Search results for "basic research"
showing 10 items of 76 documents
Accommodation in human eye models: a comparison between the optical designs of Navarro, Arizona and Liou-Brennan.
2017
Aim To simulate and compare accommodation in accommodative and non-accommodative human eye models. Methods Ray tracing and optical design program was used. Three eye models were designed and studied: the Navarro, the Arizona and the Liou-Brennan. In order to make the Navarro and Liou-Brennan models to accommodate, specific geometric parameters of the models were altered with values that were chosen from the literature. For the Arizona model, its' mathematical functions for accommodation were used for the same accommodative demands. The simulation included four distances of accommodation for each model: at infinity, 3, 1 and 0.5 m.The results were diffraction images of a "letter F" for graph…
Histological evaluation of the effect of low-level laser on distraction osteogenesis in rabbit mandibles
2009
Objectives: This study evaluated the action of low level laser therapy (LLLT) on the percentage of newly formed bone in rabbit mandibles that underwent distraction osteogenesis (DO). Study design: Ten rabbits underwent bone lengthening according to the following protocol: Latency ? 3 days; Activation ? 7 days 0.7 mm/d; and Consolidation ? 10 days. The control group was composed of 4 rabbits. The experimental group, composed of 6 rabbits, received infrared GaAlAs LLLT (?=830 nm, P=40 mW) according to the following protocol: point dose of 10 J/cm2 applied directly on the bone site that underwent DO during bone consolidation at 48-hour intervals. Results: The percentage of newly formed bone wa…
Experimental Study of the Effects of EIPA, Losartan, and BQ-123 on Electrophysiological Changes Induced by Myocardial Stretch
2015
[ES] Introducción y objetivos Se han implicado diversos mecanismos en la respuesta mecánica al estiramiento miocárdico, que incluyen la activación del intercambiador Na+/H+ por acciones autocrinas y paracrinas. Se estudia la participación de estos mecanismos en las respuestas electrofisiológicas al estiramiento agudo miocárdico mediante el análisis de los cambios inducidos con fármacos. Métodos Se analizan las modificaciones de la fibrilación ventricular inducidas por el estiramiento agudo miocárdico en corazones de conejo aislados y perfundidos utilizando electrodos múltiples epicárdicos y técnicas cartográficas. Se estudian 4 series: control (n = 9); durante la perfusión del antagonista d…
Direct Measurement of theWProduction Charge Asymmetry inpp¯Collisions ats=1.96 TeV
2009
We wish to thank R.S. Thorne and W.J. Stirling for useful discussions on the theoretical predictions.We thank the Fermilab staff and the technical staffs of the participating institutions for their vital contributions. This work was supported by the U.S. Department of Energy and National Science Foundation; the Italian Istituto Nazionale di Fisica Nucleare; the Ministry of Education, Culture, Sports, Science and Technology of Japan; the Natural Sciences and Engineering Research Council of Canada; the National Science Council of the Republic of China; the Swiss National Science Foundation; the A.P. Sloan Foundation; the Bundesministerium fur Bildung und Forschung, Germany; the Korean Science…
Instrumental calculation, cognitive role-playing, or both?: self-perceptions of Seconded National Experts in the European Commission
2011
This is the authors’ final, accepted and refereed manuscript to the article Most work studying micro-processes of integration – i.e. how agents develop identities and decision-making behaviours within a particular institution – offers explanations based on either instrumental rationality or socialisation. This article proposes a two-dimensional framework that allows analysing under which conditions both logics of social action co-exist. Our empirical analysis employs a unique dataset from a 2011 survey of all 1098 currently active Seconded National Experts (SNEs) in the European Commission. We find that a) instrumental cost-benefit calculation and cognitive role-playing (as semi-reflexive s…
Dal FIRB al Marie Curie: proposte di Progetti interdisciplinari per il futuro delle Scienze Umane
2016
From the FIRB to the Marie Curie Project: this report presents the inter- and multidisciplinary approach as well the latest scientific results of a Researcher in Greek Language and Literature as Principal Investigator and Proponent of Research Projects at national and european level, in order to seek funding for the survival of the human studies.
Bildungsexpansion, soziale Klasse und die Wahl von Latein als Strategie der Distinktion
2021
In times of educational expansion, privileged families are looking for new strategies of distinction. Referring to Pierre Bourdieu���s theory of distinction, we argue that choosing Latin at school ��� a language that is no longer spoken and therefore has no direct value ��� is one of the strategies of privileged families to set themselves apart from less privileged families. Based on two surveys we conducted at German schools, the paper analyzes the relationship between parents��� educational background and the probability that their child will learn Latin. Results indicate that historically academic families have the strongest tendency towards learning Latin, followed by new academic famil…
RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy
2014
Macroautophagy is a degradative pathway that sequesters and transports cytosolic cargo in autophagosomes to lysosomes, and its deterioration affects intracellular proteostasis. Membrane dynamics accompanying autophagy are mostly elusive and depend on trafficking processes. RAB GTPase activating proteins (RABGAPs) are important factors for the coordination of cellular vesicle transport systems, and several TBC (TRE2-BUB2-CDC16) domain-containing RABGAPs are associated with autophagy. Employing C. elegans and human primary fibroblasts, we show that RAB3GAP1 and RAB3GAP2, which are components of the TBC domain-free RAB3GAP complex, influence protein aggregation and affect autophagy at basal an…
Female Vascular Senescence
2012
Long before the existence of cardiovascular imaging, Sir William Osler axiom that “man is as old as his arteries”. Followed by several physicians for decades, this aphorism has been widely confirmed by studies demonstrating that risk factors for cardiovascular disease increase as we age (Cooper et al., 1994; Lakatta & Levy, 2003). Nevertheless, a flaw in this statement is the generalization that men and women age similarly. Much data from clinical and basic research have established that vascular aging in women does not follow the same chronology as in men (Shaw et al., 2006; Pereira et al., 2010; Takenouchi et al., 2009). If known risk factors that influence cardiovascular aging are exclud…
Collimation and asymmetry of the hot blast wave from the recurrent nova V745 Scorpii
2016
The recurrent symbiotic nova V745 Sco exploded on 2014 February 6 and was observed on February 22 and 23 by the Chandra X-ray Observatory Transmission Grating Spectrometers. By that time the supersoft source phase had already ended and Chandra spectra are consistent with emission from a hot, shock-heated circumstellar medium with temperatures exceeding 10^7K. X-ray line profiles are more sharply peaked than expected for a spherically-symmetric blast wave, with a full width at zero intensity of approximately 2400 km/s, a full width at half maximum of 1200 +/- 30 km/s and an average net blueshift of 165 +/- 10 km/s. The red wings of lines are increasingly absorbed toward longer wavelengths by…