «…
Student intention to engage in leisure-time physical activity: The interplay of task-involving climate, competence need satisfaction and psychobiosoc…
2018
Grounded in achievement goal theory and basic psychological needs theory, the aim of this study was to examine the impact of the interaction of perceived motivational climate in physical education with psychological needs satisfaction (relatedness, competence and autonomy) and psychobiosocial states on student intention to engage in leisure-time physical activity. Participants ( N = 470 Italian students, 287 boys and 183 girls, aged 16–19 years) completed the Teacher-Initiated Motivational Climate in Physical Education Questionnaire, the Psychological Needs Satisfaction Scale in Physical Education, the Psychobiosocial States Questionnaire, and a measure of intention to engage in leisure-tim…
Sakņu piepes Heterobasidion spp. izplatība parastās egles (Picea abies) audzēs uz bijušajām lauksaimniecības zemēm
2019
Heterobasidion spp. izraisītā sakņu trupe nodara ievērojamu kaitējumu skuju koku mežos, kā arī rada nozīmīgus finansiālus zaudējumus mežsaimniecībā. Sakņu piepe galvenokārt inficē egļu audzes caur meža kopšanas laikā atstātiem celmiem, tālāk izplatoties caur sakņu kontaktu vietām. Ņemot vērā to, ka pēdējo dekāžu laikā arvien vairāk tiek apmežotas bijušās lauksaimniecības zemes, ir svarīgi noskaidrot, kā izplatīsies Heterobasidion spp. parastās egles audzēs uz bijušajām lauksaimniecības zemēm, kurās veikta meža kopšana. Darbā tika apsekotas 15 egļu audzes, no kurām astoņās konstatēta Heterobasidion sakņu trupe. Divas no šīm audzēm…
OpenDigi toimintamallin käsikirja : opettajat oppimistaitojen ja digipedagogiikan kehittäjäyhteisöissä
2020
Yhteiskunnallisen muutoksen kiihtyessä on muuttuneisiin osaamistarpeisiin reagoitava myös koulutuksessa. Uudeksi kansalaistaidoksi ja ammatillisen osaamisen ytimeksi on nousemassa kyky uudistua ja sopeutua jat-kuvaan muutokseen. Suomalaisen koulutuksen laatu nojaa vahvasti akateemiseen opettajankoulutukseen. Yh-teiskunnallinen kehitys haastaa opettajankoulutusta ja kouluja tukemaan entistä vahvemmin ihmisten aktiivista roolia muutoksen tekijöinä ja siihen sopeutujina. Tutkintojen suorittamisen lisäksi koulutusjärjestelmän tulee antaa parempia valmiuksia aktiiviseen oppimiseen. Tämä edellyttää uudistumista koulutuksen kaikilla tasoilla. Koulutuksen muutos edellyttää oppilaitoksissa toimivien…